Method for building non-human primate model with compulsive ritualistic behaviors

A primate and behavioral technology, applied in the field of zoology, can solve the problems of animals lacking language expression ability and difficulty in establishing primate animal models

Active Publication Date: 2020-02-21
CENT FOR EXCELLENCE IN BRAIN SCI & INTELLIGENCE TECH CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The nervous system of non-human primates (such as rhesus monkeys, etc.) is relatively close to that of humans in structure and function, but in view of the living habits and other reasons, the lack of language expression ability of a

Method used

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  • Method for building non-human primate model with compulsive ritualistic behaviors
  • Method for building non-human primate model with compulsive ritualistic behaviors
  • Method for building non-human primate model with compulsive ritualistic behaviors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Embodiment 1. Feasibility observation of stereotyped behavior induced by group or individual behavior

[0070] In this example, the monkeys were bred periodically to induce stereotyped behavior. The "staged" refers to the feeding time is greater than or equal to 4 weeks. The number of experimental monkeys was 100. Install surveillance video equipment and set up surveillance.

[0071] Set up multiple breeding cages, and carry out "single / cage" and "multiple (2-4) / cage" feeding of healthy experimental monkeys. Among them, when the feeding method of "single bird / cage", the cage is 800 × 800 × 800 (length × width × height) mm; when the feeding method of "2 animals / cage", the cage is 1600 × 800 × 800 (length × Width × height) mm; when the feeding method of "3 birds / cage", the cage is 2400×800×800 (length×width×height) mm; when the feeding method of "4 animals / cage", the cage is 1600×1600× 800 (length x width x height) mm.

[0072] Put monkeys weighing 4-7kg into the cag...

Embodiment 2

[0075] Embodiment 2, the selection of breeding cage

[0076] In this example, monkeys were bred periodically to induce stereotyped behavior. The "staged" refers to the feeding time is greater than or equal to 4 weeks. The number of experimental monkeys was 100. Install surveillance video equipment and set up surveillance.

[0077] Healthy experimental monkeys were reared in a single cage, and various cages were set up with different sizes, as shown in Table 2, to observe the best cages for inducing stereotyped behaviors or ritual-like actions. Multiple breeding cages can be placed in the same or different rooms, and about 10 cages are placed in each room in this experiment.

[0078] Table 1. Design of breeding cages

[0079]

[0080] Put monkeys weighing 4-7kg into the cages designed in Table 1, and put only one monkey in each cage, and observe the monkeys' stereotyped behavior or ritual-like movements.

[0081] Observation time: Analyze daily 8:00-8:10, 9:00-9:10, 10:...

Embodiment 3

[0084] Embodiment 3, the selection of observation time

[0085] Raise healthy experimental monkeys in a single cage, set up multiple breeding cages, and observe the behavioral habits of the monkeys to determine the best time to observe stereotyped behaviors. Multiple breeding cages can be placed in the same or different rooms, and about 10 cages are placed in each room in this experiment.

[0086]The size of the breeding cage is 800×800×800 mm. Put monkeys with a weight of 4-7kg into the cages designed in Table 1, and put only one monkey in each cage, and observe the behavioral habits of the monkeys.

[0087] Analysis of the first time and last time of daily stereotyped behavior: analysis of 14 consecutive days, the time when each experimental monkey first appeared stereotyped behavior and the time when the last time stereotyped behavior occurred in a single day. Each experimental monkey has three meals a day, and whether there are stereotyped behaviors or ritual-like action...

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Abstract

The invention provides a method for building a non-human primate model with compulsive ritualistic behaviors. Aiming to overcome the technical defect that currently no typical ritualistic behavior animal model exists in the field, the invention discloses a method for inducing the ritualistic behaviors of an animal, and the animal model which has typical ritualistic behaviors and is evident in behavioral performance can be obtained in a short time by the method.

Description

technical field [0001] The invention belongs to the field of zoology, and more particularly, the invention relates to a method for inducing ritual-like behaviors in non-human primates. Background technique [0002] Due to the obvious species differences between rodents and primates, especially when it involves high-level brain functions such as emotion, whether the experimental conclusions obtained in the mouse model are also applicable to primates still needs to be further elucidated. [0003] The nervous system of non-human primates (such as rhesus monkeys, etc.) is relatively close to that of humans in structure and function, but in view of the living habits and other reasons, the lack of language expression ability of animals, etc., it is currently difficult to establish the nervous system of primates. An animal model of ritual-like behavior in animals. [0004] So far, there is no recognized ritual-like behavior model for non-human primates at home and abroad. Conten...

Claims

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Application Information

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IPC IPC(8): A01K67/02
CPCA01K67/02
Inventor 熊志奇孙强翟荣伟王振
Owner CENT FOR EXCELLENCE IN BRAIN SCI & INTELLIGENCE TECH CHINESE ACAD OF SCI
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