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Dihydromyricetin with hangover alleviating function

A technology for dihydromyricetin and hangover, applied in the field of medicine, can solve problems such as acute alcohol poisoning, drunkenness, endangering physical health, etc., and achieve the effects of preventing the rise of malondialdehyde, reducing the content, and preventing the depletion of glutathione

Pending Publication Date: 2020-08-07
SHANGHAI SPARK PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, excessive drinking can easily lead to drunkenness or acute alcoholism, which is extremely harmful to health.

Method used

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  • Dihydromyricetin with hangover alleviating function
  • Dihydromyricetin with hangover alleviating function
  • Dihydromyricetin with hangover alleviating function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: safety test

[0016] 1. Purpose of the test

[0017] Observation of the Acute Toxic Effect of Dihydromyricetin on ICR Mice

[0018] 2. Information about reagents and materials

[0019] Test substance: Dihydromyricetin

[0020] Storage conditions of the test substance: 4°C, dry and protected from light

[0021] Other reagents: sterile water for injection

[0022] Source: Guangdong Aixide Pharmaceutical Co., Ltd.

[0023] Properties: colorless transparent liquid

[0024] Specification: 500ml / bottle

[0025] Storage conditions: RT

[0026] 3. Drug preparation

[0027] Solvent: sterile water for injection

[0028] Preparation of the test substance: Weigh the required mass of the test substance, add sterile water for injection to prepare to the required concentration, and mix well before administration.

[0029] 4. Experimental Animal Feeding

[0030] Animal breed and strain: ICR mice

[0031] Level: SPF level

[0032] Gender: half male and half ma...

Embodiment 2

[0059] Embodiment 2: effectiveness test

[0060] 1. Purpose of the test

[0061] To verify whether dihydromyricetin can effectively hangover

[0062] 2. Information about reagents and materials

[0063] Test substance: Dihydromyricetin

[0064] Storage conditions of the test substance: 4°C, dry and protected from light

[0065] Other reagents:

[0066] 1) Sterile water for injection

[0067] Source: Guangdong Aixide Pharmaceutical Co., Ltd.

[0068] Properties: colorless transparent liquid

[0069] Specification: 500ml / bottle

[0070] Storage conditions: RT

[0071] 2) Wine

[0072] Brand: Red Star Erguotou

[0073] Specification: 500ml / bottle

[0074] Storage conditions: RT

[0075] 3. Drug configuration

[0076] Solvent: sterile water for injection

[0077] Preparation of the test substance: Weigh the required mass of the test substance, add sterile water for injection to prepare to the required concentration, and mix well before administration

[0078] 4. Exp...

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PUM

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Abstract

The invention discloses a novel application of dihydromyricetin, namely an application of dihydromyricetin in preparation of food, health care products or medicines with a hangover alleviating effect.The dihydromyricetin has the advantages that the dihydromyricetin has a good hangover alleviating function, can be used for increasing the expression of hippocampus and neuronal GABAARs a4 subunits,has the effects of resisting alcoholism and alcohol dependence, can also effectively prevent liver reduced glutathione depletion and malondialdehyde increase caused by alcohol, reduces the content oftriglyceride, reduces the fatty degeneration degree of hepatocytes, and has good effects of preventing and treating alcoholic liver injury.

Description

technical field [0001] The present application relates to the technical field of medicine, in particular to a flavonoid compound with anti-alcoholic function, that is, dihydromyricetin. Background technique [0002] As a part of our country's social culture, drinking culture has already penetrated into the daily life of many people. Drinking alcohol in moderation can promote blood circulation, dispel dampness and relieve pain, and relax the mood. However, excessive drinking can easily lead to drunkenness or acute alcoholism, which is extremely harmful to health. Acute alcoholism caused by heavy drinking has become one of the diseases with the highest incidence during holidays. The development of safe and efficient hangover products has been paid more and more attention by the society. [0003] Dihydromyricetin, molecular formula: C 15 h 12 o 8 , relative molecular mass: 320.25, chemical structure: (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-4-one. Dihyd...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P39/02A61P25/32A61P1/16A61P3/06A23L33/105
CPCA61K31/352A61P39/02A61P25/32A61P1/16A61P3/06A23L33/105A23V2002/00A23V2200/30A23V2200/334A23V2200/3262A23V2250/2116A23L33/40
Inventor 宋昆元陈伟伟
Owner SHANGHAI SPARK PHARM CO LTD
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