A kind of sound sensitizer with aggregation-induced luminescent property and preparation method thereof

An aggregation-induced luminescence and sonosensitizer technology, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, and preparations for in vivo tests, etc. Oxygen generation reduction and other problems, to achieve the effect of expanding the range

Active Publication Date: 2021-10-08
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, another way to improve the efficacy of photo / sound sensitizers is to increase the load of photo / sound sensitizers, but the overload of organic molecules can easily lead to the quenching of photo / sound sensitizers, and the quenching effect caused by aggregation can also lead to active The reduction of oxygen generation has become the bottleneck problem faced by sound sensitizers

Method used

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  • A kind of sound sensitizer with aggregation-induced luminescent property and preparation method thereof
  • A kind of sound sensitizer with aggregation-induced luminescent property and preparation method thereof
  • A kind of sound sensitizer with aggregation-induced luminescent property and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The preparation of the sonosensitizer with AIE characteristic comprises the following steps:

[0040] 1) Add 0.2 mg of the prepared fluorophore molecule TTMN with aggregation-induced luminescent properties into the organic solvent tetrahydrofuran to dissolve it;

[0041] 2) Add 3 mg distearoylphosphatidylethanolamine-polyethylene glycol-2000 (PEG-DSPE) to the above solution 2000 ) and stir evenly to obtain 1mL mixed solution;

[0042] 3) Add 1 mL of the above mixed solution into 10 mL of pure water and stir at room temperature for 8 hours to volatilize the organic solvent in the water and self-assemble to form nanoparticles;

[0043] 4) After the obtained solution is ultrafiltered, the above-mentioned sound sensitizer with aggregation-induced luminescent properties is obtained, and its core-shell structure is as follows: figure 1 shown.

[0044] figure 2 Electron micrograph of the sound sensitizer with aggregation-induced luminescent properties prepared in this exa...

Embodiment 2

[0052] The preparation of the sonosensitizer with AIE characteristic comprises the following steps:

[0053] 1) Add 0.2 mg of the prepared fluorophore molecule MeTTMN with AIE characteristics into the organic solvent tetrahydrofuran to dissolve it;

[0054] 2) Add 3 mg distearoylphosphatidylethanolamine-polyethylene glycol-5000 (PEG-DSPE) to the above solution 5000 ) and stir evenly to obtain 1mL mixed solution;

[0055] 3) Add 1 mL of the above mixed solution into 10 mL of pure water and stir at room temperature for 8 hours to volatilize the organic solvent in the water and self-assemble to form nanoparticles;

[0056] 4) After the obtained solution is ultra-filtered, the above-mentioned sonosensitizer with aggregation-induced luminescent properties is obtained.

[0057] Using DPBF as a probe for singlet oxygen, the ability of the sonosensitizer with AIE characteristics described in 4) to degrade DPBF under ultrasonic irradiation was investigated. The ultrasonic conditions...

Embodiment 3

[0059] The preparation of the sonosensitizer with AIE characteristic comprises the following steps:

[0060] 1) Add 0.2 mg of the prepared fluorophore molecule MeOTTMN with AIE characteristics into the organic solvent DMSO to dissolve it;

[0061] 2) Add 3 mg distearoylphosphatidylethanolamine-polyethylene glycol-2000 (PEG-DSPE) to the above solution 2000 ) and stir evenly to obtain 1mL mixed solution;

[0062] 3) Add 1 mL of the above mixed solution into 10 mL of pure water and stir at room temperature for 8 hours to volatilize the organic solvent in the water and self-assemble to form nanoparticles;

[0063] 4) After the obtained solution is ultra-filtered, the above-mentioned sonosensitizer with aggregation-induced luminescent properties is obtained.

[0064] Using DPBF as a probe for singlet oxygen, the ability of the sonosensitizer with AIE characteristics described in 4) to degrade DPBF under ultrasonic irradiation was investigated. The ultrasonic conditions used are ...

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Abstract

The invention relates to a sound sensitizer with aggregation-induced luminescence characteristics and a preparation method thereof. The sound sensitizer has a core-shell structure, the inner core is a fluorophore molecule with aggregation-induced luminescence characteristics, and the outer shell is a hydrophilic substance; The preparation method includes the following steps: 1) dissolving fluorophore molecules with aggregation-induced luminescent properties in an organic solvent, then adding a hydrophilic substance, and mixing uniformly to obtain a mixed solution; 2) adding the mixed solution to water, and then stirring to A core-shell structure is formed, and a sound-sensitizer with aggregation-induced luminescent properties is obtained after separation. Compared with the prior art, the sonosensitizer prepared by the present invention has no fluorescence quenching effect, so it can generate more singlet oxygen to inhibit tumor growth during the sonodynamic therapy; due to the characteristics of the AIE molecule itself, it can introduce fluorescence Navigation interventional therapy; at the same time, there are many kinds of AIE molecules, so the range of sound sensitizers can be expanded.

Description

technical field [0001] The invention belongs to the technical field of functional materials and medicines, and relates to a sound sensitizer with aggregation-induced luminescent properties and a preparation method thereof. Background technique [0002] The high morbidity and mortality of malignant tumors have seriously threatened human life and health, so it is urgent to find an effective treatment method for malignant tumors. Currently, there are certain drawbacks in the clinically applied means of treating malignant tumors, such as surgical resection, radiotherapy, and chemotherapy. In recent years, photodynamic therapy, a minimally invasive treatment method, has entered people's field of vision, but light decays very quickly in tissues and cannot penetrate deep tissues, so the photosensitizers accumulated in deep tissues cannot be fully excited to generate enough reactive oxygen species. Kill tumor cells. [0003] Acoustodynamic therapy developed on the basis of photody...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/24A61K47/04A61K47/32A61K47/42A61K49/00A61P35/00
CPCA61K9/5138A61K9/5146A61K9/5169A61K41/0033A61K49/0021A61K49/0093A61P35/00
Inventor 张兵波曾维薇杨维涛徐琰
Owner TONGJI UNIV
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