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Composition for treating skin cell damage caused by fine dust, for strengthening skin barrier, and for Anti-aging or Anti-inflammation, containing mentha arvensis extract

A technology of skin cells and compositions, applied in skin care preparations, cosmetics, food science, etc., can solve problems such as skin discoloration and rough skin surface

Pending Publication Date: 2020-09-11
AMOREPACIFIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, nowadays, due to various reasons such as artificial temperature control of cooling / heating due to changes in the environment or lifestyle, skin stress due to the stress of social life and environmental pollution, frequent washing due to makeup habits, and due to The natural aging of the skin due to aging, the moisture of the stratum corneum decreases, the skin becomes dry, the skin surface becomes rough, and the skin becomes sagging and looks discolored due to lack of moisture, etc.

Method used

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  • Composition for treating skin cell damage caused by fine dust, for strengthening skin barrier, and for Anti-aging or Anti-inflammation, containing mentha arvensis extract
  • Composition for treating skin cell damage caused by fine dust, for strengthening skin barrier, and for Anti-aging or Anti-inflammation, containing mentha arvensis extract
  • Composition for treating skin cell damage caused by fine dust, for strengthening skin barrier, and for Anti-aging or Anti-inflammation, containing mentha arvensis extract

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0108] Example 1: Preparation of Peppermint Extract

[0109] Wild mint leaves and acetic acid bacteria (Acetobacter aceti) were prepared and fermented at 26° C. for 48 hours. Then, using an extraction solvent obtained by mixing purified water and ethanol (ie, 70% ethanol) at a ratio of 3:7 as an extraction solvent, the fermentation product was extracted at room temperature. After extraction at room temperature, primary filtration is performed to remove solid matter contained in the extract. Then, the extract was concentrated to remove ethanol, followed by isolation and purification. Then, the resultant was subjected to centrifugation and secondary filtration, and then dried to obtain a wild peppermint extract.

example 2

[0110] Example 2: Dust collection and extraction

[0111]Microdust was collected using a low volume air sampler (Sensidyne, Gillian, FL, U.S.A.). The filters and denuders of the filter pack were replaced at about 10:00 am on each measurement day to collect samples for about 24 hours. In Sunpung-gu, Seoul (Korea University of Foreign Studies International Research Center, the roof of the 6th floor of the dormitory building in Cheonnyeong-gu, Gyeonggi-do, Yongin-si) collects fine dust every day for 28 days. The measurement time was measured by starting a timer when the vacuum pump was turned on and recording the time of the timer when the vacuum pump was turned off. The collection flow rate was set at 16.7 L / min. The flow rate was measured with a flow meter (Model 4143, TSI Inc.) at the beginning of the measurement and again at the end of the measurement. The Teflon filters in the filter pack were weighed before and after collection. The Teflon filter was dried in a desiccat...

example 3

[0112] Example 3: Culture of Keratinocyte Line (Normal Human)

[0113] Keratinocyte cell line (normal) was purchased from Lonza Inc. (Walkersville, Maryland, USA), subcultured (subcultured), and then incubated at 37°C and 5% CO 2 under the condition of CO 2 Cultivated in an incubator. Cell culture was performed according to Lonza's guidelines. KGM-2bullet kit CC-4152 (ingredients: BPE (bovine pituitary extract)), human epidermal growth factor (human epidermal growth factor, hEGF), insulin, hydrocortisone, transferrin, adrenal Epinephrine, and KGM-2 bullet kit CC-3107 added with GA-1000 (gentamycin suflate + amphotericin-B), added to 500ml of KBM- 2CC-3103 medium to prepare medium for cell culture.

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PUM

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Abstract

The present specification relates to an external-use skin preparation composition containing a Mentha Arvensis extract as an active ingredient, and provides a composition for treating skin damage caused by fine dust, the composition regulating, to a normal level, the expression of any one or more selected from the group consisting of IL-1a(NM_000575), IL-1B(NM_000576), IL-36G(NM_019618), S100A7(NM_002963), LCE3D(NM_032563), PTGS2(NM_000963) and XDH(NM_000379), which are genes in skin cells and of which the expression is affected by fine dust. By using the composition for treating skin damage caused by fine dust, gene expression changed by fine dust can return to the normal level such that skin cell damage can be treated.

Description

technical field [0001] The present invention relates to a composition for the care of fine dust damage to skin cells, especially a composition comprising a wild peppermint extract, and which treats skin cell damage by significantly altering biomarkers, etc., which are expression levels Skin cell genes altered by fine dust compared to normal. Background technique [0002] The skin is the part of the body that is directly exposed to the external environment. The skin not only acts as a protective layer that protects our body's vital organs, but also regulates water evaporation and protects the body from external infections. However, even though the skin is designed to prevent viruses from entering from the outside, excessive exposure of the skin to ultraviolet rays or pollutants can cause skin irritation. In particular, the skin is damaged by Asian dust accompanied by strong wind and dirt. [0003] Asian Dust is a phenomenon in which small grains of sand or red clay float u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K36/534A23L33/105A61Q19/00A61Q19/08
CPCA23L33/105A61K8/97A61K36/534A61Q19/00A61Q19/08
Inventor 金亨俊金美珍李泰龙
Owner AMOREPACIFIC CORP
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