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Composite nano microsphere with rapid mucus permeation effect as well as preparation method and application of composite nano microsphere

A technology of nano-microspheres and polymers, which is applied in the field of biomedical materials, can solve the problems that nanoparticles are difficult to penetrate effectively and reduce the therapeutic effect of drugs, so as to improve the mucus penetration ability, improve the therapeutic effect and reduce adverse side effects Effect

Active Publication Date: 2020-08-21
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mucus barrier in the human body, such as the high secretion of respiratory mucus in common respiratory diseases, makes it difficult for nanoparticles to penetrate effectively, reducing the therapeutic effect of drugs

Method used

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  • Composite nano microsphere with rapid mucus permeation effect as well as preparation method and application of composite nano microsphere
  • Composite nano microsphere with rapid mucus permeation effect as well as preparation method and application of composite nano microsphere
  • Composite nano microsphere with rapid mucus permeation effect as well as preparation method and application of composite nano microsphere

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preparation example Construction

[0061] A specific embodiment of the present invention also provides a method for preparing composite nano-microspheres, which comprises the following steps:

[0062] 1) The metal organic framework ZIF-8 is mixed with black phosphorus quantum dots and active components to obtain an aqueous solution of metal organic framework ZIF-8 loaded with black phosphorus quantum dots and active components;

[0063] 2) surface modification of the product obtained in step 1) with hydrophilic high molecular polymer to obtain composite nano-microspheres;

[0064] The hydrophilic high molecular polymer is selected from polyethylene glycol.

[0065] In some embodiments of the present invention, the method for surface modification in step 2) is as follows: adding a hydrophilic high molecular polymer to the aqueous solution obtained in step 1), mixing evenly, and centrifuging to remove excess hydrophilic high molecular polymer, That's it.

[0066] In some embodiments of the present invention, in...

Embodiment 1

[0086] Example 1 PEG-modified metal-organic framework ZIF-8 loaded with black phosphorus quantum dots and therapeutic drugs

[0087] This embodiment provides a composite nano-microsphere with metal-organic framework ZIF-8 as the main body of the nano-microsphere, the inner part of the composite nano-microsphere is wrapped with black phosphorus quantum dots and therapeutic drugs, and the external surface is modified with PEG. Its preparation method is:

[0088] (1) Grind the block black phosphorus with a particle size of 80 μm in a vacuum environment and disperse it in a mixed solvent of N-methylpyrrolidone and dimethylformamide, and mix the dispersion with a concentration of 2 mg / mL with N-methylpyrrolidone. pyrrolidone and sodium hydroxide were mixed, and then the mixture was heated at 130 °C for 18 h, cooled to 24 °C, centrifuged, and the supernatant was collected to obtain a black phosphorus quantum dot dispersion;

[0089] (2) The method for preparing the metal-organic fr...

Embodiment 2

[0092] Example 2 PEG-modified metal-organic framework ZIF-8 loaded with black phosphorus quantum dots and therapeutic drugs

[0093] A metal-organic framework ZIF-8 nano-microsphere was prepared. The difference between its preparation method and Example 1 is that in step (2), 0.31 g of zinc nitrate hexahydrate was replaced with 0.2 g of zinc nitrate, and the others remained unchanged. .

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Abstract

The invention relates to a composite nano-microsphere with a rapid mucus permeation effect as well as a preparation method and an application of the composite nano-microsphere. The composite nano-microsphere comprises a metal organic framework ZIF-8 and a hydrophilic high-molecular polymer modified on the surface of the metal organic framework ZIF-8, the metal organic framework ZIF-8 is loaded with black phosphorus quantum dots and active ingredients, and the hydrophilic high-molecular polymer is selected from polyethylene glycol. According to the invention, ZIF-8 is modified by hydrophilic PEG for the first time and is used for increasing the mucus penetration capability of ZIF-8, so that the mucus penetration capability of the composite nanoparticles is improved, and the targeting capability and the capability of penetrating through human physiological barrier obstruction are improved.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a composite nano-microsphere with fast mucus penetration and drug-carrying and controlled-release functions, and a preparation method and application thereof. Background technique [0002] Nanospheres are generally defined as particles in the scale range of 1-1000 nm, which exhibit unique properties such as large specific surface area, electromagnetic and optical behavior. The composition, size and surface properties of nanospheres can be artificially controlled during the preparation process, and nanospheres with specific properties can be synthesized as needed to encapsulate and protect therapeutic drugs, so that some poorly water-soluble drug molecules can be stably dispersed, and Prevents it from being excreted by various endogenous defense mechanisms during circulation in the body, including enzymatic degradation, immune degradation, reticuloendothel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61K9/50A61K47/10A61K47/04A61K47/24A61K41/00A61K45/00A61K31/704A61P35/00A61P11/00
CPCA61K49/0067A61K9/5031A61K9/5015A61K9/501A61K41/0042A61K45/00A61K31/704A61P35/00A61P11/00
Inventor 李志斌钱敏喻学锋
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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