Oral administration formulation of blueberry extract as coadjuvant for preserving health of human precorneal film

Abstract

The invention relates to a nutraceutical formulation of blueberry extract, fish oil (omega-3 and omega-6), recombinant human lactoferrin, vitamin A and vitamin E, for human oral consumption. The invention belongs to the field of ophthalmology and has been developed as a coadjuvant for preserving the health of the precorneal film and of the eye surface. The formulation contains an extract of natural origin (Vaccinium myrtillus L) with antioxidant and anti-inflammatory properties; it also uses eicosapentaenoic acid (EPA), omega-6, and docosahexaenoic acid (DHA), omega-3, obtained from fish oil and which, together with lactoferrin, vitamin A and vitamin E, improves tear quality, since these compounds have anti-microbial and anti-inflammatory effects. The formulation has been designed as a coadjuvant for preserving the health of the precorneal film. No formulation for oral administration of a blueberry extract together with lactoferrin, in combination with vitamin A, vitamin E and fish oil(eicosapentaenoic acid and docosahexaenoic acid) is found in the prior art, nor is the use of this formulation as an adjuvant for preserving the health of the precorneal film and / or the eye surface.

Description

technical field [0001] The present invention belongs to the field of medicine, in particular to the field of ophthalmology, in which it is the formulation of blueberry extract for oral administration to adults as an adjuvant for maintaining the health of the precorneal tear film. Background technique [0002] The surface of the eyeball and the various mechanisms that keep it in optimal condition are complex. Anatomically, the surface of the eye contains an epithelium of the mucosa between the upper and lower eyelids, in the interior between their edges. The primary function of the ocular surface is to provide clear vision while maintaining comfort and a suitable microbial flora. The ocular surface must be covered with a stable precorneal tear film over the atmospherically exposed ocular surface, as "Important concepts for treating eye surface and tear disorders," Am J Ophthalmol. 1997; 124:825-835. [0003] As outlined in "Important concepts for treating eye surface and te...

AI Technical Summary

Problems solved by technology

However, the use of blueberry extracts in combination with lactoferrin and their combination with vitamin A, vitamin E and fish oils (eicosapentaenoic acid and docosahexaenoic acid) has not been previously described in the prior art. Formulations for oral administration in combination, nor their use as adjuvants for maintaining the health of the precorneal tear film