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A traditional Chinese medicine composition for inhibiting Helicobacter pylori and preparation method thereof

A technology of Helicobacter pylori and composition, applied in the field of traditional Chinese medicine composition for inhibiting Helicobacter pylori and its preparation, can solve the problems such as the increase of Hp strains and the lack of drugs for effectively inhibiting Hp, and achieve strong inhibitory effect and drug resistance incidence Low, less adverse effects

Active Publication Date: 2021-04-20
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the technical problems such as the increase of antibiotic-resistant Hp strains in the prior art and the lack of drugs for effectively inhibiting Hp, and to provide a Chinese medicine composition for inhibiting Hp and a preparation method thereof

Method used

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  • A traditional Chinese medicine composition for inhibiting Helicobacter pylori and preparation method thereof
  • A traditional Chinese medicine composition for inhibiting Helicobacter pylori and preparation method thereof
  • A traditional Chinese medicine composition for inhibiting Helicobacter pylori and preparation method thereof

Examples

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Effect test

Embodiment 1

[0023] A traditional Chinese medicine composition for inhibiting Helicobacter pylori, comprising 15 parts of green fruit, 6 parts of Huai Mi and 5 parts of licorice in parts by weight.

[0024] The preparation method of the above-mentioned Chinese medicine composition for inhibiting Helicobacter pylori is characterized in that it comprises the following steps:

[0025] S1. Mix green fruit, pagoda japonica and licorice according to the proportion, and add 10-15 mL of water per gram of medicinal material;

[0026] S2. Boiling the mixture obtained in step S1 at a voltage of 220 V in an electric heating mantle, and then decocting at a voltage of 100 V for 1 to 3 h to obtain an extract;

[0027] S3. Purify the extract obtained in step S2. The specific purification method is: filter the extract with two layers of medium-speed filter paper while it is hot, remove the filter residue, concentrate the filtrate by rotary evaporation under reduced pressure, refrigerate at -80°C overnight...

Embodiment 2

[0029] A traditional Chinese medicine composition for inhibiting Helicobacter pylori, comprising 5 parts of green fruit, 1 part of Sophora japonica and 0.5 part of licorice in parts by weight.

[0030] The preparation method of the above-mentioned Chinese medicine composition for inhibiting Helicobacter pylori is characterized in that it comprises the following steps:.

[0031] S1. Mix green fruit, pagoda japonica and licorice according to the proportion, and add 10-15 mL of water per gram of medicinal material;

[0032] S2. The mixture obtained in step S1 is boiled at a voltage of 220 V in an electric heating mantle, and then decocted at a voltage of 100 V for 1 to 3 h to obtain an extract;

[0033] S3. Purify the extract obtained in step S2. The specific purification method is: filter the extract with two layers of medium-speed filter paper while it is hot, remove the filter residue, concentrate the filtrate by rotary evaporation under reduced pressure, refrigerate at -80°C...

Embodiment 3

[0035] A traditional Chinese medicine composition for inhibiting Helicobacter pylori, comprising 10 parts of green fruit, 3 parts of Huai Mi and 1 part of licorice in parts by weight.

[0036] The preparation method of the above-mentioned Chinese medicine composition for inhibiting Helicobacter pylori is characterized in that it comprises the following steps:

[0037] S1. Mix green fruit, pagoda japonica and licorice according to the proportion, and add 10-15 mL of water per gram of medicinal material;

[0038] S2. Boiling the mixture obtained in step S1 at a voltage of 220 V in an electric heating mantle, and then decocting at a voltage of 100 V for 1 to 3 h to obtain an extract;

[0039] S3. Purify the extract obtained in step S2. The specific purification method is: filter the extract with two layers of medium-speed filter paper while it is hot, remove the filter residue, concentrate the filtrate by rotary evaporation under reduced pressure, refrigerate at -80°C overnight ...

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Abstract

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for inhibiting Helicobacter pylori and a preparation method thereof, which comprises 5-15 parts of green fruit, 0-6 parts of Sophora japonica and 0-5 parts of licorice in parts by weight. The traditional Chinese medicine composition for inhibiting Helicobacter pylori disclosed by the invention has the action characteristics of multi-components, multi-paths and multi-targets, and the incidence of drug resistance of the traditional Chinese medicine therapy is low, and adverse reactions are few, and patients' medication compliance is good. The composition of the invention has reasonable compatibility, has a strong inhibitory effect on antibiotic-sensitive strains and drug-resistant strains of Helicobacter pylori, avoids bitter cold and hurts the stomach, is suitable for Helicobacter pylori-infected patients, and the application of traditional Chinese medicine can reduce the use of antibiotics thereby Reduce the drug resistance rate of Helicobacter pylori.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for inhibiting Helicobacter pylori and a preparation method thereof. [0002] technical background [0003] Helicobacter pylori ( Helicobacter pylori , Hp) is a helical, microaerophilic, Gram-negative bacterium that colonizes the stomach of about 50% of the world's population. Studies have shown that the rate of H. pylori infection has continued to increase over the past three decades. The fifth national consensus report on the management of Helicobacter pylori infection pointed out that Hp infection is an infectious disease, regardless of whether there are clinical symptoms, once infected, eradication treatment should be carried out. Hp infection is closely related to a variety of gastrointestinal diseases such as gastritis, peptic ulcer, mucosa-associated lymphoid tissue lymphoma and gastric cancer, and is also related to ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/489A61P31/04A23L33/105
CPCA23V2002/00A61K36/32A61K36/484A61K36/489A61K2236/331A23L33/105A61P31/04A61K2300/00A23V2200/32
Inventor 姚美村彭昶申雪袁月梅严家慧张唯佳陈鹏婷
Owner SHANDONG NEWTIME PHARMA
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