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Application of micafungin in preparation of anti-tumor drug and anti-tumor drug

An anti-tumor drug, the technology of micafungin, is applied in the field of biomedicine to achieve obvious effects, inhibit the growth of tumor cells, and enhance the effect of anti-tumor effect

Active Publication Date: 2020-03-13
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, whether micafungin has a direct antitumor effect has not been reported

Method used

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  • Application of micafungin in preparation of anti-tumor drug and anti-tumor drug
  • Application of micafungin in preparation of anti-tumor drug and anti-tumor drug
  • Application of micafungin in preparation of anti-tumor drug and anti-tumor drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Cell experiment: Inhibitory effect of micafungin on tumor cell growth.

[0033] Implemented drugs: Micafungin was purchased from a reagent company.

[0034] Tumor cell lines: human breast cancer cell MCF-7, human glioma cell line T98G, human pancreatic cancer cell PANC1, human breast cancer cell MDA-MB-231, human breast cancer cell SK-BR-3, human lung cancer cell Strain A549 and human liver cancer cell HepG2 were purchased from the company.

[0035] Cell culture method: Carry out according to conventional method, specifically, above-mentioned cells are cultured in DMEM medium (containing 10% fetal calf serum, 100U / mL penicillin and streptomycin), when cell confluence grows to 90%, use trypsin Digestion, after the cells shrunk and rounded, and the intercellular space is obvious, stop the digestion with the medium immediately, break up the cells and blow them into a single suspension state, separate the bottles for passage, and store at 37°C, containing 5% CO ...

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Abstract

The invention relates to application of micafungin in the preparation of an anti-tumor drug and an anti-tumor drug. Micafungin can promote the death of tumor cells and inhibit the growth of tumor cells, and has an anti-tumor effect. Mikafungin can enhance the anti-tumor effect of other anti-tumor drugs when combined with the anti-tumor drugs, especially combined with cytotoxic anti-tumor drugs such as drugs that affect DNA structure and function such as cisplatin, drugs that interfere with the transcription process and prevent RNA synthesis such as doxorubicin, tyrosine kinase inhibitors suchas ponatinib and / or pazopanib, and drugs that inhibit protein synthesis and function such as paclitaxel. The Mikafungin can enhance the anti-tumor effect of these drugs.

Description

technical field [0001] The invention relates to the application of micafungin in the preparation of antitumor drugs and the antitumor drugs, belonging to the field of biomedicine. Background technique [0002] Micafungin is a semi-synthetic echinocandin antifungal drug, which can inhibit the formation of fungal cell walls. It inhibits 1,3-β-D glucan, an essential component of fungal cell walls, through non-competitive inhibition of glucan synthase Synthesis, with anti-Candida, Aspergillus activity. Compared with similar drugs, it has a broader spectrum of antifungal activity, and has broad-spectrum antifungal activity against the main pathogenic fungi of deep fungal infections, Aspergillus and Candida, and has fewer adverse reactions. [0003] So far, whether micafungin has a direct antitumor effect has not been reported. Contents of the invention [0004] In view of the deficiencies in the prior art, one of the objectives of the present invention is to provide the appli...

Claims

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Application Information

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IPC IPC(8): A61K38/12A61P35/00A61P35/02A61K33/243A61K31/704A61K31/5025A61K31/506A61K31/337
CPCA61K38/12A61P35/00A61P35/02A61K33/243A61K31/704A61K31/5025A61K31/506A61K31/337A61K2300/00Y02A50/30
Inventor 罗秀菊黄钰琳王倩琳彭军张议月唐励静刘斌彭靖杰涂画
Owner CENT SOUTH UNIV
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