Composition for nasal cavity

A composition and a nasal technology, which are applied in the prevention or treatment of nasal dryness and allergies, can solve problems such as unsatisfactory curative effect and short action time, and achieve the effect of increasing external stimulation threshold and reducing the probability of nasal diseases.

Active Publication Date: 2020-09-01
BLOOMAGE BIOTECHNOLOGY CORP LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, it is mainly used in the field of skin care, and there are very few nasal spray products containing tetrahydromethylpyrimidinecarboxylic acid used in the nasal cavity abroad, but the curative effect is not satisfactory due to the short action time

Method used

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  • Composition for nasal cavity
  • Composition for nasal cavity
  • Composition for nasal cavity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] Under stirring, add 0.2g of hyaluronic acid tetrabutylammonium salt (molecular weight: 3 million Daltons) into 80g of purified water at 80-95°C, stir to dissolve completely, and then add 0.1g of tetrahydromethylpyrimidinecarboxylic acid Add, stir at 80-95°C until dissolved, then slowly stir and keep warm for 25 minutes, then slowly cool down to 30-40°C, then add 3.8g hyaluronic acid tetrabutylammonium salt (molecular weight: 0.1 thousand Daltons) , stir to make it completely dissolve, and obtain phase A material; at the same time, add 0.15g of PPG-26 butane-26 / PEG-40 hydrogenated castor oil, 0.7g of phenoxyethanol, 0.1g of ethylhexylglycerin and 0.015g of peppermint essential oil Add up to 10g of purified water to obtain the material of phase B; then add the material of phase B to the material of phase A, and wash the container containing the material of phase B with a small amount of purified water, pour the cleaning solution into phase A together, and then add purified...

Embodiment 2

[0092] Under stirring, add 0.15g of tetrabutylammonium hyaluronic acid (molecular weight: 1.2 million Daltons) into 80g of purified water at 80-95°C, stir to dissolve completely, and then add 6g of tetrahydromethylpyrimidinecarboxylic acid into , stir at 80-95°C until dissolved, then slowly stir and keep warm for 25 minutes, then slowly cool down to 30-40°C, then add 0.15g hyaluronic acid tetrabutylammonium salt (molecular weight: 50,000 Daltons), Stir to dissolve completely to obtain phase A material; at the same time, add 0.15g of PPG-26 butane-26 / PEG-40 hydrogenated castor oil, 0.7g of phenoxyethanol, 0.1g of ethylhexylglycerin and 0.015g of peppermint essential oil to 10g Purified water to obtain phase B material; then add phase B material to phase A material, and clean the container containing phase B material with a small amount of purified water, pour the cleaning liquid into phase A together, and then add purified water to 100g of the material liquid, Stir to make it e...

Embodiment 3

[0094] Under stirring, add 0.5g of hyaluronic acid tetrabutylammonium salt (molecular weight: 1.8 million Daltons) into 80g of purified water at 80-95°C, stir to dissolve it completely, and then add 0.5g of tetrahydromethylpyrimidinecarboxylic acid Add, stir at 80-95°C until dissolved, then slowly stir and keep warm for 25 minutes, then slowly cool down to 30-40°C, then add 1.0g hyaluronic acid tetrabutylammonium salt (molecular weight: 10,000 Daltons) , stir to make it completely dissolve, and obtain phase A material; at the same time, add 0.15g of PPG-26 butane-26 / PEG-40 hydrogenated castor oil, 0.7g of phenoxyethanol, 0.1g of ethylhexylglycerin and 0.015g of peppermint essential oil Add up to 10g of purified water to obtain the material of phase B; then add the material of phase B to the material of phase A, and wash the container containing the material of phase B with a small amount of purified water, pour the cleaning solution into phase A together, and then add purified ...

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Abstract

The invention relates to a composition for a nasal cavity, which relates to the field of nasal cavity allergy resistance, in particular to a nasal cavity composition which comprises tetrahydromethylpyrimidine carboxylic acid and hyaluronate, the tetrahydromethylpyrimidine carboxylic acid and the hyaluronate synergistically protect nasal mucosa from being stimulated by external allergens, and meanwhile, rapid repair of damaged nasal mucosa is facilitated, and nasal cavity problems of nasal cavity dryness, nasal cavity allergy and the like are synergistically prevented or treated.

Description

technical field [0001] The invention belongs to the field of preventing or treating nasal cavity dryness and allergy, and in particular relates to a composition for nasal cavity, which mainly comprises tetrahydromethylpyrimidine carboxylic acid and hyaluronic acid salt. Background technique [0002] At present, due to the decline in air quality caused by air pollution, more and more people have nasal allergies caused by pollen, indoor and outdoor dust, bacteria, animal fur, etc. In addition, there is less rain in autumn and winter in the north, and nasal congestion caused by dry climate Dry discomfort is also common. Dryness of the nasal cavity can easily lead to weak immunity of the nasal cavity. In severe cases, small wounds may appear, and at the same time, the ability of the nasal cavity to defend against external pollution is reduced, so this also aggravates the further occurrence of rhinitis. [0003] The formation mechanism of allergic rhinitis (AR): when the body co...

Claims

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Application Information

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IPC IPC(8): A61K31/728A61K9/08A61K9/06A61P37/08A61P11/02A61K31/505
CPCA61K9/0043A61K9/06A61K9/08A61K31/505A61K31/728A61P11/02A61P37/08A61K2300/00
Inventor 李霞王玉玲王琳琳邵萌郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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