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Intragastric superabsorbent gel primary product and preparation method thereof, intragastric superabsorbent gel and preparation method thereof, and weight reducing composition

A water-absorbent polymer and superabsorbent technology, applied in the field of medicine, can solve the problems of prone to ulcers and other complications, gastric perforation, death, etc., and achieve the effect of responsive destruction, reduced intake, and increased satiety

Active Publication Date: 2020-09-25
王萌燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to being placed in the stomach for several months, the balloon rubs against the stomach wall, which is prone to ulcers and other complications. In severe cases, gastric perforation or even death may occur

Method used

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  • Intragastric superabsorbent gel primary product and preparation method thereof, intragastric superabsorbent gel and preparation method thereof, and weight reducing composition
  • Intragastric superabsorbent gel primary product and preparation method thereof, intragastric superabsorbent gel and preparation method thereof, and weight reducing composition
  • Intragastric superabsorbent gel primary product and preparation method thereof, intragastric superabsorbent gel and preparation method thereof, and weight reducing composition

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preparation example Construction

[0067] In addition, the present application also provides a method for preparing the primary superabsorbent hydrogel in the stomach according to any one of the foregoing embodiments, for example, it may include the following steps:

[0068] The above-mentioned natural polysaccharide water-absorbing polymer is mixed with a responsive crosslinking agent to carry out self-crosslinking reaction.

[0069] In an optional embodiment, the self-crosslinking is performed at 25-120°C for 24-96 hours, preferably, the self-crosslinking is performed at 37°C. The level of temperature and the length of time mainly affect the degree of crosslinking, and at the same time affect the water absorption of the gel. The higher the crosslinking temperature / or the longer the crosslinking time, the higher the degree of crosslinking, the lower the corresponding water absorption; otherwise, the lower the degree of crosslinking, the higher the water absorption.

[0070] In a specific implementation, it is...

Embodiment 1

[0106] The present embodiment provides an intragastric superabsorbent gel, which is prepared through the following steps:

[0107] 60g of carboxymethyl cellulose (measured according to the third method of Chinese Pharmacopoeia General Principle 0633, the viscosity of 2% solution is 3000mPa·s) was added to an appropriate amount of purified water, and stirred for 24h under the condition of 200rpm to form a concentration of 8wt% of carboxymethyl cellulose. Cellulose Homogeneous Solution.

[0108] The above homogeneous solution was mixed with 0.02g cystine, 0.2g EDC (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride) and 0.3g NHS (N-hydroxysuccinimide) ) together at 37°C for a cross-linking reaction for 24 hours, the above-mentioned cross-linked product is ground for the first time with a grinder, and the particles of 100-1200 μm are obtained by screening with a sieving machine, and then the sieved particles are transferred to the washing tank, Under normal temperature ...

Embodiment 2

[0114] The present embodiment provides an intragastric superabsorbent gel, which is different from Embodiment 1 in that:

[0115] The natural polysaccharide water-absorbing polymer, responsive cross-linking agent and auxiliary materials used in the preparation are the following substances:

[0116] 60g hydroxyethyl cellulose (measured according to the third method of Chinese Pharmacopoeia 0633, the viscosity of 2% solution is 6000mPa·s) to form a 10wt% solution, 0.3g PEG-cystine (PEG molecular weight is 4000), 0.2gEDC, 0.3gNHS, 0.2g sodium carbonate, 0.18g silica and 0.13g titanium dioxide.

[0117] The self-crosslinking reaction was carried out at 37°C for 48h.

[0118] The rest of the preparation process and conditions are the same as in Example 1.

[0119] The chemical structural formula of the intragastric superabsorbent gel prepared in this example is as follows:

[0120]

[0121] The compressive strength of the intragastric superabsorbent gel was 28 kPa, and the wa...

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Abstract

The invention discloses an intragastric superabsorbent gel primary product and a preparation method thereof, intragastric superabsorbent gel and a preparation method thereof, and a weight reducing composition, and belongs to the technical field of medicines. The structural formula of the hydrogel primary product is as shown in the specification, wherein R1 represents COONa, COOK, CH2OCH2OCOONa orCH2OCH2CH2OH, etc.; R2 is O or NH, etc.; R3 is O, NH, O (CH2CH2O) n4, [CH2CH (OH)] n5 or (CH2CH2) y, etc.,; and R4 is OH, NHCOCH3 or NH2, etc.; and n1 to n5, x and y are integers greater than 0. The hydrogel primary product can increase the satiety of a patient and reduce the weight by reducing the intake, and is high in biocompatibility. The intragastric superabsorbent gel and the weight reducingcomposition also have the above effects, and the weight reducing composition can also avoid the risk that the stomach enters the small intestine to block the small intestine after being emptied. Thepreparation method of the substances is simple and easy to operate.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a primary product of intragastric superabsorbent hydrogel and a preparation method thereof, intragastric superabsorbent hydrogel and a preparation method thereof, and a weight-reducing composition. Background technique [0002] According to the World Health Organization, more than 1.9 billion adults aged 18 and over were overweight in 2016, and more than 650 million of them were obese. 39% of adults age 18 and over are overweight and 13% are obese. At the same time, according to the data from the World Data Atlas analysis platform, the obesity rates of men and women in the United States are as high as 35.5% and 37.0% respectively, which has become part of the epidemic, and only 20% are morbidly obese. At the same time, obesity often leads to the occurrence of many complications, including cardiovascular disease, diabetes and obstructive sleep apnea. The current treatment meth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L1/28C08L5/08C08L5/04C08L71/02C08K3/36C08K3/22C08K3/26A61K31/717A61K31/722A61K31/716A61P3/04
CPCC08J3/075C08J3/246A61K31/717A61K31/722A61K31/716A61P3/04C08J2301/28C08J2305/08C08J2305/04C08J2471/02C08K3/36C08K2003/2241C08K2003/262
Inventor 王萌燕彭满秀
Owner 王萌燕
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