Sound-sensitive agent with aggregation-induced emission characteristics and preparation method thereof

A technology for aggregation-induced luminescence and sound sensitizers, applied to medical preparations containing active ingredients, preparations for in vivo tests, and pharmaceutical formulations, etc., can solve the problem of quenching of light/sound sensitizers, reduction of active oxygen generation, etc. problem, to achieve the effect of expanding the range

Active Publication Date: 2020-04-24
TONGJI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, another way to improve the efficacy of photo/sound sensitizers is to increase the load of photo/sound sensitizers, but the overload of organic molecules can easily lead to the quenchin

Method used

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  • Sound-sensitive agent with aggregation-induced emission characteristics and preparation method thereof
  • Sound-sensitive agent with aggregation-induced emission characteristics and preparation method thereof
  • Sound-sensitive agent with aggregation-induced emission characteristics and preparation method thereof

Examples

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Example Embodiment

[0038] Example 1:

[0039] The preparation of a sonosensitizer with AIE characteristics includes the following steps:

[0040] 1) Add 0.2 mg of the prepared fluorophore molecule TTMN with aggregation-induced luminescence characteristics into the organic solvent tetrahydrofuran to dissolve it;

[0041] 2) Add 3mg distearoylphosphatidylethanolamine-polyethylene glycol-2000 (PEG-DSPE 2000 ) And stir evenly to obtain 1 mL of mixed solution;

[0042] 3) Add the above 1mL mixed solution to 10mL of pure water and stir for 8h at room temperature to volatilize the organic solvent in the water and self-assemble to form nanoparticles;

[0043] 4) After the obtained solution is ultrafiltered, the sonosensitizer with aggregation-induced luminescence characteristics is obtained, and the core-shell structure is as figure 1 Shown.

[0044] figure 2 This is the electron micrograph of the sonosensitizer with aggregation-induced luminescence properties prepared in this example, which is represented by fi...

Example Embodiment

[0051] Example 2:

[0052] The preparation of a sonosensitizer with AIE characteristics includes the following steps:

[0053] 1) Add 0.2 mg of the prepared fluorophore molecule MeTTMN with AIE characteristics to the organic solvent tetrahydrofuran to dissolve it;

[0054] 2) Add 3mg distearoylphosphatidylethanolamine-polyethylene glycol-5000 (PEG-DSPE 5000 ) And stir evenly to obtain 1 mL of mixed solution;

[0055] 3) Add the above 1mL mixed solution to 10mL of pure water and stir for 8h at room temperature to volatilize the organic solvent in the water and self-assemble to form nanoparticles;

[0056] 4) After the obtained solution is ultrafiltered, the sonosensitizer with aggregation-induced luminescence characteristics is obtained.

[0057] Using DPBF as a probe for singlet oxygen, the ability of the sonosensitizer with AIE characteristics described in 4) to degrade DPBF under ultrasonic irradiation was investigated. The ultrasonic conditions used are 1.5MHz, power 2W / cm 2 , The to...

Example Embodiment

[0058] Example 3:

[0059] The preparation of a sonosensitizer with AIE characteristics includes the following steps:

[0060] 1) Add 0.2mg of the prepared fluorophore molecule MeOTTMN with AIE characteristics to the organic solvent DMSO to dissolve it;

[0061] 2) Add 3mg distearoylphosphatidylethanolamine-polyethylene glycol-2000 (PEG-DSPE 2000 ) And stir evenly to obtain 1 mL of mixed solution;

[0062] 3) Add the above 1mL mixed solution to 10mL of pure water and stir for 8h at room temperature to volatilize the organic solvent in the water and self-assemble to form nanoparticles;

[0063] 4) After the obtained solution is ultrafiltered, the sonosensitizer with aggregation-induced luminescence characteristics is obtained.

[0064] Using DPBF as a probe for singlet oxygen, the ability of the sonosensitizer with AIE characteristics described in 4) to degrade DPBF under ultrasonic irradiation was investigated. The ultrasonic conditions used are 2.0MHz, power 1.5W / cm 2 , The total expos...

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Abstract

The invention relates to a sound-sensitive agent with aggregation-induced emission characteristics and a preparation method thereof. The sound-sensitive agent has a core-shell structure: the inner core is fluorophore molecules with aggregation-induced emission characteristics, and the outer shell is a hydrophilic substance. The preparation method of the sound-sensitive agent comprises the following steps: 1) dissolving the fluorophore molecules with aggregation-induced emission characteristics in an organic solvent, then adding the hydrophilic substance, and uniformly mixing to obtain a mixedsolution; and 2) adding the mixed solution into water, stirring to form a core-shell structure, and separating to obtain the sound-sensitive agent with aggregation-induced emission characteristics. Compared with the prior art, the prepared sound-sensitive agent has no fluorescence quenching effect, so that more singlet oxygen can be generated in the sonodynamic therapy process to inhibit tumor growth; due to the characteristics of the AIE molecules, fluorescence navigation interventional therapy can be introduced; meanwhile, the AIE molecules are various in variety, so that the range of the sound-sensitive agent can be expanded.

Description

technical field [0001] The invention belongs to the technical field of functional materials and medicines, and relates to a sound sensitizer with aggregation-induced luminescent properties and a preparation method thereof. Background technique [0002] The high morbidity and mortality of malignant tumors have seriously threatened human life and health, so it is urgent to find an effective treatment method for malignant tumors. Currently, there are certain drawbacks in the clinically applied means of treating malignant tumors, such as surgical resection, radiotherapy, and chemotherapy. In recent years, photodynamic therapy, a minimally invasive treatment method, has entered people's field of vision, but light decays very quickly in tissues and cannot penetrate deep tissues, so the photosensitizers accumulated in deep tissues cannot be fully excited to generate enough reactive oxygen species. Kill tumor cells. [0003] Acoustodynamic therapy developed on the basis of photody...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/51A61K49/00A61P35/00
CPCA61K9/5138A61K9/5146A61K9/5169A61K41/0033A61K49/0021A61K49/0093A61P35/00
Inventor 张兵波曾维薇杨维涛徐琰
Owner TONGJI UNIV
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