Traditional Chinese medicine composition and application thereof for preventing and treating neonatal piglet diarrhea by taking medicine for sows

A new-born piglet and composition technology, which is applied in the directions of drug combination, medical preparations containing active ingredients, and pharmaceutical formulations, can solve the problems affecting the disease defense ability and later growth of newborn piglets, and achieve the function of anti-tumor immune system. , Improve the body's immune system function, the effect of high medicinal value

Active Publication Date: 2022-02-08
浙江康嘉基因技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Since the health of the sow seriously affects the defense ability of newborn piglets against diseases and their later growth, it is still a key research field to seek measures to prevent and treat diarrhea in newborn piglets from the perspective of the mother

Method used

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  • Traditional Chinese medicine composition and application thereof for preventing and treating neonatal piglet diarrhea by taking medicine for sows
  • Traditional Chinese medicine composition and application thereof for preventing and treating neonatal piglet diarrhea by taking medicine for sows
  • Traditional Chinese medicine composition and application thereof for preventing and treating neonatal piglet diarrhea by taking medicine for sows

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation of embodiment 1 composition 1

[0026] According to the proportion of the prescription, weigh 10-20 parts of Bupleurum bupleurum, 10-20 parts of honeysuckle, 8-15 parts of astragalus polysaccharide, 10-20 parts of Houttuynia cordata, and 10-20 parts of forsythia. After cleaning and removing impurities, add 8- Purified water with 10 times the weight of medicinal materials, decocted 2-3 times, 1 hour each time, filtered and combined the filtrate, concentrated into a thick paste with a relative density of 1.32-1.35 (50-55°C) by conventional methods, and added appropriate amount of auxiliary materials, Such as soluble starch, sucrose powder, etc., and dry to obtain powder.

Embodiment 2

[0027] The preparation of embodiment 2 composition 2

[0028] According to the proportion of the prescription, weigh 5-15 parts of Bupleurum, 5-15 parts of honeysuckle, 5-15 parts of astragalus polysaccharide, 5-15 parts of Houttuynia cordata, 5-15 parts of forsythia, after cleaning and removing impurities, add 8- Purified water 10 times the weight of medicinal materials, decocted 2-3 times, 1 hour each time, filtered and combined the filtrate. Add 2 times the volume of filtrate water for injection (V:V=1:2), filter through a 0.45μm organic filter to obtain the filtrate; then sterilize the filtrate at 121°C and 0.15Mpa for 20min to obtain the aqueous solution.

[0029] Under sterile conditions, porcine IFN-γ is added to the aqueous preparation at a weight ratio of 20-200 μg / g to obtain composition 2.

Embodiment 3

[0030] Embodiment 3 composition clinical trial research

[0031] 3.1 Test traditional Chinese medicine composition:

[0032]

[0033]

[0034] 3.2 Test location: A large-scale pig farm in Zhejiang, with 1,000 sows in stock. Before the test, piglets in the farrowing room of the pig farm had unexplained diarrhea. Conventional treatment (such as antibiotic therapy and oral rehydration salts, etc.) had no obvious Effect.

[0035]3.3 Test animals: select 83 newborn sows with similar parity, body weight, age and delivery period, and divide them into 8 groups at random, which are respectively Chinese medicine composition of the present invention and a control group. The selected sows had the same immunization procedures, and the feeding and management conditions were the same during pregnancy and postpartum, and they were all kept in a single stall.

[0036] 3.4 Test plan

[0037] 3.4.1 Treatment plan: Composition 1 is administered orally by mixed feeding, administered twice...

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Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating diarrhea of ​​newborn piglets in sows. The composition comprises composition 1 and composition 2. The composition 1 is composed of the following components in parts by weight: 10-20 parts of Bupleurum bupleuri, 10-20 parts of honeysuckle, 8-15 parts of astragalus polysaccharide, 10-20 parts of Houttuynia cordata, and 10-20 parts of forsythia. The composition 2 is a water injection, which consists of the following components in parts by weight: 5-15 parts of Bupleurum, 5-15 parts of Honeysuckle, 5-15 parts of Astragalus polysaccharide, 5-15 parts of Houttuynia cordata, 5-15 parts, the composition 2 also contains porcine IFN-γ, and the content of the porcine IFN-γ is 20-200 μg / g. The present invention greatly improves the health status and immunity of sows by using the composition 1 and composition 2 in combination, and greatly improves the innate defense ability of piglets against diarrhea.

Description

technical field [0001] The invention relates to a veterinary medicine, in particular to a traditional Chinese medicine composition for preventing and treating diarrhea of ​​newborn piglets by taking medicine for sows and an application thereof. Background technique [0002] The pig industry occupies a dominant position in the development of animal husbandry in my country, and the health of pigs and the survival rate of newborn piglets have become the key factors restricting the development of the industry. Since 2010, large-scale pig farms in my country have experienced a pandemic trend of newborn piglet diarrhea. The disease has high morbidity and mortality. In severe large-scale pig farms, piglets with severe disease have diarrhea in the whole litter of newborn piglets, and the mortality rate Up to more than 80%, resulting in heavy losses in pig farms, it has become a major problem affecting today's pig industry. The main impact of the disease is reflected in higher mortal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/21A61K36/78A61P1/12A61K31/715
CPCA61K36/233A61K36/355A61K31/715A61K36/78A61K36/634A61K38/217A61P1/12A61K2300/00
Inventor 查银河舒建洪李复煌杨芳黄磊盛敏成
Owner 浙江康嘉基因技术有限公司
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