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Application of zanthoxylum nitidum extract in preparation of medicine for preventing and treating spinal fusion surgery inflammation

A technology of double-sided needles and extracts, applied in the direction of drug combinations, antipyretics, anti-inflammatory agents, etc., can solve the problem of uncontrollable exudation of inflammatory substances, and achieve the effect of reducing high expression and high permeability

Inactive Publication Date: 2020-06-12
SHANGHAI EAST HOSPITAL EAST HOSPITAL TONGJI UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no literature reporting that limpet can be used to prevent and treat inflammation around spinal fusion surgery caused by BMP-2
Simply resisting the inflammatory response without increasing the permeability between cells can not control the exudation of inflammatory substances, and it will still cause postoperative inflammatory response

Method used

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  • Application of zanthoxylum nitidum extract in preparation of medicine for preventing and treating spinal fusion surgery inflammation
  • Application of zanthoxylum nitidum extract in preparation of medicine for preventing and treating spinal fusion surgery inflammation
  • Application of zanthoxylum nitidum extract in preparation of medicine for preventing and treating spinal fusion surgery inflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] This example involves the specific implementation process and efficacy verification of the prevention and treatment of BMP-2-induced inflammation around spinal fusion surgery with LMZ extract:

[0031] 1. Cell culture

[0032] Human umbilical vein endothelial cells (HUVECs) were purchased from the American Type Culture Collection. In high glucose endothelial cell culture medium (Dulbecco's Modified Eagle Medium, Sigma, 211-500) containing 10% fetal bovine serum, 1% penicillin and 1% streptomycin, 37°C, 5% CO 2 cultured in a wet cell incubator. When the whole cell fusion rate reaches about 80%, the drug treatment is carried out.

[0033] 2. Drug handling

[0034] Modeling: RhBMP-2 with a concentration gradient of 0, 10 and 20ng / ml acted on human umbilical vein endothelial cells for 8 hours.

[0035] Intervention with LMZ extract + modeling: 4 hours before 20ng / ml rhBMP-2 intervention, 3 doses of LMZ extract (extractable or commercially available, this example The ex...

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Abstract

The invention discloses an application of a zanthoxylum nitidum extract in preparation of a medicine for preventing and treating spinal fusion surgery inflammation. It is found that zanthoxylum nitidum can inhibit high expression of inflammatory pathways caused by BMP-2, so that generation of cellular inflammatory substances is reduced, and tight junction protein expression is increased. The spinal fusion surgery peripheral inflammatory response caused by the BMP-2 is solved from the cellular mechanism level, the side effects existing in the existing drug research are overcome, and a basis isprovided for optimizing the clinical application of the BMP-2.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to the application of an extract of liangmianzhen in the preparation of a medicine for preventing and treating inflammation in spinal fusion surgery; in particular, it relates to the use of an extract of liangmianzhen in preparing a medicine for preventing and treating inflammation around spinal fusion surgery caused by BMP-2 in the application. Background technique [0002] Bone morphogenetic protein-2 (BMP-2), as an effective osteoinductive cytokine, is widely used clinically to promote osteogenesis. In 2002, FDA approved recombinant human bone morphogenic protein-2 (rhBMP-2) for anterior lumbar fusion. This technology has brought a leap forward in spinal fusion surgery, and the 100% spinal fusion rate is significantly higher than other traditional osteogenic materials. However, follow-up showed that BMP-2 could lead to inflammation-related complications, incl...

Claims

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Application Information

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IPC IPC(8): A61K36/758A61K31/4741A61P29/00
CPCA61K31/4741A61K36/758A61P29/00
Inventor 胡韬陈疾忤罗智文孙亚英王善金吴德升
Owner SHANGHAI EAST HOSPITAL EAST HOSPITAL TONGJI UNIV SCHOOL OF MEDICINE
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