Mass spectrometry detection method of plasma or tissue concentration of seven components of compound salvia miltiorrhiza preparation
A compound salvia miltiorrhiza and detection method technology, applied in the direction of measuring devices, material separation, and analysis of materials, can solve problems such as difficult handling and detection, large content differences, and complicated processes, and achieve good practical significance, high separation, and Simple operation effect
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[0032] (1) Preparation of stock solution:
[0033] Take standard products Tanshinone I, Tanshinone IIA, Salvianolic acid B, Danshensu, Panax notoginseng R 1 , Ginsenoside Rg 1 and Rb 1 , respectively dissolved in (80±5)% methanol aqueous solution to prepare standard stock solution; mix the standard stock solution to obtain mixed standard stock solution;
[0034] Dissolve carbamazepine in (80±5)% methanol aqueous solution to prepare carbamazepine stock solution;
[0035] (2) Preparation of working solution:
[0036] Dilute the mixed standard stock solution with (80±5)% methanol aqueous solution respectively to prepare a mixed standard curve sample working solution and a mixed quality control sample working solution;
[0037] Dilute the carbamazepine stock solution with (80±5)% methanol aqueous solution to prepare an internal standard working solution;
[0038] (3) Preparation of sample solution to be tested:
[0039] Preparation of the plasma sample solution to be tested:...
Embodiment 1
[0092] (1) Preparation of solution
[0093] Preparation of stock solutions:
[0094] Weigh an appropriate amount of the main components of compound Danshen preparation, Tanshinone I, Tanshinone IIA, Salvianolic acid B, Danshensu, Panax notoginseng saponin R 1 , Ginsenoside Rg 1 , Ginsenoside Rb 1 The standard products were respectively dissolved in an appropriate amount of 80% methanol aqueous solution to prepare standard product stock solutions with a concentration of 1.00 mg / mL. Mix the seven standard stock solutions with a concentration of 1.00 mg / mL in equal volumes, and add an appropriate amount of 80% methanol aqueous solution to prepare a mixed standard stock solution with a concentration of 0.100 mg / mL for the seven components.
[0095] Take an appropriate amount of carbamazepine standard and dissolve it in 80% methanol aqueous solution to prepare a carbamazepine stock solution with a concentration of 1.00 mg / mL.
[0096] Preparation of standard curve working solut...
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