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Novel uses of piperidinyl-indole derivatives

A technology of indole and methyl, used in the field of treating patients with C3G and IgAN, can solve the problems of no description of application, no description of piperidinyl-indole derivatives, etc.

Pending Publication Date: 2020-04-17
NOVARTIS AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no description about the use of piperidinyl-indole derivatives in other renal diseases, which is a separate case, with a causal relationship significantly different from the above, especially it is not described in the classic HUS (Escherichia coli-induced hemolysis Uremic syndrome) and membranous nephropathy

Method used

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  • Novel uses of piperidinyl-indole derivatives
  • Novel uses of piperidinyl-indole derivatives

Examples

Experimental program
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Embodiment Construction

[0007] In the first embodiment, the present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof for use in the treatment of complement-driven renal disease C3G (C3 glomerulopathy), IgAN (immunoglobulin) A nephropathy) and other nephropathy with signs of glomerular C3 deposition (such as MN (membranous nephropathy) and HUS (E. coli-induced hemolytic uremic syndrome)). The compound of formula (I) or a pharmaceutically acceptable salt thereof is represented by the following structure:

[0008]

[0009] among them

[0010] R is hydrogen, C 1 -C 4 Alkyl, or C 1 -C 6 Alkoxy;

[0011] R 1 Is C 1 -C 6 Alkoxy;

[0012] R 2 Is C 1 -C 6 alkyl;

[0013] R 3 Is C 1 -C 6 Alkoxy; C 1 -C 6 Alkyl; or hydroxyl;

[0014] R 4 Is optionally -C(O)R 8 Substituted phenyl, and

[0015] R 8 Is hydroxyl, C 1 -C 4 Alkoxy or amino.

[0016] In a second embodiment, the present invention provides a compound for use according to the first embodiment or a pharmaceutically acceptabl...

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Abstract

The present invention relates to the novel use of certain piperidinyl-indole derivatives in the treatment of patients suffering from renal diseases or disorders, and in particular for the treatment ofpatients suffering from C3G (C3 glomerulopathy) and IgAN (IgA nephropathy).

Description

Technical field [0001] The present invention relates to the use of certain piperidinyl-indole derivatives in the treatment of patients suffering from disorders and diseases (such as renal diseases) associated with the activation of the alternative pathway of complement, and particularly in the treatment of patients suffering from C3G (C3 renal small Globulin) and IgAN (immunoglobulin A nephropathy). Background technique [0002] The complement system is an important part of the innate immune system and contains a series of proteases that normally exist in an inactive state. These proteases are organized in three activation pathways: classic, lectin, and all alternative pathways that converge on the C3 and C5 cleavage and common terminal pathways (VMHolers, In Clinical Immunology: Principles and Practice [Clinical Immunology: Principles and Practice] Practice], editor RRRich, Mosby Press [Mosby Press]; 1996, 363-391). Molecules, antibodies, or cellular components from microorgan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/454A61P13/12
CPCA61K31/454A61P13/12Y02A50/30
Inventor J·埃德R·A·哈里森B·哈拉尔松A·S·舒巴特
Owner NOVARTIS AG