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Bone scaffold material for drug loading and preparation method thereof, functional hybrid bone scaffold and preparation method of functional hybrid bone scaffold

A bone scaffold and hybrid technology, which is applied in the field of drug-loaded bone scaffold materials, can solve the problem that growth factors cannot have both osteogenic and angiogenic functions, limit the clinical transformation and application of bone scaffold materials, and have poor osteogenesis and angiogenesis. and other problems, to achieve the effects of excellent degradability, good loading effect and controllable degradation rate

Active Publication Date: 2020-09-11
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still deficiencies in current bone defect repair: growth factors are expensive and have low local bioavailability; a single growth factor cannot have both osteogenesis and angiogenesis effects; Clinical transformation and application of materials
[0003] Under the idea of ​​using bone scaffold materials to load drugs, common loading materials cannot meet the demand

Method used

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  • Bone scaffold material for drug loading and preparation method thereof, functional hybrid bone scaffold and preparation method of functional hybrid bone scaffold
  • Bone scaffold material for drug loading and preparation method thereof, functional hybrid bone scaffold and preparation method of functional hybrid bone scaffold
  • Bone scaffold material for drug loading and preparation method thereof, functional hybrid bone scaffold and preparation method of functional hybrid bone scaffold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] A bone scaffold material for drug loading, comprising an organic template and a deposition material, the deposition material is evenly deposited on the organic template to form an airgel;

[0052] The organic template includes nanocellulose / collagen composite scaffold, and the deposition material includes hydroxyapatite.

[0053] First carry out the preparation of nano-hydroxyapatite:

[0054] At a stirring speed of 300 rpm and a temperature of 60° C., 100 ml of 0.3 mol / L diammonium hydrogen phosphate aqueous solution was added dropwise to 100 ml / L of calcium nitrate solution to react for 2 hours. At the same time, an appropriate amount of ammonia water was added during the reaction to adjust the pH of the reaction system to 10. After the reaction was completed, it was left at room temperature for 24 hours, then centrifuged at 5000 rpm / speed and washed 5 times, and the resulting precipitate was freeze-dried at -50°C for 48 hours to obtain nano-hydroxyapatite.

[0055]...

Embodiment 2

[0062] A bone scaffold material for drug loading, comprising an organic template and a deposition material, the deposition material is evenly deposited on the organic template to form an airgel;

[0063] The organic template includes nanocellulose / collagen composite scaffold, and the deposition material includes hydroxyapatite.

[0064] First carry out the preparation of nano-hydroxyapatite:

[0065] At a stirring speed of 300 rpm and a temperature of 60° C., 100 ml of 0.3 mol / L diammonium hydrogen phosphate aqueous solution was added dropwise to 100 ml / L of calcium nitrate solution to react for 2 hours. At the same time, an appropriate amount of ammonia water was added during the reaction to adjust the pH of the reaction system to 10. After the reaction was completed, it was left at room temperature for 24 hours, then centrifuged at 5000 rpm / speed and washed 5 times, and the resulting precipitate was freeze-dried at -50°C for 48 hours to obtain nano-hydroxyapatite.

[0066]...

Embodiment 3

[0073] A bone scaffold material for drug loading, comprising an organic template and a deposition material, the deposition material is evenly deposited on the organic template to form an airgel;

[0074] The organic template includes nanocellulose / collagen composite scaffold, and the deposition material includes hydroxyapatite.

[0075] First carry out the preparation of nano-hydroxyapatite:

[0076] At a stirring speed of 300 rpm and a temperature of 60° C., 100 ml of 0.3 mol / L diammonium hydrogen phosphate aqueous solution was added dropwise to 100 ml / L of calcium nitrate solution to react for 2 hours. At the same time, an appropriate amount of ammonia water was added during the reaction to adjust the pH of the reaction system to 10. After the reaction was completed, it was left at room temperature for 24 hours, then centrifuged at 5000 rpm / speed and washed 5 times, and the resulting precipitate was freeze-dried at -50°C for 48 hours to obtain nano-hydroxyapatite.

[0077]...

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Abstract

The invention discloses a bone scaffold material for drug loading and relates to the field of bone repair materials. The invention provides the bone scaffold material for drug loading. The bone scaffold material comprises an organic template and a deposition material, wherein the deposition material is uniformly deposited on the organic template to form an aerogel, so as to achieve drug loading through the bone scaffold material and to achieve the targets that a load material has certain mechanical strength and high drug loading capacity and the material structure is conducive to a bone repairprocess at the same time. The invention further provides a functional hybrid aerogel bone scaffold. The functional hybrid aerogel bone scaffold comprises the prepared bone scaffold material for drugloading; and functional materials are loaded on the bone scaffold material, so that the problems that growth factors are expensive and local bioavailability is low when the growth factors are loaded on an existing bone scaffold, a single growth factor cannot balance the osteogenesis effect and the angiogenesis effect, and clinical transformation and application of the bone scaffold material are limited due to poor internal osteogenesis and angiogenesis inducibility of a biomimetic bone scaffold material are solved.

Description

technical field [0001] The invention relates to the field of bone repair materials, in particular to a bone scaffold material used for drug loading. Background technique [0002] Bone defects can be caused by various reasons such as tumor, inflammation and trauma. At present, autologous bone and allogeneic bone transplantation are still the main treatment methods for reconstructing bone defects. However, autologous bone and allogeneic bone transplantation have risks such as limited donors, complications at the donor site, immunogenic reactions, and disease transmission. Therefore, there is an urgent need to develop artificial bone scaffold materials that are both osteoinductive and angiogenic to improve the repairing effect of bone defects. Bone scaffold materials loaded with growth factors (bone morphogenetic protein or vascular endothelial growth factor) to promote osteogenesis and angiogenesis studies have made it possible for artificial bone scaffold materials to repair...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/12A61L27/24A61L27/50A61L27/54A61L27/56A61L27/58
CPCA61L27/20A61L27/24A61L27/12A61L27/58A61L27/50A61L27/56A61L27/54A61L2300/252A61L2300/412A61L2300/602C08L1/02
Inventor 王浩洋王端周宗科夏和生蹇志文
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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