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A kind of preparation method of medical stone with epsilon-polylysine antibacterial coating on the surface

A polylysine and surface-loaded technology, which is applied in chemical instruments and methods, sterilization/microdynamic water/sewage treatment, and other chemical processes, can solve the problem of reduced adsorption capacity of medical stone, secondary pollution of metal ions, Problems such as secondary pollution of water quality, to achieve the effect of eliminating secondary pollution, high safety, and easy raw materials

Active Publication Date: 2020-09-04
JIANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, there is an obvious problem in using medical stone to purify water, that is, the secondary pollution of water quality
Because in the process of medical stone treatment of water, the microorganisms adsorbed by the medical stone can multiply rapidly on the surface of the medical stone, thus covering the surface of the medical stone. On the one hand, the adsorption capacity of the medical stone is reduced, and on the other hand, the microbial Large numbers of breeding cause secondary pollution of water quality
In the prior art, metal ions are loaded onto medical stones as bacteriostatic agents. There are medical stones such as silver-loaded, aluminum-loaded, and iron-loaded stones, but these metal ion bacteriostatic agents are not resistant to water erosion, and the dissolution rate is high, which is easy to cause metal ions. secondary pollution of ions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The invention provides a kind of preparation method of the medical stone of surface loading epsilon-polylysine bacteriostatic coating, comprises the following steps:

[0034] S1. Use absolute ethanol as a solvent to make 3-aminopropyltriethoxysilane into an amination solution with a concentration of 3%, and add 0.3% glacial acetic acid as a catalyst. The particle size is 60-80 mesh, and the surface The medical stone with microporous structure characteristics is immersed in the amination solution, the mass volume ratio of the medical stone to the amination solution is 30:100g / mL; the temperature is controlled at 60°C, reacted for 24h, and then Use a 100-mesh sieve to filter out the aminated medical stone, rinse with absolute ethanol for 10 minutes, then rinse with distilled water for 30 minutes, and dry at 105°C;

[0035] S2, the glutaraldehyde solution with a concentration of 25% is configured into a glutaraldehyde solution with a concentration of 2.5% with distilled wa...

Embodiment 2

[0039] The invention provides a kind of preparation method of the medical stone of surface loading epsilon-polylysine bacteriostatic coating, comprises the following steps:

[0040] S1. Use absolute ethanol as a solvent to make 3-aminopropyltriethoxysilane into an amination solution with a concentration of 1%, and add 0.1% glacial acetic acid as a catalyst. The particle size is 60-80 mesh, and the surface The medical stone with microporous structure is immersed in the amination solution, the mass volume ratio of the medical stone to the amination solution is 20:100g / mL; the temperature is controlled at 50°C, reacted for 48h, and then Use a 100-mesh sieve to filter out the aminated medical stone, rinse with absolute ethanol for 10 minutes, then rinse with distilled water for 30 minutes, and dry at 105°C;

[0041] S2, the glutaraldehyde solution with a concentration of 25% is configured into a glutaraldehyde solution with a concentration of 1.5% with distilled water, and sodium ...

Embodiment 3

[0045] The invention provides a kind of preparation method of the medical stone of surface loading epsilon-polylysine bacteriostatic coating, comprises the following steps:

[0046] S1. Use absolute ethanol as a solvent to make 3-aminopropyltriethoxysilane into an amination solution with a concentration of 3%, and add 0.1% glacial acetic acid as a catalyst. The particle size is 60-80 mesh, and the surface The medical stone with microporous structure characteristics is immersed in the amination solution, the mass volume ratio of the medical stone to the amination solution is 50:100g / mL; the temperature is controlled at 60°C, reacted for 24h, and then Use a 100-mesh sieve to filter out the aminated medical stone, rinse with absolute ethanol for 10 minutes, then rinse with distilled water for 30 minutes, and dry at 105°C;

[0047] S2, the glutaraldehyde solution with a concentration of 25% is configured into a glutaraldehyde solution with a concentration of 3% with distilled wate...

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Abstract

The invention provides a method for preparing medical stone with ε-polylysine antibacterial coating on the surface, comprising the following steps: S1, using 3-aminopropyl triethoxysilane solution to carry out amino acid treatment on medical stone chemical treatment to prepare aminoated medical stone; S2, use glutaraldehyde solution to carry out aldehyde modification on the aminoated medical stone prepared in step S1, and prepare aldehydeated medical stone; S3, use step S2 The prepared aldylated medical stone is placed in ε-polylysine solution for Schiff alkalization reaction, and the medical stone loaded with ε-polylysine in the form of Schiff base is prepared; S4, step S3 The prepared medical stone loaded with ε-polylysine is placed in a sodium borohydride solution for reduction reaction to reduce the Schiff base, and the medical stone loaded with ε-polylysine stably is prepared. The ε-polylysine loaded by the method provided by the invention has stable and reliable antibacterial properties, has great application prospects and good economic and social benefits.

Description

technical field [0001] The invention relates to the technical field of medical stone materials, in particular to a preparation method of medical stone with ε-polylysine antibacterial coating on its surface. Background technique [0002] Medical stone is a natural silicate mineral, which is non-toxic and harmless to organisms and has certain biological activity. The main chemical composition of medical stone is inorganic aluminosilicate, and it also has a special porous sponge-like structure, which has strong adsorption force and water purification effect, and is widely used in water purification and other fields. [0003] However, there is an obvious problem in using medical stone to purify water, which is the secondary pollution of water quality. Because in the process of medical stone treatment of water, the microorganisms adsorbed by the medical stone can multiply rapidly on the surface of the medical stone, thus covering the surface of the medical stone. On the one hand...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C02F1/50C02F1/28B01J20/26B01J20/30
CPCB01J20/12B01J20/262C02F1/281C02F1/285C02F1/50
Inventor 阳文静游清徽蔡险峰徐贤柱王曼莹
Owner JIANGXI NORMAL UNIV
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