Drug for treating cerebral apoplexy and construction method of endogenous stem cell expression animal model

A technology for constructing methods and animal models, applied in the field of medicine, can solve problems such as poor evidence-based effects, and achieve the effects of promoting proliferation, inhibiting excessive proliferation, and improving neurological function.

Inactive Publication Date: 2020-08-04
湖南省中医药研究院
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Problems solved by technology

[0003] Through the above analysis, the existing problems and defects of the prior art are: in the analysis of the influence of the prior art on the proliferation and differentiat

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  • Drug for treating cerebral apoplexy and construction method of endogenous stem cell expression animal model
  • Drug for treating cerebral apoplexy and construction method of endogenous stem cell expression animal model
  • Drug for treating cerebral apoplexy and construction method of endogenous stem cell expression animal model

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Embodiment Construction

[0029] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0030] Aiming at the problems existing in the prior art, the present invention provides a method for the application of Rougan Tongluo Decoction and the construction of an animal model of endogenous stem cell expression. The present invention will be described in detail below with reference to the accompanying drawings.

[0031] The invention provides a medicine for treating cerebral apoplexy, which is Rougan Tongluo decoction, and the medicine for treating cerebral apoplexy is prepared by using Rougan Tongluo decoction.

[0032]The Rougan Tongluo Decoction is composed of Radix Polygoni Multiflori 15g, Mulberry 15g, Lycium ...

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Abstract

The invention belongs to the technical field of medicine and pharmacology, and discloses a drug for treating cerebral apoplexy and a construction method of an endogenous stem cell expression animal model, and the drug for treating cerebral apoplexy is liver-softening collateral-dredging decoction. The number of rat brain tissue BrdU, BrdU/NeuN and BrdU/GFAP positive cells in each group at each time point is detected through an ischemia reperfusion model caused by middle cerebral artery occlusion, and the influence of the liver softening and collateral dredging soup on proliferation and differentiation of endogenous neural stem cells of rats with ischemic brain injury is analyzed. According to the method, an improved Longa method is adopted to manufacture an ischemia-reperfusion brain injury model caused by MCAO type middle cerebral artery occlusion of rats; it is verified that the liver-softening collateral-dredging decoction promotes proliferation of endogenous neural stem cells of ischemia-reperfusion brain injury rats, differentiates the endogenous neural stem cells into mature neurons, inhibits excessive proliferation of astrocytes, promotes nerve regeneration and repair and improves nerve functions.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a drug for treating cerebral apoplexy and a method for constructing an animal model expressing endogenous stem cells. Background technique [0002] At present, cerebrovascular disease is one of the three major diseases leading to the death of the global population, seriously endangering the daily activities of middle-aged and elderly people, and its high treatment and rehabilitation costs bring a heavy burden to families and society. Among them, ischemic cerebrovascular disease (ICD) accounts for about 60% to 80% of all cerebrovascular diseases. After ischemic stroke, the blood supply of brain tissue is hindered, and neurons become inflammatory, edema, denatured and even necrotic due to ischemia and hypoxia, which eventually leads to damage or even loss of information transmission function and integration function in the central nervous system. Endogenous neural ste...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61P9/10A01K67/02A61K35/62
CPCA01K67/02A01K2207/20A01K2227/105A01K2267/0375A61K35/62A61K36/232A61K36/488A61K36/537A61K36/605A61K36/65A61K36/704A61K36/71A61K36/734A61K36/815A61P9/10A61K2300/00
Inventor 龙华君李映晨刘雨周慎伍大华
Owner 湖南省中医药研究院
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