3 results about "Anti asthmatic" patented technology

The present application relates to a kind of quercetin and ketotifen co-assembly nanomedicine and its construction method and application, belong to nanomedicine technical field;The construction method includes the following steps: S1, quercetin and ketotifen are dissolved in organic solvent, and mixed uniformly;S2, remove organic solvent, so that quercetin and ketotifen co-assembly occurs, and forms co-assembly solid;S3, to co-assembly solid is added dispersion medium and is hydrated, and is treated by ultrasonic dispersion, and the dispersion liquid of quercetin and ketotifen co-assembly nanomedicine is obtained.The present application is creatively constructed as co-assembly nanomedicine without any exogenous carrier, not only simultaneously solves the technical problems of poor water-solubility of quercetin and obvious central inhibition side effects of ketotifen, but also realizes the treatment goal of high efficiency, low toxicity, synergistic anti-asthma, with significant clinical conversion prospect and industrial application value.

The application discloses a new water-soluble phenolic acid salviamarinic acid B extracted from radix salviae miltiorrhizae, adopts a C48 / 80 induced RBL-2H3 cell degranulation in vitro model to simulate the degranulation phenomenon of mast cells in vitro, and first separates and identifies a new water-soluble phenolic acid compound (salviamarinic acid B) from the ethyl acetate part of radix salviae miltiorrhizae, which can inhibit the release of beta-Hex, reduce the levels of mMCP-1, beta-MCT, HIS and LTC4, significantly improve the degranulation phenomenon of RBL-2H3 cells, has significant anti-asthma activity, and has significant social and economic benefits.

The invention belongs to the field of medicinal plant development, and particularly relates to an anti-asthma inflammation traditional Chinese medicine extract as well as an extraction method and application thereof. Millettia specisoa champ is used as a raw material, and Millettia specisoa champ total flavonoids and Millettia specisoa champ total The two extracts are subjected to pharmacological experiments, and researches show that the beautiful millettia root extract containing the total flavonoids or the total polysaccharides can remarkably reduce the levels of Th2 inflammatory factors such as IL-4, IL-5, IL-9, IL-13 and GATA-3 in lung tissues, improve the levels of Th1 anti-inflammatory factors such as IFN-gamma, IL-12 and IL-27, regulate the proportion balance of Th1 / Th2 and inhibit airway inflammatory response; in addition, GATA-3 expression can be blocked, Th2 cell activation hyperfunction is inhibited, pathological characteristic change of asthma is relieved, and great development and utilization potential in asthma treatment is achieved.