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Application of EPO in preparation of hepatocellular carcinoma TACE curative effect evaluation reagent

A technique for hepatocellular carcinoma and efficacy evaluation, applied in the field of biomedicine

Active Publication Date: 2020-05-19
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The relationship between EPO and TACE in liver cancer has not been reported

Method used

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  • Application of EPO in preparation of hepatocellular carcinoma TACE curative effect evaluation reagent
  • Application of EPO in preparation of hepatocellular carcinoma TACE curative effect evaluation reagent

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Embodiment Construction

[0016] The applicant's research found that the expression level of EPO in patient samples is directly correlated with the prognosis of TACE. If the level of EPO is high, the patient is not suitable for conventional TACE treatment; if the level of EPO is low, the prognosis of the patient is good with conventional TACE. Therefore, the present invention establishes a new TACE curative effect prediction system.

[0017] Hepatocellular carcinoma TACE curative effect evaluation reagents include EPO monoclonal antibody or polyclonal antibody, solid phase carrier coated with antibody and detection antibody capable of binding detectable signal molecules. A specific method can be as follows: add patient serum or plasma samples to the solid phase carrier coated with EPO monoclonal antibody or polyclonal antibody, after incubation, add biotinylated detection antibody (binding EPO), after incubation and washing, then Add horseradish peroxidase-labeled avidin, add TMB substrate to develop ...

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Abstract

The invention discloses the application of EPO in the preparation of a hepatocellular carcinoma TACE curative effect evaluation reagent, provides the hepatocellular carcinoma TACE curative effect evaluation reagent, and is characterized in that the reagent is used for quantitatively detecting the expression level of EPO protein. The invention discloses that the level of Erythropoietin (EPO) in peripheral blood of a hepatocellular carcinoma patient can well judge the prognosis of TACE of hepatocellular carcinoma for the first time.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to the application of EPO in the preparation of a TACE curative effect evaluation reagent for hepatocellular carcinoma and provides a TACE curative effect evaluation reagent for hepatocellular carcinoma. Background technique [0002] Liver cancer is one of the most common clinical malignant tumors, and its mortality rate ranks second among malignant tumors. Transcatheter Arterial Chemoembolization (TACE) is one of the main methods for clinical hepatocellular carcinoma surgical resection to prevent recurrence, and is also one of the main non-surgical treatment methods for advanced hepatocellular carcinoma. For applicable patients, it can achieve tumor control The effect of development and prolongation of lifespan. However, the clinical efficacy of TACE is related to many factors, such as tumor clinical stage, pathological type, liver function status, serum AFP level, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/577
CPCG01N33/577G01N33/68G01N2333/505G01N2800/52
Inventor 姬峻芳位熙旸
Owner ZHEJIANG UNIV