Pharmaceutical composition for preventing and treating myocardial ischemia and preparation method and application thereof

A technique for myocardial ischemia and acute myocardial ischemia, applied in drug combinations, pharmaceutical formulations, cardiovascular system diseases, etc.

Active Publication Date: 2020-10-13
WENZHOU PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in clinical practice, the above drugs still have various limitations f

Method used

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  • Pharmaceutical composition for preventing and treating myocardial ischemia and preparation method and application thereof
  • Pharmaceutical composition for preventing and treating myocardial ischemia and preparation method and application thereof
  • Pharmaceutical composition for preventing and treating myocardial ischemia and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 : Preparation of Secnidazole Solid Lipid Microparticles

[0022] Secnidazole-loaded solid lipid particles (SLM) were prepared by anti-solvent precipitation.

[0023] Preparation method: Add 25 mg of secnidazole and 100 mg of glyceryl palmitate PrecirolATO5 to 100 ml of isopropanol, and heat to 45°C until the solid is completely dissolved. At the same time, 100 mL of deionized water was heated to the same temperature. The organic solution was then injected into water using a syringe equipped with a 251 / 2G gauge needle under constant stirring at 500 rpm. Stirring was continued for 15 minutes at room temperature. The pH of the resulting slurry was adjusted to 1.5 by adding 0.1M hydrochloric acid to flocculate the precipitated particles. Put the aggregated particles in the Centrific TM Centrifuge at maximum speed for 20 minutes. The supernatant was then removed, and the pellet was washed twice with deionized water. Using a freeze dryer overnight, the precip...

Embodiment 2

[0024] Example 2 : Preparation of Secnidazole Solid Lipid Microparticles

[0025] Secnidazole-loaded solid lipid particles (SLM) were prepared by anti-solvent precipitation.

[0026] Preparation method: Add 45 mg of secnidazole and 150 mg of glyceryl behenate into 100 ml of isopropanol, and heat to 70°C until the solid is completely dissolved. At the same time, 100 mL of deionized water was heated to the same temperature. The organic solution was then injected into water using a syringe equipped with a 251 / 2G gauge needle under constant stirring at 500 rpm. Stirring was continued for 25 minutes at room temperature. The pH of the resulting slurry was adjusted to 2.0 by adding 0.1M hydrochloric acid to flocculate the precipitated particles. Put the aggregated particles in the Centrific TM Centrifuge at maximum speed for 25 minutes. The supernatant was then removed, and the pellet was washed twice with deionized water. Using a freeze dryer overnight, the precipitated part...

Embodiment 3

[0027] Example 3 : Preparation of Secnidazole Solid Lipid Microparticles

[0028] Secnidazole-loaded solid lipid particles (SLM) were prepared by anti-solvent precipitation.

[0029] Preparation method: Add 45 mg of secnidazole and 150 mg of glyceryl caprylate to 100 ml of isopropanol, and heat to 55°C until the solid is completely dissolved. At the same time, 100 mL of deionized water was heated to the same temperature. The organic solution was then injected into water using a syringe equipped with a 251 / 2G gauge needle under constant stirring at 500 rpm. Stirring was continued for 15 minutes at room temperature. The pH of the resulting slurry was adjusted to 1.5 by adding 0.1M hydrochloric acid to flocculate the precipitated particles. Put the aggregated particles in the Centrific TM Centrifuge at maximum speed for 20 minutes. The supernatant was then removed, and the pellet was washed twice with deionized water. Using a freeze dryer overnight, the precipitated parti...

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PUM

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Abstract

The invention discloses an application of secnidazole to preparation of drugs for treating and/or preventing myocardial ischemia. The invention further discloses a pharmaceutical composition for treating and/or preventing the myocardial ischemia. The pharmaceutical composition comprises the secnidazole and a pharmaceutically acceptable excipient. A pharmacodynamic experiment result shows that thesecnidazole has a protective effect on an experimental myocardial ischemic injury, can significantly reduce the area of myocardial infarction, reduce the degree of myocardial damage, reduce the MDA content in serum and increase the content of active SOD, and can effectively resist acute myocardial ischemia and protect myocardium, so as to improve the symptoms of the myocardial ischemia.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a pharmaceutical composition for preventing and treating myocardial ischemia, a preparation method and application thereof. Background technique [0002] Myocardial ischemia refers to a pathological state in which the blood perfusion of the heart is reduced, resulting in reduced oxygen supply to the heart, abnormal myocardial energy metabolism, and failure to support the normal work of the heart. According to the nomenclature and diagnostic criteria of "ischemic heart disease" published by the World Health Organization, myocardial ischemia is divided into the following four categories: angina pectoris, myocardial infarction, ischemic cardiomyopathy, and sudden death. Clinically, acute myocardial ischemia mainly manifests as acute angina pectoris, acute myocardial infarction and other symptoms, and severe cases may endanger the lives of patients. Among them, acute myocardial in...

Claims

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Application Information

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IPC IPC(8): A61K31/4164A61K31/4422A61P9/10A61K9/16A61K47/14
CPCA61K9/1617A61K31/4164A61K31/4422A61P9/10A61K2300/00
Inventor 姜文兵
Owner WENZHOU PEOPLES HOSPITAL
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