Florfenicol powder for improving water solubility as well as preparation method and application of florfenicol powder

A technology of florfenicol and water solubility, which is applied in the fields of improving water solubility of florfenicol powder and its preparation and application, and can solve problems such as poor curative effect, increased biological resistance, poor water solubility of florfenicol, etc.

Active Publication Date: 2020-08-28
南京大方生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the poor water solubility of florfenicol, it brings a lot of inconvenience to clinical medication
In addition, with the widespread use of florfenicol leading to increased bioresistance leading to poor efficacy, there is a need to address this issue

Method used

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  • Florfenicol powder for improving water solubility as well as preparation method and application of florfenicol powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] According to parts by weight, it consists of 10 parts of florfenicol powder, 5 parts of citric acid, 3 parts of polyvinylpyrrolidone PVPK30, 70 parts of lactose, 2 parts of sodium lauryl sulfate, 5 parts of polyethylene glycol 6000, 2 parts Trimethoprim lactate and 3 parts of palm oil form Florfenicol powder.

[0023] A preparation method for improving water-soluble florfenicol powder, comprising the steps of:

[0024] 1) Weighing 5 parts of polyethylene glycol 6000, 3 parts of palm oil, 110 parts of distilled water and dissolving 10 parts of florfenicol powder at 53 degrees Celsius to obtain a mixture 1;

[0025] 2) Add 3 parts of polyvinylpyrrolidone PVPK30, 70 parts of lactose, 2 parts of sodium lauryl sulfate, and 2 parts of trimethoprim lactate to mixture 1, stir and dissolve at 53 degrees Celsius, and then spray dry to obtain mixture 2, Pass through a 40 mesh sieve;

[0026] 3) Add 5 parts of citric acid to mixture 2, mix evenly, and pass through a 40-mesh sieve...

Embodiment 2

[0029] According to parts by weight, it consists of 10 parts of florfenicol powder, 4 parts of citric acid, 3 parts of polyvinylpyrrolidone PVPK30, 69 parts of lactose, 3 parts of sodium lauryl sulfate, 5 parts of polyethylene glycol 6000, 3 parts Trimethoprim lactate and 3 parts of palm oil form Florfenicol powder.

[0030] A preparation method for improving water-soluble florfenicol powder, comprising the steps of:

[0031] 1) Weighing 5 parts of polyethylene glycol 6000, 3 parts of palm oil, 110 parts of distilled water and dissolving 10 parts of florfenicol powder at 53 degrees Celsius to obtain a mixture 1;

[0032] 2) Add 3 parts of polyvinylpyrrolidone PVPK30, 69 parts of lactose, 3 parts of sodium lauryl sulfate, and 3 parts of trimethoprim lactate to mixture 1, stir and dissolve at 53 degrees Celsius, and then spray dry to obtain mixture 2, Pass through a 40 mesh sieve;

[0033] 3) Add 4 parts of citric acid to mixture 2, mix evenly, and pass through a 40-mesh sieve...

Embodiment 3

[0036] According to parts by weight, it consists of 10 parts of florfenicol powder, 5 parts of citric acid, 3 parts of polyvinylpyrrolidone PVPK30, 69 parts of lactose, 2 parts of sodium lauryl sulfate, 5 parts of polyethylene glycol 6000, 3 parts Trimethoprim lactate and 3 parts of palm oil form Florfenicol powder.

[0037] A preparation method for improving water-soluble florfenicol powder, comprising the steps of:

[0038] 1) Weighing 5 parts of polyethylene glycol 6000, 3 parts of palm oil, 110 parts of distilled water and dissolving 10 parts of florfenicol powder at 53 degrees Celsius to obtain mixture 1;

[0039] 2) Add 3 parts of polyvinylpyrrolidone PVPK30, 69 parts of lactose, 2 parts of sodium lauryl sulfate, and 3 parts of trimethoprim lactate to mixture 1, stir and dissolve at 53 degrees Celsius, and then spray dry to obtain mixture 2, Pass through a 40-mesh sieve; 3) Add 5 parts of citric acid to the mixture 2, mix evenly, and pass through a 40-mesh sieve to obta...

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Abstract

The invention relates to florfenicol powder for improving water solubility as well as a preparation method and an application of the florfenicol powder. The powder is composed of the following components in parts by weight: 10 parts of florfenicol powder, 3-5 parts of citric acid, 2-3 parts of polyvinylpyrrolidone PVPK30, 50-60 parts of lactose, 2-4 parts of sodium lauryl sulfate, 5-7 parts of polyethylene glycol 6000, 2-3 parts of trimethoprim lactate and 2-4 parts of palm oil. Polyethylene glycol 6000, citric acid, polyvinylpyrrolidone PVPK30, lactose, sodium dodecyl sulfate and the palm oilare adopted, and various components are synergetic to improve water solubility of florfenicol and trimethoprim lactate, so that the curative effect of the florfenicol powder is optimal.

Description

technical field [0001] The invention relates to a water-soluble florfenicol powder and its preparation method and application. Background technique [0002] Florfenicol (Florfenicol) Chinese name: fluprofen; florfenicol; florfenicol, is a synthetic monofluoro derivative of thiamphenicol, white or off-white crystalline powder, odorless. Very slightly soluble in water and chloroform, slightly soluble in glacial acetic acid, soluble in methanol and ethanol. It is a new veterinary-specific broad-spectrum antibacterial drug of chloramphenicol that was successfully developed in the late 1980s. It is a special antibacterial drug for animals, which is used for the bacterial diseases of pigs, chickens and fish caused by sensitive bacteria, especially for respiratory system infection and intestinal infection. [0003] Due to the poor water solubility of florfenicol, it brings a lot of inconvenience to clinical medication. Furthermore, as widespread use of florfenicol has led to inc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/165A61K31/505A61K47/32A61K47/12A61K47/44A61K47/26A61K47/10A61P31/04
CPCA61K31/165A61K31/505A61K9/146A61K9/145A61P31/04A61K2300/00
Inventor 汤法银
Owner 南京大方生物工程有限公司
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