Novel uses of piperidinyl-indole derivatives

A technology of indole and methyl, used in the field of treating patients with C3G and IgAN, can solve the problems of no description of application, no description of piperidinyl-indole derivatives, etc.

Pending Publication Date: 2020-04-17
NOVARTIS AG
View PDF5 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no description about the use of piperidinyl-indole derivatives in other renal diseases, which is a separate case, with a causal relationship significantly different from the above, especially it is not described in the classic HUS (Escherichia coli-induced hemolysis Uremic syndrome) and membranous nephropathy

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel uses of piperidinyl-indole derivatives
  • Novel uses of piperidinyl-indole derivatives

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0007] In the first embodiment, the present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof for use in the treatment of complement-driven renal disease C3G (C3 glomerulopathy), IgAN (immunoglobulin) A nephropathy) and other nephropathy with signs of glomerular C3 deposition (such as MN (membranous nephropathy) and HUS (E. coli-induced hemolytic uremic syndrome)). The compound of formula (I) or a pharmaceutically acceptable salt thereof is represented by the following structure:

[0008]

[0009] among them

[0010] R is hydrogen, C 1 -C 4 Alkyl, or C 1 -C 6 Alkoxy;

[0011] R 1 Is C 1 -C 6 Alkoxy;

[0012] R 2 Is C 1 -C 6 alkyl;

[0013] R 3 Is C 1 -C 6 Alkoxy; C 1 -C 6 Alkyl; or hydroxyl;

[0014] R 4 Is optionally -C(O)R 8 Substituted phenyl, and

[0015] R 8 Is hydroxyl, C 1 -C 4 Alkoxy or amino.

[0016] In a second embodiment, the present invention provides a compound for use according to the first embodiment or a pharmaceutically acceptabl...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention relates to the novel use of certain piperidinyl-indole derivatives in the treatment of patients suffering from renal diseases or disorders, and in particular for the treatment ofpatients suffering from C3G (C3 glomerulopathy) and IgAN (IgA nephropathy).

Description

Technical field [0001] The present invention relates to the use of certain piperidinyl-indole derivatives in the treatment of patients suffering from disorders and diseases (such as renal diseases) associated with the activation of the alternative pathway of complement, and particularly in the treatment of patients suffering from C3G (C3 renal small Globulin) and IgAN (immunoglobulin A nephropathy). Background technique [0002] The complement system is an important part of the innate immune system and contains a series of proteases that normally exist in an inactive state. These proteases are organized in three activation pathways: classic, lectin, and all alternative pathways that converge on the C3 and C5 cleavage and common terminal pathways (VMHolers, In Clinical Immunology: Principles and Practice [Clinical Immunology: Principles and Practice] Practice], editor RRRich, Mosby Press [Mosby Press]; 1996, 363-391). Molecules, antibodies, or cellular components from microorgan...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/454A61P13/12
CPCA61K31/454A61P13/12Y02A50/30
Inventor J·埃德R·A·哈里森B·哈拉尔松A·S·舒巴特
Owner NOVARTIS AG
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap