Hyaluronic acid gel composition for negative-pressure multi-needle injection and preparation method therefor

A gel composition and a technology of hyaluronic acid, which are applied in the field of biomedicine, can solve the problems of short maintenance time of hyaluronic acid, unsuitable for water-light injection, accelerated onset time, etc. The effect of light injection, avoiding toxic side effects

Active Publication Date: 2020-02-21
BIOREGEN BIOMEDICAL (CHANGZHOU) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the technical problem that the cross-linked hyaluronic acid gel in the prior art has a long degradation time, it is not suitable for water-light injection, and its effect is slow; the hyaluronic acid used for water-light injection maintains a short time in the body. The water-retaining time of hyaluronic acid injected by water-light needle injection and the onset time are accelerated. This application provides a hyaluronic acid gel composition for water-light injection, which has a longer degradation and absorption time and is more effective than existing hyaluronic acid. Long hydrating and moisturizing maintenance time and faster onset time, suitable for water light injection, impurities are less toxic, and will not produce bulging, so water light injection can be used to improve skin quality more effectively

Method used

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  • Hyaluronic acid gel composition for negative-pressure multi-needle injection and preparation method therefor
  • Hyaluronic acid gel composition for negative-pressure multi-needle injection and preparation method therefor
  • Hyaluronic acid gel composition for negative-pressure multi-needle injection and preparation method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1: Preparation of disulfide bond cross-linked hyaluronic acid gel

[0048] Hyaluronic acid thiolated derivatives are prepared using sodium hyaluronate with a molecular weight of 180KDa as a raw material, prepared by the method reported by Shu et al. / g and 57μmol / g.

[0049] Dissolve the above-mentioned hyaluronic acid mercapto derivatives to obtain an aqueous solution with a content of 6 mg / mL or 12 mg / mL, adjust the pH value of the solution to 7.4, transfer it into a sterile glass container after sterilizing and filtering; keep it airtight at room temperature for 4 weeks, the solution Loss of fluidity and formation of disulfide cross-linked hydrogels.

Embodiment 2

[0050] Embodiment 2: the preparation of hyaluronic acid gel composition

[0051] Sodium hyaluronate (50KDa) was dissolved to obtain an aqueous solution with a content of 12 mg / mL, the pH value of the solution was adjusted to 7.4, and it was sterilized and filtered for use.

[0052] The disulfide cross-linked hyaluronic acid gel (12mg / mL) prepared in Example 1 and the above-mentioned hyaluronic acid aqueous solution were mixed according to the volume ratio of 1:11, 1:5, 1:3, 1:2, 1:1.4, 1:0.5, 1:0.3, 1:0.2 and 1:0.091 were physically stirred and mixed to obtain the hyaluronic acid gel composition with the ratio shown in the table below.

[0053]

Embodiment 3

[0054] Example 3: Injectable Performance Evaluation of Hyaluronic Acid Gel Composition

[0055] Using Derma (Demasa) 2nd generation water-light injection device, to test the injectability of the hyaluronic acid gel composition prepared in Example 2 through conventional water-light injection needles (nine needles). When the content of disulfide cross-linked hyaluronic acid in the hyaluronic acid gel composition is 1 mg / mL, 2 mg / mL, 3 mg / mL and 4 mg / mL, it has good injectability; and when the content ≥ 5 mg / mL When it is less than mL, it is difficult to inject through the water-light injector.

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Abstract

The invention discloses a hyaluronic acid gel composition for negative-pressure multi-needle injection. The hyaluronic acid gel composition contains 1) disulfide bond cross-linked hyaluronic acid, wherein the content of the hyaluronic acid in gel is not higher than 10mg / mL; and 2) non-crosslinked hyaluronic acid. When the hyaluronic acid gel composition disclosed by the invention is applied to negative-pressure multi-needle injection, the hyaluronic acid gel composition has unique advantages, injection by ultrafine needle heads of negative-pressure multi-needle injection needles is facilitated, good uniform distribution in a subcutaneous shallow surface layer can be achieved, and a bulging phenomenon does not occur; and the effect taking speed is high, water replenishing and moisture preserving effects are long in hold time, and the skin texture of skin can be effectively improved.

Description

technical field [0001] The present invention relates to the field of biomedicine, in particular to a hyaluronic acid gel composition for hydro-optic injection, and a preparation method of the hyaluronic acid gel composition for hydro-optic injection. Background technique [0002] In recent years, the medical beauty industry at home and abroad has developed rapidly, and various emerging beauty technologies have been developed. Water light injection is one of the most extensive medical cosmetology projects at home and abroad. It can effectively solve the problem that skin care products used on the body surface are not easily absorbed through the epidermal barrier. senescence. Water-light injection originated from Mesotherapy proposed by French doctor Michal Pistor in 1952. Its concept is to inject a small amount of therapeutic substances in the local superficial surface; after decades of hard work, the current water-light injection technology was developed. Shuiguang injecti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/04A61Q19/00C08J3/075C08L5/08
CPCA61K8/042A61K8/735A61K2800/91A61Q19/00C08J3/075C08J2305/08C08J2405/08
Inventor 王云云胡慕兰张红晨王坤王昕宇宋文俊舒晓正
Owner BIOREGEN BIOMEDICAL (CHANGZHOU) CO LTD
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