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Traditional Chinese medicine composition containing 7-oh-mitragynine

一种帽柱木碱、组合物的技术，应用在医药领域，能够解决理疗效果差、安全隐患、不易佩戴等问题，达到高提取率和纯度、抗疲劳肌肉疼痛、缓解肌肉疼痛的效果

Active Publication Date: 2021-05-04
JIANGHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above products often have disadvantages such as poor physical therapy effect or difficult to wear, and sometimes even have potential safety hazards

Method used

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  • Traditional Chinese medicine composition containing 7-oh-mitragynine
  • Traditional Chinese medicine composition containing 7-oh-mitragynine
  • Traditional Chinese medicine composition containing 7-oh-mitragynine

Examples

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Effect test

Embodiment 1

[0040] This embodiment provides a method for extracting 7-OH-mitragynine, a traditional Chinese medicine composition comprising 7-OH-mitragynine, and a health care belt comprising a traditional Chinese medicine composition; wherein,

[0041] The extraction method of 7-OH-mitragynine comprises the following steps:

[0042](a) crush the dried kratom leaves, add chloroform according to the solid-liquid ratio of 1:10, adjust the pH value to 6.11 with a 10% acetic acid solution by mass fraction, perform ultrasonic extraction for 45 min at room temperature, and centrifuge to take the supernatant, This process was repeated 3 times, and the 3 supernatants were concentrated under reduced pressure to obtain the first concentrated solution; wherein, the ultrasonic power was 200W;

[0043] (b) Add an equal volume of petroleum ether to the first concentrated solution, extract at 50° C., take the lower layer liquid after standing, repeat this process 3 times, combine the lower layer liquid ...

Embodiment 2

[0051] This embodiment provides a method for extracting 7-OH-mitragynine, a traditional Chinese medicine composition comprising 7-OH-mitragynine, and a health care belt comprising a traditional Chinese medicine composition; wherein,

[0052] The extraction method of 7-OH-mitragynine comprises the following steps:

[0053] (a) Grind the dried kratom leaves, add chloroform according to the solid-liquid ratio of 1:12, adjust the pH value to 6.11 with 10% acetic acid solution by mass fraction, ultrasonically extract for 1.5 h at room temperature, and centrifuge to take the supernatant , this process was repeated 3 times, and the supernatant was concentrated under reduced pressure for 3 times to obtain the first concentrated solution; wherein, the ultrasonic power was 200W;

[0054] (b) Add an equal volume of petroleum ether to the first concentrated solution, extract at 40°C, and take the lower layer liquid after standing. This process is repeated 3 times, and the lower layer liqu...

Embodiment 3

[0060] This embodiment provides a method for extracting 7-OH-mitragynine, a traditional Chinese medicine composition comprising 7-OH-mitragynine, and a health care belt comprising a traditional Chinese medicine composition; wherein,

[0061] The extraction method of 7-OH-mitragynine comprises the following steps:

[0062] (a) crush the dried kratom leaves, add chloroform according to the solid-liquid ratio of 1:15, adjust the pH value to 6.28 with 10% acetic acid solution with a mass fraction, ultrasonically extract for 30 min at room temperature, and centrifuge to take the supernatant, This process was repeated 3 times, and the 3 supernatants were concentrated under reduced pressure to obtain the first concentrated solution; wherein, the ultrasonic power was 400W;

[0063] (b) Add an equal volume of petroleum ether to the first concentrated solution, extract at 45°C, and take the lower layer liquid after standing. This process is repeated 3 times, and the lower layer liquid i...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition containing 7‑OH‑mitragynine. The traditional Chinese medicine composition containing 7‑OH‑mitragynine is made of the following raw materials in parts by weight: 7‑OH‑mitragynine 5 ~30 parts, Sanye Wujia 10~40 parts, guarana extract 5~35 parts, mint 5~40 parts. The traditional Chinese medicine composition containing 7-OH-mitragynine in the present invention has the compound effects of refreshing the mind, anti-fatigue and relieving muscle pain.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a traditional Chinese medicine composition containing 7-OH-mitragynine. Background technique [0002] Kratom is a medicinal plant of the genus Kratom that grows in Southeast Asian countries such as Thailand and Malaysia. It is also found in Yunnan at an altitude of 1,000 meters in my country. The leaves have been used as far back as the late 1800's to treat muscle pain, diarrhea, coughs, and to reduce the intake of costly opioids and to treat the withdrawal effects of opiate addiction. In addition, Malaysians and Thais also consume this plant to enhance their endurance for hard work under the hot sun. The main active ingredient of Kratom is indole alkaloids, of which mitragynine accounts for more than 66% of the total alkaloids, and 7-OH-mitragynine is a new alkaloid isolated in recent decades. Studies have found that it has stronger lipophilicity than mitragynine, easily pene...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D459/00A61K31/475A61K36/254A61K36/77A61K36/534A61P25/26A61P21/00A61P29/00A61P39/00A61F7/02A61M35/00
CPCC07D459/00
Inventor 徐丛玥乐凯
Owner JIANGHAN UNIVERSITY
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