Establishment and application of novel blood multi-index liver cancer diagnosis model (GAP-TALAD)

A technology for diagnosing models and models, applied in the field of diagnosis, can solve problems such as unreported

Pending Publication Date: 2020-04-10
高春芳
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Problems solved by technology

[0004] International multi-centers have confirmed that diagnostic models can greatly improve the diagnostic efficiency of clinical single-index primary hepatocellular carcinoma, but these international multi-center studies have not focused on hepatitis B virus-related primary hepatocellular carcinoma, and more than 80% of our country’s original Hepatocellular carcinom

Method used

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  • Establishment and application of novel blood multi-index liver cancer diagnosis model (GAP-TALAD)
  • Establishment and application of novel blood multi-index liver cancer diagnosis model (GAP-TALAD)
  • Establishment and application of novel blood multi-index liver cancer diagnosis model (GAP-TALAD)

Examples

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Embodiment

[0016] Example: Establishing a model based on blood multi-index regression for distinguishing primary hepatocellular carcinoma from benign liver diseases.

[0017] (1) Sample collection

[0018] Collection of serum samples from patients with benign liver diseases: retrospective analysis, the training group was from January 2015 to December 2018 in our hospital with benign liver diseases (including cirrhosis, inflammatory pseudotumor, focal nodular hyperplasia, etc.) 1731 cases. The verification group consisted of 253 cases of liver cirrhosis in our hospital from September 2018 to August 2019. Among them, patients with cirrhosis meet the following inclusion criteria: refer to the "Guidelines for the Prevention and Treatment of Hepatitis B", clinical features or imaging diagnosis of cirrhosis; liver biopsy diagnostic criteria suggest the presence of cirrhosis; basic information of all cases is complete; liver cancer is excluded and other organ malignancies.

[0019] Collectio...

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Abstract

The invention discloses establishment and application of a novel blood multi-index liver cancer diagnosis model (GAP-TALAD). The invention belongs to the technical field of diagnosis, and relates to establishment and application of a primary hepatocellular carcinoma diagnosis model, in particular to establishment and application of a primary hepatocellular carcinoma early warning model based on test data, and the model can be used for distinguishing primary hepatocellular carcinoma from benign liver diseases.

Description

technical field [0001] The invention belongs to the technical field of diagnosis, and relates to the establishment and application of a primary hepatocellular carcinoma diagnostic model, in particular to the establishment and application of a primary hepatocellular carcinoma early warning model based on clinical test data, which can be used to distinguish primary hepatocellular carcinoma Hepatocellular carcinoma and benign liver disease. Background technique [0002] Primary liver cancer mainly includes different pathological types such as hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and mixed hepatocellular carcinoma-intrahepatic cholangiocarcinoma (HCC-ICC). Accounted for more than 90%. At present, serum alpha-fetoprotein (AFP) detection combined with ultrasonography is used clinically to monitor high-risk groups, so that some patients with primary hepatocellular carcinoma can be preliminarily screened in the subclinical stage. However, the curre...

Claims

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Application Information

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IPC IPC(8): G16H50/20G16H50/70G06F17/18
CPCG06F17/18G16H50/20G16H50/70
Inventor 高春芳童林房萌黄晨军高致远季君孙小娟
Owner 高春芳
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