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Application of eight-treasure pills in preparation of medicine for preventing and treating liver cancer

A technique for treating liver cancer, Babao Dan, applied in the field of traditional Chinese medicine

Pending Publication Date: 2020-10-02
NANJING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing technology suggests that its therapeutic effect may be related to its anti-inflammatory effect

Method used

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  • Application of eight-treasure pills in preparation of medicine for preventing and treating liver cancer
  • Application of eight-treasure pills in preparation of medicine for preventing and treating liver cancer
  • Application of eight-treasure pills in preparation of medicine for preventing and treating liver cancer

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Embodiment Construction

[0025] The term "JAK / STAT signaling pathway" is a common pathway of many cytokine signal transduction, widely involved in cell proliferation, differentiation, apoptosis and inflammation, etc. way of regulation. The STAT protein family includes STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6.

[0026] The term "STAT3" belongs to a member of the STAT family and is a regulatory element downstream of the JAK / STAT signaling pathway. When activated by phosphorylation, it forms a dimer transcription factor and enters the nucleus to activate the transcription of downstream target genes.

[0027] The medicine of the present invention can be produced by methods well known in the art, such as conventional Chinese medicine preparations, including pills, powders, ointments, pills and the like. Preferably, the traditional Chinese medicine preparation is selected as a pill.

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Abstract

The invention relates to the field of traditional Chinese medicines, in particular to an application of eight-treasure pills in preparation of a medicine for preventing and treating the liver cancer.The invention discloses prevention and treatment effects of the eight-treasure pills on solid tumor and advanced ascites tumor of the liver cancer. The mechanism of action is that anti-tumor cell proliferation is generated by inhibiting activation of a JAK / STAT signaling pathway. It is further defined that the effect is to inhibit a tumor promotion inflammatory pathway by inhibiting phosphorylation of STAT3. Lymphocytes in ascites can be activated to secrete and express IFN-gamma, the survival time of tumor-bearing mice is remarkably prolonged, and the application prospect of tumor drugs is great.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to the application of Babao Dan in the preparation of drugs for preventing and treating liver cancer. Background technique [0002] Babao Dan is a nationally confidential variety of traditional Chinese medicine. It has the effects of clearing away dampness and heat, promoting blood circulation and detoxification, removing jaundice and relieving pain. It is suitable for fever, jaundice, yellow and red urine, nausea and vomiting, anorexia, hypochondriac pain and abdominal distension, yellow and greasy tongue coating or thick and dry white tongue coating, or burning and tingling of the urethra caused by damp-heat betting, lower abdominal pain, and Infectious viral hepatitis, acute cholecystitis, acute urinary tract infection, etc. are seen in those with the above syndromes. Accordingly, the prior art discloses the therapeutic effect of Babao Dan on the hepatobiliary and uri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P35/00A61P35/04A61K35/413A61K35/583A61K35/32A61K35/618A61K35/55
CPCA61K36/258A61K35/413A61K35/583A61K35/32A61K35/618A61K35/55A61P35/00A61P35/04A61K2300/00
Inventor 魏继武吴俊华陈安仙沃冠群王士群
Owner NANJING UNIV
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