Application of Malus toringoides and/or Malus toringoides extract in preparation of drugs for preventing and treating nonalcoholic liver diseases and/or nonalcoholic liver injury

A non-alcoholic, Russian-colored tea technology, applied in the field of non-alcoholic liver disease treatment, can solve problems such as clinical treatment drugs without NAFLD, achieve inhibition of fat accumulation in liver cells, significant preventive effect, and high safety. Effect

Inactive Publication Date: 2020-02-28
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no specific clinical treatment for NAFLD, which makes NAFLD a great challenge in the field of contemporary medicine.

Method used

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  • Application of Malus toringoides and/or Malus toringoides extract in preparation of drugs for preventing and treating nonalcoholic liver diseases and/or nonalcoholic liver injury
  • Application of Malus toringoides and/or Malus toringoides extract in preparation of drugs for preventing and treating nonalcoholic liver diseases and/or nonalcoholic liver injury
  • Application of Malus toringoides and/or Malus toringoides extract in preparation of drugs for preventing and treating nonalcoholic liver diseases and/or nonalcoholic liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation method of embodiment 1 Russian tea extract

[0030] 1. Preparation of Russian tea alcohol extract: the alcohol extract is extracted with 80% ethanol solution by ultrasound (operating voltage: 220V / 50KHZ v; power: 35Kw), the extraction temperature is 25°C, and the ratio of solid to liquid is 1:10 The extraction time was 30 min, and the filter residue was extracted three times, then centrifuged at 4000 r / min for 10 min, and the supernatant was collected and combined, and then freeze-dried.

[0031] 2. Preparation of the water extract of Russian tea: the water extract mainly simulates the characteristics of torment in the Pharmacopoeia, boiled in boiling water for 1 hour, and the ratio of solid to liquid is 1:15. After boiling, centrifuge while hot at 4000r / min, centrifuge for 10min, filter the supernatant with suction, and finally freeze-dry (-55°C; vacuum degree 200; 48h) for use.

Embodiment 2

[0033] The method of feeding high-fat feed was used to establish the model of NAFLD, and the prevention and treatment effect of the ethanol and water extracts of Russian tea on NAFLD was observed through animal model experiments.

[0034] 1. Experimental materials

[0035] 1.1 Animals, feed and reagents

[0036] SD male rats were purchased from Liaoning Changsheng Biotechnology Co., Ltd. High-fat feed, Jinduofeng Biological Co., Ltd. Kits, Nanjing Jiancheng Biotechnology Co., Ltd., Biyuntian Biotechnology Co., Ltd.

[0037] 1.2 Instruments

[0038] Fully automatic biochemical analyzer, Shenzhen Redu Life Science Co., Ltd.

[0039] 2. Methods and Results

[0040] 2.1 Modeling

[0041] The male rats are SPF grade SD rats aged 4-8 weeks, with a body weight of about 200 g and a deviation of about 5% of body weight. The experimental animals were from Hunan Slack Jingda Experimental Animal Co., Ltd., and the number of the rats was SCXK (Xiang) 2016-0002. Specifically, 48 rat...

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Abstract

The invention provides application of Malus toringoides and / or Malus toringoides extract in the preparation of drugs for preventing and treating nonalcoholic liver diseases and / or nonalcoholic liver injury. The Malus toringoides and / or Malus toringoides extract have an evident preventing and treating effect on the nonalcoholic liver diseases. Application results show that the Malus toringoides extract can effectively inhibit hepatic index increasing so as to inhibit non-alcoholic fatty liver; the Malus toringoides can effectively inhibit fat accumulation, caused by long-term high-fat diet, inliver cells. The Malus toringoides and the Malus toringoides extract used for preparing the drugs for preventing and treating the nonalcoholic liver diseases have the advantages that the Malus toringoides is a wide-ranging species in China and cheap; the Malus toringoides is an edible natural plant material, so that the Malus toringoides is high in safety; the extraction and preparation process ofthe Malus toringoides is convenient and simple.

Description

technical field [0001] The invention relates to the technical field of non-alcoholic liver disease treatment, in particular to the application of russian tea and / or russian tea extract in the preparation of medicines for preventing and treating non-alcoholic liver disease and / or non-alcoholic liver injury. Background technique [0002] Non-alcoholic fatty liver disease (NAFLD) refers to a clinicopathological syndrome characterized by excessive fat deposition in liver cells caused by alcohol and other definite liver damage factors, which is related to insulin resistance and Genetic predisposition closely associated with acquired metabolic stress-induced liver injury. Including simple fatty liver (SFL), nonalcoholic steatohepatitis (NASH) and related cirrhosis. With the global epidemic trend of obesity and its related metabolic syndrome. [0003] NAFLD can not only directly lead to compensated liver cirrhosis, liver cancer and other diseases, but also affect the progress of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61P1/16A23F3/34A23L33/105
CPCA23F3/34A23L33/105A23V2002/00A61K36/73A61P1/16A23V2200/30A23V2250/21
Inventor 程桂广樊志峰曹建新杨美莲赵天瑞蔡圣宝
Owner KUNMING UNIV OF SCI & TECH
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