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Use of jasurolignoside in the preparation of medicines for treating and/or preventing lung injury

A technology for acute lung injury and uses, applied in the field of medicine, can solve problems such as effective lung injury

Active Publication Date: 2021-04-13
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No studies have shown that Jasurolignoside is effective in the treatment of lung injury

Method used

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  • Use of jasurolignoside in the preparation of medicines for treating and/or preventing lung injury
  • Use of jasurolignoside in the preparation of medicines for treating and/or preventing lung injury
  • Use of jasurolignoside in the preparation of medicines for treating and/or preventing lung injury

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Embodiment Construction

[0029] The present invention will be further described in detail below in conjunction with the accompanying drawings, so that those skilled in the art can implement it with reference to the description.

[0030] It should be understood that terms such as "having", "comprising" and "including" as used herein do not entail the presence or addition of one or more other elements or combinations thereof.

[0031] It should be noted that the experimental methods described in the following embodiments, unless otherwise specified, are conventional methods, and the reagents and materials, unless otherwise specified, can be obtained from commercial sources.

[0032] 1. Materials

[0033] 1.1 Experimental animals

[0034] SPF grade healthy BALB / C mice, weighing 20-22g, 7-8 weeks old, male, were purchased from Hunan Slack Jingda Experimental Animal Co., Ltd. All experimental animals were raised in a controlled environment, room temperature 18-24°C, The humidity was 40%-50%. During the e...

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Abstract

The invention discloses the use of Jasurolignoside in the preparation of medicines for treating and / or preventing lung injury in mammals including humans. The structural formula of Jasurolignoside is formula (I): the invention has a certain protective effect on lung injury and inhibits lung inflammation Sexual cytokine release and inhibition of TLR4 signaling pathway.

Description

technical field [0001] The invention relates to the technical field of medicine. More specifically, the present invention relates to the use of Jasurolignoside in the preparation of medicines for treating and / or preventing lung injury. Background technique [0002] In recent years, the morbidity and mortality of pneumonia have been increasing. At present, the commonly used drugs for the treatment of pneumonia include hormones and the following types of antibiotics: the first type is penicillins and first-generation cephalosporins, etc.; the second type is fluoroquinolones (moxifloxacin, gemifloxacin, and levofloxacin); The third category is macrolide drugs (erythromycin and azithromycin, etc.). In recent years, despite the application of powerful antibiotics and effective vaccines, the mortality rate of pneumonia has not decreased, but has increased. The reason is that the extensive use of antibiotics leads to the increase of multi-drug resistant pathogens, which leads to...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P11/00A61P31/00
CPCA61K31/7048A61P11/00A61P31/00
Inventor 高红伟韩珊苑仁祎坤黄莉婷许琼明
Owner GUANGXI UNIV OF CHINESE MEDICINE
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