Mass spectrometry detection method of plasma or tissue concentration of seven components of compound salvia miltiorrhiza preparation

A compound salvia miltiorrhiza and detection method technology, applied in the direction of measuring devices, material separation, and analysis of materials, can solve problems such as difficult handling and detection, large content differences, and complicated processes, and achieve good practical significance, high separation, and Simple operation effect
CN110907581BActive Publication Date: 2022-07-01GUANGZHOU PHARMACEUTICAL INDUSTRIAL RESEARCH INSTITUTE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
GUANGZHOU PHARMACEUTICAL INDUSTRIAL RESEARCH INSTITUTE
Publication Date
2022-07-01

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Abstract

The invention relates to a mass spectrometry detection method for plasma or tissue concentrations of seven components of a compound salvia miltiorrhiza preparation. The method includes the following steps: (1) Preparation of stock solution: take standard products Tanshinone I, Tanshinone IIA, salvianolic acid B, Danshensu, and Panax notoginseng saponins R 1 , Ginsenoside Rg 1 and Rb 1 , were dissolved in (80±5)% methanol aqueous solution to prepare standard stock solution; carbamazepine was dissolved in (80±5)% methanol aqueous solution to prepare carbamazepine stock solution; (2) working solution (3) preparation of the sample solution to be tested; (4) separation of the sample solution to be tested obtained in step (3) by liquid chromatography; and mass spectrometry analysis of the sample separated by liquid chromatography. In the detection process of the method of the invention, the chromatographic peak shape is excellent, and the channel of each compound has only a unique target peak, which avoids other interferences such as solvent effects, and has the advantages of simple operation, rapid analysis, high specificity and high resolution.
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Description

technical field

[0001] The invention relates to the technical field of drug analysis, in particular to a mass spectrometry detection method for the plasma or tissue concentrations of seven components of a compound Danshen preparation. Background technique

[0002] Compound Danshen preparation is composed of three traditional Chinese medicines: Danshen, Panax notoginseng and borneol. There are 9 kinds of dosage forms: Compound Danshen Oral Liquid, Compound Danshen Aerosol, Compound Danshen Buccal Tablets, Compound Danshen Capsules, Compound Danshen Tablets, Compound Danshen Granules, Compound Danshen Dropping pills, compound salvia spray, compound salvia soft capsules. Compound Danshen preparation has the effects of promoting blood circulation and removing blood stasis, regulating qi and relieving pain. It is used for chest pain caused by stagnation of qi and blood stasis. In clinical application, the incidence of adverse reactions with compound Danshen preparation alone is ...

Claims

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