Composition containing orlistat and alginic acid or derivatives of alginic acid and application of composition
A technology of orlistat and alginic acid, which is applied in the field of medicine, can solve the problem of low content of active ingredients, achieve the effect of improving treatment outcomes and reducing treatment costs
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preparation example 1
[0023] The preparation of preparation example 1 green plum flower extract
[0024] The green plum flower used in the present invention is the Da Yeqing variety in Xiaoshan Daqingmei, which is collected from Meilin, Huaxing Town, Xiaoshan District, Hangzhou City, Zhejiang Province. After picking, it is vacuum-dried in time (with a water content below 10%), and stored at room temperature in the dark.
[0025] The green plum flower raw material is dried, crushed with a universal Chinese medicine pulverizer, and passed through a 40-mesh sieve, and 1 kg is taken, and ethanol (30%, v / v) is added to make the material-liquid ratio=1:10, w / v, at 60-70°C Reflux extraction for 2 hours, extract twice under the same conditions, combine the two extracts, concentrate under reduced pressure and freeze-dry to obtain a brown powder sample, then vacuum-sealed and packaged, the radiation source is 60Co-γ, and the radiation dose is 6kGy , sterilized by irradiation and stored in a refrigerator at 4...
preparation example 2
[0026] Preparation Example 2 Preparation of medium and low molecular weight alginic acid or its derivatives from commercially available high molecular weight alginic acid or its derivatives
[0027] The present invention firstly purchases high molecular weight alginic acid or its derivatives whose molecular weight is shown in Table 1 through GPC method through commercial channels, and uses the lowest molecular weight high molecular weight alginic acid or its derivatives in Table 1 as raw material through microwave-assisted Alginic acid or its derivatives with medium molecular weight were prepared by hydrogen peroxide degradation method.
[0028] Table 1 Commercially available high molecular weight alginic acid or its derivatives used in the present invention
[0029]
[0030]Add 1.5g of alginic acid or its derivatives to 100mL of deionized water, stir and mix well, let it stand overnight, add 30% hydrogen peroxide solution dropwise to the resulting solution, so that the fin...
preparation example 3
[0033] Preparation Example 3 Composition of Orlistat and Alginic Acid or Its Derivatives
[0034] Preparation Example 3 provides 7 groups of compositions containing orlistat, alginic acid or derivatives thereof, and the specific qualities of the compositions are shown in Table 2. Wherein orlistat (denoted as ORL) and the mass ratio of alginic acid or derivatives thereof shown in table 1, table 2 is the composition that α forms, and is denoted as composition A; PF and orlistat and alginic acid or its derivatives at a mass ratio of 1:0.5, which is referred to as composition B.
[0035] Table 3 Composition formula of orlistat and alginic acid or derivatives thereof
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[0044] Note: The mass ratio is: the mass ratio of orlistat to alginic acid and its derivatives, and the components are connected with "-" to indicate the mixture, the same below.
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