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Application of gerbera piloselloides and gerbera piloselloides extract in preparation of medicine for preventing and/or treating asthma

The technology of Gerbera gerbera and its extract, applied in the field of medicine, can solve the problems of anti-bronchial asthma curative effect and unreported active parts, and achieve the effects of safety, no toxic and side effects, alleviation of damage and improvement of asthma symptoms.

Inactive Publication Date: 2020-07-31
GUIZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern pharmacological studies have shown that gerbera has the effects of relieving cough, reducing phlegm and relieving asthma, and its curative effect is definite. It has a good application prospect in the field of medicine, but its anti-bronchial asthma effect and active parts have not been reported.

Method used

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  • Application of gerbera piloselloides and gerbera piloselloides extract in preparation of medicine for preventing and/or treating asthma
  • Application of gerbera piloselloides and gerbera piloselloides extract in preparation of medicine for preventing and/or treating asthma
  • Application of gerbera piloselloides and gerbera piloselloides extract in preparation of medicine for preventing and/or treating asthma

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Embodiment Construction

[0028] The technical solutions of the present invention will be further explained below in conjunction with specific embodiments, but the scope of protection is not limited to the descriptions made.

[0029] Experiment 1 Screening of Potential Anti-Asthma Active Parts of Gerbera officinalis

[0030] 1 material

[0031] 1.1 Animals

[0032]Healthy female Kunming mice (20±2g) were purchased from Changsha Tianqin Biotechnology Co., Ltd., which are SPF animals, and the experimental animal production license number is SCXK (Xiang) 2014-0011. The experimental animals were kept in an environment of 12h light / dark cycle, 18-25° C., and relative humidity of 50-70% for one week, and then used for experimental research, during which they had free access to food and water. All experimental protocol studies were approved by the Animal Ethics Committee of Guizhou Medical University.

[0033] 1.2 Instruments and reagents

[0034] Ovalbumin (OVA, sigma), aluminum hydroxide adjuvant (therm...

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Abstract

The invention relates to the technical field of medicines, and in particular relates to an application of gerbera piloselloides and a gerbera piloselloides extract in preparation of medicines for preventing and / or treating asthma. Research finds that the gerbera piloselloides and the gerbera piloselloides extract, especially a 60% ethanol extraction part of gerbera piloselloides, can play an anti-asthma role by inhibiting IgE generation in serum and inhibiting the levels of IL-8, IL-5, TNF-alpha and other inflammatory factors, and have obvious anti-asthma activity, which indicates that the 60%ethanol extraction part of gerbera piloselloides after elution and purification with 10% ethanol can be used as an anti-asthma effective active part of gerbera piloselloides. The gerbera piloselloides and the gerbera piloselloides extract can obviously improve asthma symptoms, can improve allergic reaction symptoms; moreover, and relieving the damage degree of lung tissues, and can be used to prepare medicines for preventing or treating asthma. In addition, the gerbera piloselloides is a natural Chinese herbal medicine, is safe and is free of toxic and side effects when being used, and has agood application prospect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of gerbera gerbera and its extract in the preparation of drugs for preventing and / or treating asthma. Background technique [0002] Bronchial asthma is a common chronic airway non-specific inflammatory respiratory disease involving various cells, such as eosinophils, mast cells, lymphocytes, airway epithelial cells and other cell components. Common predisposing factors for asthma include respiratory infection, inhalation of allergens, occupational factors, and air pollution. In the past 30 years, the morbidity and mortality of asthma patients have increased significantly around the world. The number of asthma patients worldwide has reached 300 million, especially in developed countries. In China, nearly 30 million patients suffer from bronchial asthma, which has become a global It is one of the countries with the highest mortality rate of asthma. It can be seen ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P11/06A61P37/08
CPCA61K36/28A61P11/06A61P37/08A61K2236/333A61K2236/55
Inventor 刘春花潘洁陆苑孙佳刘亭李勇军马雪兰燕宇王永林王爱民
Owner GUIZHOU MEDICAL UNIV
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