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Cepharanthine-containing anti-inflammation medicine composition and preparation method thereof

A technology of stephine and anti-inflammatory drugs, applied in the field of medicine, can solve the problems of stephine's application field limitations, undeveloped applications, and irritating reactions, so as to improve the anti-inflammatory effect, have a significant anti-inflammatory effect, and reduce the irritating effect Effect

Inactive Publication Date: 2020-06-05
GUANGZHOU JINAN BIOMEDICINE RES & DEV CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this patent uses stephine in the culture medium, and does not develop its application in other fields
[0007] In summary, the application of stephanine in the prior art is relatively limited, and anti-inflammatory drugs are likely to cause irritation

Method used

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  • Cepharanthine-containing anti-inflammation medicine composition and preparation method thereof
  • Cepharanthine-containing anti-inflammation medicine composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The extract of Radix japonicus can be purchased from Xi'an Qiancao Biotechnology Co., Ltd.; the extract of Andrographis paniculata can be purchased from Hubei Longfei Biotechnology Co., Ltd.; the essential oil can be purchased from Dongguan Jinglu Trading Co., Ltd. Embodiment 1 A kind of anti-inflammatory pharmaceutical composition containing stephanine

[0031] The anti-inflammatory pharmaceutical composition containing stephanine comprises the following components and their percentages by weight: 1% of Radix japonicus extract, 1% of Andrographis paniculata extract, 2% of stephine, 1% of glucose, and 0.2% of essential oil , emulsifier 0.1%, purified water 94.7%; the stephenine is extracted from the ground root, the specific process is: take the ground root, dry, pulverize, pass through a 100 mesh sieve, and use a 2% hydrochloric acid aqueous solution Cold soaking extraction, the extract is alkalized by NaOH, precipitated, the pH value is 9, the precipitate is filtered,...

Embodiment 2

[0036] Embodiment 2 A kind of anti-inflammatory pharmaceutical composition containing stephanine

[0037] The anti-inflammatory pharmaceutical composition containing stephanine comprises the following components and their percentages by weight: 2% of Radix japonicus extract, 2% of Andrographis paniculata extract, 3% of stephine, 3% of glucose, and 0.4% of essential oil , 0.3% emulsifier, 89.3% purified water; the preparation process of stephine is similar to that of Example 1; the emulsifier is composed of soybean protein and lecithin in a weight ratio of 5:13.

[0038] The preparation method of the anti-inflammatory pharmaceutical composition containing stephanine, comprises the steps:

[0039] S1. Take purified water with an additive amount of 50%, heat it to 50° C., add the extracts of Radix Orbis Radix and Andrographis paniculata, stir at 600 rpm for 30 minutes, and mix well to obtain mixture I;

[0040] S2. Cool the mixture I obtained in step S1 to 30° C., add stephanine...

Embodiment 3

[0042] Embodiment 3 A kind of anti-inflammatory pharmaceutical composition containing stephanine

[0043] The anti-inflammatory drug composition containing stephanine is composed of the following components and their weight percentages: 1.5% of Radix ordonis extract, 1.5% of Andrographis paniculata extract, 2.5% of stephanine, 2% of glucose, and 0.3% of essential oil %, emulsifier 0.2%, purified water 92%; the preparation process of stephine is similar to Example 1; the emulsifier is composed of soy protein and lecithin in a weight ratio of 4:11.

[0044] The preparation method of the anti-inflammatory pharmaceutical composition containing stephanine, comprises the steps:

[0045] S1. Take purified water with an additive amount of 50%, heat it to 45° C., add the extract of Oryx radix L. and Andrographis paniculata, stir at 550 rpm for 25 minutes, and mix well to obtain mixture I;

[0046] S2. Cool the mixture I obtained in step S1 to 25° C., add stephanine and glucose, stir at ...

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Abstract

The invention belongs to the field of medicines and in particular relates to a cepharanthine-containing anti-inflammation medicine composition and a preparation method thereof. The anti-inflammation medicine composition provided by the invention comprises the following components in percentage by weight: 1-2% of a herba rabdosiae extract, 1-2% of a common andrographis herb extract, 2-3% of cepharanthine, 0.2-0.4% of essence oil, 0.1-0.3% of an emulsifier and 92.3-95.7% of purified water. Since an isoquinoline alkaloid compound, namely the cepharanthine extracted from delavay stephania roots, is added into the anti-inflammation medicine composition provided by the invention, the anti-inflammation performance of a medicine can be improved, no stimulation reaction can be caused for human bodies, and probability is provided for developing a type of novel anti-inflammation medicines.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an anti-inflammatory pharmaceutical composition containing stephanine and a preparation method thereof. Background technique [0002] Inflammation is a defense measure of the body to external stimuli, manifested as redness, swelling, heat, pain and dysfunction. Inflammation is with us all the time, partly because of wounds and infections, and partly because of the physical pain and damage it causes. [0003] Inflammation beyond the norm may exacerbate the development of various diseases, such as rheumatoid arthritis, Crohn's disease, atherosclerosis, sepsis and tumors, all of which have a considerable relationship with inflammation. The specific manifestations are the increase of pro-inflammatory factors and the expression of co-stimulatory molecules. [0004] In today's society, more and more natural plant-based products have been used as the basis of human medicines. Alth...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61K31/4741A61K47/44A61P29/00
CPCA61K31/4741A61K36/19A61K36/53A61K47/44A61P29/00A61K2300/00
Inventor 王一飞王瑶刘宇坤
Owner GUANGZHOU JINAN BIOMEDICINE RES & DEV CENT
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