Application of melatonin combined with methylcobalamin in the treatment of diabetic wound healing disorder
A wound healing and methylcobalamin technology, applied in the field of biomedicine to achieve the effect of healing promotion
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[0053] 1 Materials and methods
[0054] 1.1 Experimental animals
[0055] Twenty-four male SD rats (weight: 220±20g) aged about 8 weeks were purchased from the Experimental Animal Center of Shandong University, and the experimental protocol has been approved by the Animal Experiment Ethics Committee of Shandong University School of Medicine (No. Authorization, experiments were strictly in accordance with the "Guidelines for Animal Care and Treatment" (Eighth Edition, 2011).
[0056] 1.2 Experimental materials and reagents
[0057] Melatonin (M5250-1G; Sigma-Aldrich, St. Louis, MO, USA); Mecobalt (Shanghai Aibison Biotechnology Co., Ltd.).
[0058] 1.3 Preparation of SD rat diabetic model and diabetic wound model
[0059] All animals were fasted without food and water for 12 hours before modeling, and blood was collected at the end of the next morning to measure fasting blood glucose. Subsequent intraperitoneal (i.p.) injections of streptozotocin (STZ; 75 mg / kg; Sigma-Aldri...
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