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Multifunctional transdermal absorption promoter, and preparation method and application thereof

An absorption enhancer and multifunctional technology, applied in the field of multifunctional transdermal absorption enhancer and its preparation and application, can solve the problems of unfavorable promotion and application of transdermal enhancer, existence of toxic and harmful components, toxicity of body organs, etc. , to achieve the effect of promoting transdermal absorption, low cost, and promoting absorption

Pending Publication Date: 2020-03-06
杜立波
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned commonly used transdermal absorption enhancers all have their own shortcomings, such as irritation to the skin if used for a long time, toxicity to body organs when used throughout the body, difficulty in production, and high cost
In addition, the following problems still exist in the existing transdermal enhancers: the transdermal efficiency is very low, and the amount of effective substances absorbed through the pores does not exceed 10%; there are toxic and harmful components, which are highly toxic; the structure is unstable and the moisture retention is poor
The existence of the above problems is unfavorable for the promotion and application of transdermal enhancers

Method used

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  • Multifunctional transdermal absorption promoter, and preparation method and application thereof
  • Multifunctional transdermal absorption promoter, and preparation method and application thereof
  • Multifunctional transdermal absorption promoter, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A multifunctional transdermal absorption accelerator, such as the compound shown in formula (I):

[0037]

[0038] In this example, among the compounds represented by formula (I), m is 3, X is 3, Y is 6, and Z is 500.

[0039] In this embodiment, the multifunctional transdermal absorption accelerator is nanoparticles with an average particle diameter of 150 nm.

[0040] A preparation method of the multifunctional transdermal absorption accelerator in the above-mentioned embodiments of the present invention, comprising the following steps:

[0041] (1) Dissolve 20g of chitosan in 100mL of tetrahydrofuran, add 5g of methanesulfonic acid chloride dropwise at 0°C, react for 12 hours, suspend and distill off tetrahydrofuran, dissolve the resulting product in chloroform again, and wash 3 times with water (100mL / time), dried over anhydrous sodium sulfate, suspended and evaporated to remove chloroform, to obtain 21g of crude product A. Dissolve the crude product A in 100m...

Embodiment 2

[0048] A multifunctional transdermal absorption accelerator, which is basically the same as the multifunctional transdermal absorption accelerator in Example 1, the only difference being that in the multifunctional transdermal absorption accelerator in Example 2, m is 2, X is 2, and Y is 7 and Z is 20.

Embodiment 3

[0050] A multifunctional transdermal absorption accelerator, which is basically the same as the multifunctional transdermal absorption accelerator in Example 1, the only difference being that in the multifunctional transdermal absorption accelerator in Example 3, m is 4, X is 6, and Y is 4 and Z is 1000.

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Abstract

The invention discloses a multifunctional transdermal absorption promoter, and a preparation method and application thereof. The multifunctional transdermal absorption promoter is a compound shown ina formula (I). The preparation method comprises the following steps: firstly, performing a reaction on chitosan subjected to pegylation and vitamin E to prepare vitamin E-linked chitosan, and then adding hyaluronic acid to perform a reaction to prepare the multifunctional transdermal absorption promoter. The multifunctional transdermal absorption promoter provided by the invention can obviously improve water solubility of insoluble nutrients in cosmetics, also has a good effect of promoting transdermal absorption, and has the advantages of low cost, good transdermal absorption promotion effect, good moisturizing effect, good biocompatibility, biodegradability and the like. The multifunctional transdermal absorption promoter is a new transdermal absorption promoter, can be applied to preparation of cosmetics and transdermal drug delivery preparations, and has a high application value and a good application prospect. The preparation method has the advantages of simple process, convenientoperation, easy availability of raw materials, low cost and the like, is suitable for large-scale preparation, and is beneficial to industrial application.

Description

technical field [0001] The invention relates to a multifunctional transdermal absorption accelerator and its preparation method and application. Background technique [0002] A lot of nutrients are added to skin care products. However, as long as these nutrients cannot be absorbed by the skin, they will become a burden on the skin. This is because the excess nutrients that cannot be absorbed by the skin will cause "skin oxidation" , not only can not play the role of delaying aging, but will accelerate the aging of the skin. Bacteria on the skin surface need a large amount of vitamins, proteins and biological cell nutrients in the process of growth and reproduction, and these are the main components of nutraceuticals. If the nutritional ingredients of cosmetics cannot be completely absorbed by the skin, it will become a breeding ground for the growth and reproduction of parasitic bacteria, and a large number of bacteria will also cause skin infections. In addition, in the e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/67A61Q19/00A61Q17/00A61K47/36A61K47/22A61K9/00C08G81/00
CPCA61K8/736A61K8/678A61K8/735A61Q19/00A61Q17/005A61K47/36A61K47/22A61K9/0014C08G81/00A61K2800/49
Inventor 杜立波
Owner 杜立波
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