Application of melatonin combined with methylcobalamin in the treatment of diabetic wound healing disorder

A wound healing and methylcobalamin technology, applied in the field of biomedicine to achieve the effect of healing promotion

Active Publication Date: 2021-03-26
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the inventor found that Mecobala has not been reported in the treatment of diabetic skin

Method used

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  • Application of melatonin combined with methylcobalamin in the treatment of diabetic wound healing disorder
  • Application of melatonin combined with methylcobalamin in the treatment of diabetic wound healing disorder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] 1 Materials and methods

[0054] 1.1 Experimental animals

[0055] Twenty-four male SD rats (weight: 220±20g) aged about 8 weeks were purchased from the Experimental Animal Center of Shandong University, and the experimental protocol has been approved by the Animal Experiment Ethics Committee of Shandong University School of Medicine (No. Authorization, experiments were strictly in accordance with the "Guidelines for Animal Care and Treatment" (Eighth Edition, 2011).

[0056] 1.2 Experimental materials and reagents

[0057] Melatonin (M5250-1G; Sigma-Aldrich, St. Louis, MO, USA); Mecobalt (Shanghai Aibison Biotechnology Co., Ltd.).

[0058] 1.3 Preparation of SD rat diabetic model and diabetic wound model

[0059] All animals were fasted without food and water for 12 hours before modeling, and blood was collected at the end of the next morning to measure fasting blood glucose. Subsequent intraperitoneal (i.p.) injections of streptozotocin (STZ; 75 mg / kg; Sigma-Aldri...

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Abstract

The invention provides an application of melatonin and mecobalamin in treatment of diabetic wound healing disorders, and belongs to the technical field of biological medicine. Research of the invention shows that the combined use of the melatonin and the mecobalamin can significantly promote healing of wound surfaces of diabetic rats, and the effect of the combined medication is better than that of the melatonin when used alone; the combined medication significantly promotes the healing of diabetic skin wounds by reducing inflammatory response at the wound part and increasing the number of epidermal stem cells; and a current status of diabetic wound treatment (difficult to heal and high costs of treatment) and the advantages of price and application safety of small molecule drugs such as the melatonin and the mecobalamin are combined, the research of the mixed preparation of the melatonin and the mecobalamin has important clinical practical value, and the research results of the invention provide a theoretical basis and novel treatment ideas for clinical application.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of melatonin combined with mecobalamin in treating diabetic wound healing disorder. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Diabetes is a chronic metabolic disease that seriously endangers human health and quality of life. Research shows that the number of people with diabetes in the world was 415 million in 2015 and may reach 642 million by 2040. Complications caused by diabetes are the main cause of disability and death of diabetic patients. Delayed or non-healing ulcer wound healing is the primary factor for patients to be hospitaliz...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/714A61K31/4045A61P3/10A61P29/00A61P17/02
CPCA61K31/4045A61K31/714A61P3/10A61P17/02A61P29/00A61K2300/00
Inventor 郝爱军姬光瑜周文娟李羡
Owner SHANDONG UNIV
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