Double-bond-containing six-arm star polymer and its preparation method and diselenide cross-linked micelle/nano-gold system

A technology of star-shaped polymers and micelles, which is applied in the field of diselenium cross-linked micelles/nano-gold system, can solve the problem of long-term stability, the stability of nano-gold and the integrated performance of diagnosis and treatment. There is no in-depth and systematic research and other problems, to achieve the effect of tumor imaging diagnosis, efficient reduction and stability, and good stability

Active Publication Date: 2022-07-05
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the long-term stability of these systems needs to be studied
Moreover, there is no in-depth and systematic research on the influence of selenium content, polymer molecular weight, concentration, etc. on the stability of gold nanoparticles and the integrated performance of diagnosis and treatment.

Method used

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  • Double-bond-containing six-arm star polymer and its preparation method and diselenide cross-linked micelle/nano-gold system
  • Double-bond-containing six-arm star polymer and its preparation method and diselenide cross-linked micelle/nano-gold system
  • Double-bond-containing six-arm star polymer and its preparation method and diselenide cross-linked micelle/nano-gold system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Example 1: Six-arm star polymer containing double bonds (PCL-(PHEMA-A)-PPEGMA) 6 preparation

[0064] (1) Preparation of macromolecular initiator (PCL) 6 : Weigh dipentaerythritol (0.0381 g, 0.15 mmol) and add it to a 100 mL eggplant-shaped bottle together with a stirrer, and seal it with a rubber stopper. Then vacuum-purge argon three times; in the environment of inert gas, first add monomer ε-CL (43.2g, 7.2mmol), then add 0.0432g stannous octoate, and then perform three times of freezing through liquid nitrogen-pumping- After the heating cycle, the reaction was carried out in an oil bath at 150 °C for 24 h; after 24 h, after the eggplant-shaped flask was cooled to room temperature, the toluene was evaporated by vacuum distillation, and then dissolved in 75 mL of tetrahydrofuran. The tetrahydrofuran was removed by a rotary evaporator, and the obtained liquid was added dropwise to 500 mL of cold methanol for precipitation, and finally dried under vacuum for 24 h to ob...

Embodiment 2

[0080] Example 2: Double bond modified six-arm star polymer (PCL-(PHEMA-A)-PPEGMA) 6 preparation

[0081] (1) Preparation of macromolecular initiator (PCL) 6 : Weigh dipentaerythritol (0.0381 g, 0.15 mmol) and add it to a 100 mL eggplant-shaped bottle together with a stirrer, and seal it with a rubber stopper. Then evacuate-argon three times. In the environment of inert gas, the monomer ε-CL (32.4g, 5.4mmol) was added first, then 0.0324g stannous octoate was added, and after three cycles of freezing-pumping-heating through liquid nitrogen, the oil at 130°C was The reaction was carried out in the bath for 24h. After 24 hours, after the eggplant-shaped bottle was cooled to room temperature, the toluene was evaporated by vacuum distillation, and then dissolved in 75 mL of tetrahydrofuran. After it was completely dissolved, the tetrahydrofuran was removed by a rotary evaporator. Precipitation in methanol, and finally vacuum drying for 24h to obtain the product (PCL) 6 . The ...

Embodiment 3

[0085] Example 3: Double bond modified six-arm star polymer (PCL-(PHEMA-A)-PPEGMA) 6 preparation

[0086] (1) Preparation of macromolecular initiator (PCL) 6 : Weigh dipentaerythritol (0.0381 g, 0.15 mmol) and add it to a 100 mL eggplant-shaped bottle together with a stirrer, and seal it with a rubber stopper. Then evacuate-argon three times. In the environment of inert gas, first add monomer ε-CL (81g, 13.5mmol), then add 0.081g stannous octoate, and then carry out three cycles of freezing-pumping-heating through liquid nitrogen, then in an oil bath of 130 ° C The reaction was carried out for 48h. After 48 hours, after the eggplant-shaped bottle was cooled to room temperature, the toluene was evaporated by vacuum distillation, and then dissolved in 75 mL of tetrahydrofuran. After it was completely dissolved, the tetrahydrofuran was removed by a rotary evaporator. Precipitation in methanol, and finally vacuum drying for 24h to obtain the product (PCL) 6 . The synthetic r...

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Abstract

The invention belongs to the technical field of biomedical macromolecular polymer materials, and discloses a six-arm star polymer containing double bonds, a preparation method thereof, and a diselenide cross-linked micelle / nano-gold system. The double-bond-containing six-arm star polymer has the structure shown in formula (1), where x=6-18, y=6-15, z=6-15, and n=5-8. The polymer is easy to control the ratio of each block, and can prepare cross-linked micelles with stable structure and small particle size. The present invention also provides in-situ preparation of gold nanoparticles with small particle size and good stability based on the polymer cross-linked micelle system. This diselenide cross-linked micelle / nano-gold system is expected to be used as a nano-carrier in the integration of diagnosis and treatment system. R 4 for:

Description

technical field [0001] The invention belongs to the technical field of biomedical macromolecular polymer materials, in particular to a six-arm star polymer containing double bonds, a preparation method thereof, and a diselenide cross-linked micelle / nano-gold system. Background technique [0002] The integrated system of cancer diagnosis and treatment is to deliver cancer drugs and contrast agents to the lesions at the same time. Selenium (Se) is the third element of the oxygen group. Compared with oxygen and sulfur, the metallicity of selenium is enhanced rather than weakened, and it has unique redox properties. Polymer self-assembly and drug release, optoelectronic materials, catalysts, and organic synthesis, especially the synthesis of natural products, have rich and unique application prospects. Although selenium was discovered earlier, the related research progress is slow due to its easy oxidation and high toxicity of some compounds, and is limited by synthesis methods...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F293/00C08F220/20C08F220/28C08F8/10C08G63/664
CPCC08F293/005C08F220/20C08F220/28C08F8/10C08G63/664C08F2438/01
Inventor 易国斌林文静赵倩怡张洁恒李艳哲陈泽端
Owner GUANGDONG UNIV OF TECH
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