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Package instrument for obtaining sperms from seminiferous tubule in removed testicular tissue and method

A technology of seminiferous tubules and tissues, applied in biochemical equipment and methods, germ cells, animal cells, etc., can solve problems such as poor motility, sperm damage, and insufficient acrosome reaction, so as to reduce the economic burden of patients, Avoid re-trauma, good fixation effect

Pending Publication Date: 2020-09-29
MATERNAL & CHILD HEALTH CARE HOSPITAL OF SHANDONG PROVINCE SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The above-mentioned patent documents are provided with multi-needle scraping needles. The disadvantage is that the tips of these scraping needles are very easy to cause damage to sperm, and the sperm in the testis are not mature enough, which can be reflected in the incomplete nuclear condensation and mobility. Poor, lack of acrosome reaction, the sperm at this time is easily damaged by external stimuli and located in the acrosome area of ​​the head, which will have adverse effects on the fertilization of the embryo, the development of the subsequent embryo and pregnancy

Method used

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  • Package instrument for obtaining sperms from seminiferous tubule in removed testicular tissue and method
  • Package instrument for obtaining sperms from seminiferous tubule in removed testicular tissue and method
  • Package instrument for obtaining sperms from seminiferous tubule in removed testicular tissue and method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] A set tool for extracting sperm from the extracted testicular tissue, mainly including: a fixing device and a pulling device;

[0055] The fixing device 1 includes: a fixing rod 101, a first connecting rod 102, a second connecting rod 103, and a fixing frame 104;

[0056] The bottom of the fixed rod 101 is detachable, connected with the first connecting rod 102; the second connecting rod 103 is welded below the first connecting rod 102, and the second connecting rod 103 is welded with the fixed frame 104; the fixed frame 104 is a triangular design; the fixed frame 104 is an equilateral triangular frame; fixed frame 104 is a medical antibacterial transparent organic glass material; the second connecting rod 103 includes three claw-shaped rods stretched out; the angle between adjacent claw-shaped rods is the same; the lower ends of the claw-shaped rods are respectively connected to The three end points of the fixing frame 104 are connected;

[0057] The fixing device 1 a...

Embodiment 2

[0071] The difference from Embodiment 1 is that the upper part of the second connecting rod 102 is also threaded with bolts, so as to better fix the second connecting rod 102 . All the other are identical with embodiment 1.

Embodiment 3

[0073] The difference from Embodiment 1 is that the tissue picker 203 is in a "U" shape, and the rest are the same as Embodiment 1. The end of the tissue remover 203 is a non-point structure; the end of the tissue remover 203 is a smooth arc structure.

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Abstract

The invention belongs to the technical field of instruments for reproductive medicine, and particularly relates to a package instrument capable of improving sperm-obtaining efficiency. The package instrument mainly comprises a fixing device and a poking device; the fixing device comprises a fixing rod, a first connection rod, a second connection rod and a fixing frame; the first connection rod isdetachably connected with the lower portion of the fixing rod, a second connection rod is connected with the lower portion of the first connection rod, and the second connection rod is connected withthe fixing frame; the poking device comprises a tissue poking rod, a third connection rod and a tissue poking device; and the third connection rod is detachably connected with the lower portion of thetissue poking rod, and the tissue poking device is connected with the lower portion of the third connection rod. The package instrument capable of improving the sperm-obtaining efficiency has the beneficial effects that by using the package instrument, testicular tissue can be well fixed, and damage to sperms in traditional sperm-obtaining operation processes and the like is avoided at the same time, so that the probability of success of sperm-obtaining operation is significantly increased.

Description

technical field [0001] The invention belongs to the technical field of reproductive medicine tools, and in particular relates to a tool set for separating sperm from seminiferous tubules in extracted testicular tissue, and also relates to a method for using the tool set. Background technique [0002] In clinical practice, azoospermia accounts for 10%-15% of male infertility patients, and about 50.0% of azoospermia is caused by non-obstructive factors. Non-obstructive azoospermia (NOA) is a common and intractable disease in male reproductive clinics. Its etiological mechanism is complex and changeable, which is caused by the dysfunction of testicular spermatogenesis caused by various factors. For this part of NOA patients, there are still some seminiferous foci in the seminiferous tubules in the testis, and spermatozoa may be obtained from these seminiferous foci. Clinically, reproductive andrologists can use open testicular biopsy (TESE) or microtesticular sperm extraction ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/00C12N5/076
CPCC12M47/04C12N5/061
Inventor 伍玲园张亮杨慧军吕雪梅董云玲陶国振范媛媛雷丽君刘皎婧盛连兵董芳地顾光燕于娜
Owner MATERNAL & CHILD HEALTH CARE HOSPITAL OF SHANDONG PROVINCE SHANDONG UNIV
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