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Synthesis method and application of lead compound of pyranidene malononitrile photosensitizer

A technology for pyranylidene malononitriles and lead compounds, which is applied in the field of biomedicine, can solve the problems of high preparation cost, high cost and the like, and achieves the effect of treating cancer

Active Publication Date: 2022-07-05
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these photosensitizers are mostly mixtures (mixing of different isomers), and the preparation cost is high, and the problems such as expensive

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  • Synthesis method and application of lead compound of pyranidene malononitrile photosensitizer
  • Synthesis method and application of lead compound of pyranidene malononitrile photosensitizer
  • Synthesis method and application of lead compound of pyranidene malononitrile photosensitizer

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Embodiment Construction

[0038] The content of the present invention will be described in detail below with reference to specific embodiments. It should be noted that the following description is intended to illustrate rather than limit the present invention.

[0039] Pyranylidene malononitrile-based photosensitizer lead compound, the compound has the following general formula:

[0040]

[0041] where R=H is PS1; or for PS2;

[0042] or for PS3.

[0043] 1. Synthesis of three pyranidene malononitrile-based photosensitizer lead compounds of the present invention. Described PS1 synthesis method, comprises the steps:

[0044] Weigh 0.17 g (1 mmoL) of 2,6-dimethyl-4-pyranylidene malononitrile and 0.21 g (2 mmoL) of benzaldehyde and dissolve them in 10 mL of freshly steamed acetonitrile, and then add 2-3 drops of piperidine dropwise. , under the protection of argon, the reaction was stirred at 76°C for 24h. After the reaction of the substrate was completed, it was cooled to room temperature. The...

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Abstract

Synthesis method of lead compound of pyrylanidene malononitrile type photosensitizer and application thereof Small molecule photosensitizer (PS1-3), the structure is shown in formula (I), and its photodynamic properties and fluorescence properties are different. The invention also discloses the application of tumor imaging and treatment at the cell level. The lead compound in the present invention has the characteristics of simple structure, small molecular weight, definite chemical structure, easy preparation, purification and further modification, and low cytotoxicity. Cell experiments have shown that near-infrared imaging and photodynamic therapy of cells can be achieved with the help of an external visible light source, which significantly inhibits tumor growth. Therefore, the single-molecule photosensitizer lead compound involved in the present invention has a good application prospect in breast cancer treatment.

Description

technical field [0001] The invention relates to a method for synthesizing a pyranidene malononitrile-type photosensitizer lead compound and application thereof, and belongs to the field of biomedicine. Background technique [0002] With an aging population and changing lifestyles, the incidence of cancer in China continues to rise. The latest data show that the number of new cancer patients and deaths in my country have reached 4.3 million and 2.8 million, respectively. Although the advancement of science and technology has led to the rapid improvement and improvement of medical technology, the treatment of cancer, a major global disease, is still a major problem for human beings in medical technology, which needs to be solved and further developed. Clinically, the commonly used cancer treatment methods mainly include surgery, chemotherapy, and radiotherapy. Recently, some emerging therapies have been developed, such as photodynamic therapy, photothermal therapy, gene ther...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D309/34A61K41/00A61P35/00
CPCC07D309/34A61K41/0057A61P35/00Y02A50/30
Inventor 高杰袁泽利屈小芳
Owner ZUNYI MEDICAL UNIVERSITY