Application of talaroconvolutin A in anticancer drugs

A drug and cancer technology, applied in the field of microbial metabolites, to reduce drug resistance, avoid toxic and side effects, and reduce side effects
CN111643497BActive Publication Date: 2021-06-29JINING MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JINING MEDICAL UNIV
Publication Date
2021-06-29

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Abstract

The invention belongs to the application field of microbial metabolites, and focuses on the application of Talaroconvolutin A in the preparation of drugs for treating colon, rectal cancer or lung cancer. Talaroconvolutin A kills cancer cells at a concentration of 0.5-50 μg / mL in vitro, and the lowest concentration that effectively kills cancer cells in 48 hours is 2 μg / mL; the effective concentration for inhibiting colon cancer cell colony formation is 2 μg / mL. IC 50 It is less than 1 μg / mL, and the effective concentration at the animal level is 5-20 mg / kg. The beneficial effects of the present invention are: IC 50 Low, minimal IC of Talaroconvolutin A at the cellular level 50 Less than 1μg / mL, the effective concentration in animals can be as low as 5mg / kg, which is obviously better than cisplatin chemotherapy drugs, and has less toxic and side effects to animals.
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Description

technical field

[0001] The invention belongs to the field of application of microbial metabolites, and in particular relates to the application of Talaroconvolutin A in the preparation of anticancer drugs, especially digestive system cancer drugs, respiratory system cancer drugs or food. Background technique

[0002] Colon cancer, rectal cancer and other digestive system cancers are a kind of digestive tract tumors that occur in the human colon mucosal epithelium. With the lack of low-fiber foods and trace elements and vitamins in the human diet, the continuation of bad living habits, and the increase in the mental pressure of survival, patients are increasingly migrating to younger ages, and the incidence rate is higher in men. The incidence of bowel cancer is increasing worldwide.

[0003] In the current medical level, comprehensive treatment is the mainstream direction for the treatment of the above-mentioned digestive system cancers, that is, the organic combination of ...

Claims

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