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DNA methylation marker for colorectal cancer, and method and kit for detecting colorectal cancer by using DNA methylation marker

A methylation marker, colorectal cancer technology, applied in the biological field, can solve the problems of feeling uncomfortable or even disgusted, decreased willingness of subjects to be screened, and poor compliance.

Active Publication Date: 2020-09-15
PEKING UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The current means of diagnosing CRC, such as colonoscopy, is an invasive examination, and the patients who are examined may feel uncomfortable or even disgusted during the examination
The fecal occult blood test requires multiple sampling, which will bring a lot of inconvenience to the patient, resulting in a decrease in the willingness of the subject to be screened and poor compliance

Method used

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  • DNA methylation marker for colorectal cancer, and method and kit for detecting colorectal cancer by using DNA methylation marker
  • DNA methylation marker for colorectal cancer, and method and kit for detecting colorectal cancer by using DNA methylation marker
  • DNA methylation marker for colorectal cancer, and method and kit for detecting colorectal cancer by using DNA methylation marker

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Embodiment Construction

[0059] The present invention will be further described below in conjunction with non-limiting examples. Unless otherwise indicated, parts and percentages are by weight and temperatures are in degrees Celsius. It will be understood by those skilled in the art that the following examples, while indicating preferred embodiments of the invention, are given by way of illustration only, and all reagents used are commercially available.

[0060] general method

[0061] I. Obtain a sample

[0062] A total of 66 cases of paired colorectal cancer and paracancerous tissues were obtained, including 33 cases of colorectal cancer and paracancerous tissues. As a training group, plasma from 73 colorectal patients and 70 age- and sex-matched cancer-free volunteers were obtained. As a validation group, plasma from 74 colorectal patients and 66 age- and sex-matched cancer-free volunteers were obtained. Among them, 4 samples (2 patients and 2 controls) in the training group and 5 samples (3...

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Abstract

The invention relates to a DNA methylation marker for predicting the risk of colorectal cancer (CRC), and a method and kit for detecting colorectal cancer by using the DNA methylation marker.

Description

technical field [0001] The invention belongs to the field of biotechnology. In particular, the present invention relates to DNA methylation markers for predicting the risk of colorectal cancer (CRC) and methods and kits for detecting colorectal cancer using the same. Background technique [0002] Worldwide, many people are diagnosed with CRC each year, and many patients die from the disease. Although existing treatments (including surgery, radiotherapy, and chemotherapy) have significant clinical value for CRC, the recurrence and metastasis of cancer after surgery make these treatments unable to successfully cure colorectal cancer. Therefore, early diagnosis of CRC can not only reduce mortality, but also reduce the cost of surgical treatment. [0003] The current means of diagnosing CRC, such as colonoscopy, is an invasive examination, and the examined patients may feel uncomfortable or even disgusted during the examination. The fecal occult blood test requires multiple s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12N15/11
CPCC12Q1/6886C12Q2600/106C12Q2600/154
Inventor 汤富酬付卫文路周鑫李静宜刘晓萌任杰
Owner PEKING UNIV
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