A Method for Estimating Regional Population Based on the Concentration of 4-Pyridoxic Acid in Wastewater
A technology of population and pyridoxine, which is applied in the field of population estimation, can solve problems such as easy deviation of population estimation results and affect the accuracy of estimation results, and achieve the effects of stable human excretion rate, elimination of population changes, and difficult adsorption
Active Publication Date: 2022-02-11
CHINA PHARM UNIV
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However, due to many reasons such as the concentration of human endogenous substances and environmental factors in sewage, most human endogenous substances cannot exist stably in sewage, which seriously affects the accuracy of the estimation results. Therefore, it is urgent to determine a suitable human endogenous substance. Sexual substances as biomarkers and improving their detection methods to improve the accuracy of population estimation
[0004] At present, when conducting sewage epidemiological research at home and abroad, the human metabolite cotinine of tobacco is often used as a biomarker to estimate the regional population. However, in the cotinine method, the calculation process of cotinine per capita production involves per capita Parameters such as the number of cigarettes smoked per day, the content of nicotine in tobacco, the intake of nicotine by the human body, the rate of metabolism of nicotine after inhalation into the human body, and other parameters are mostly determined by estimation, which makes the population estimation results prone to deviation
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[0089] The present invention is based on the 4-pyloxic acid concentration in the sewage sample measured by solid phase extraction - UPLC-MS / MS method, and is carried out in 10 sewage treatment plants as an example. evaluate. Compared with the data obtained by the population census, more accurate and real-time, can reduce the deviation caused by population flow on the results of the epidemiological experiments of sewage.
[0090] The specific implementation method of the present invention is as follows:
[0091] (1) Preparation of sewage samples
[0092] Automatic sampler collects 10 sewage treatment plants in Hebei Province 24-hour mixed sewage samples, and the mass percentage of 36% concentrated hydrochloric acid is adj to 2, quantified 50ml, precisely add 100 ng / ml deuterated internal standard 4 - Pyridic acid-D 3 100 μL, using GE Whatman non-adhesive glass fiber filter paper GF / C TM filter. Samples that cannot be processed in time are stored in the -20 ° C refrigerator, a...
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Abstract
The invention relates to a method for assessing regional population based on the concentration of 4-pyridoxic acid in sewage, and belongs to the field of assessing the population of the assessed area in environmental monitoring sewage epidemiology. After the sewage samples were separated and enriched by solid-phase extraction, the concentration of 4-pyridoxic acid in the sewage was determined by using ultra-high performance liquid chromatography-mass spectrometry as a detection tool. The discharge rate and other parameters can be used to estimate the real-time population of the assessed area. The present invention establishes a method for assessing regional population based on the concentration of 4-pyridoxic acid in sewage, which can eliminate regional population changes caused by population flow and other reasons, thereby obtaining more accurate population data and making the environment based on sewage epidemiology Monitoring and research results are more accurate and reliable.
Description
Technical field [0001] The present invention belongs to an important part of the environmental monitoring of sewage epidemiological studies - the area of the population of the region to be evaluated. Specifically, a method of evaluating the number of population of the region based on endogenous biomarker 4-pyridic acid concentration in sewage. Background technique [0002] Popular sewage epidemiology is based on the content of endogenous substances, drugs, hobbies, drugs and their metabolites in a certain area. By refunding data such as the concentration of the target compound, the total load amount, and the per capita load amount, thus The situation reflected in a certain region or time period target compound is, the method of monitoring and evaluating the prevalence of drug abuse, drug abuse, drugs involved in drugs, and hobby consumption, etc. Environmental monitoring institutions are widely used. Compared to traditional epidemiological surveys, such as questionnaire survey,...
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IPC IPC(8): G01N30/02G01N30/06G01N30/34G01N30/86
CPCG01N30/02G01N30/06G01N30/34G01N30/8675G01N2030/045G01N2030/062
Inventor 狄斌侯臣之王婧媛
Owner CHINA PHARM UNIV
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