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Diagnosis of mild or severe periodontitis

A periodontitis, severe technology applied in the field of oral care, which can solve the problems that consumers cannot perform

Pending Publication Date: 2020-11-17
KONINKLJIJKE PHILIPS NV
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

However, the available methods for this assessment involve a labor-intensive process that is not routinely performed by dentists on every patient and / or visit, and is not available to consumers (self-diagnosis)

Method used

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  • Diagnosis of mild or severe periodontitis
  • Diagnosis of mild or severe periodontitis
  • Diagnosis of mild or severe periodontitis

Examples

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Embodiment Construction

[0026] In a general sense, the present invention is based on the sensible insight that as few as three proteins in saliva samples of human patients with periodontitis can serve as biomarkers for classifying said periodontitis into two Any of two categories, one with severe periodontitis and the other with mild or moderate (i.e., not severe, above and below, the term "mild periodontitis" will include moderate periodontitis Zhou Yan, unless otherwise indicated). The latter category is hereinafter collectively referred to as mild periodontitis.

[0027] Identified protein biomarkers in at least two combinations with hemoglobin-beta (Hb-β), hemoglobin-delta (Hb-delta), S100 calcium binding protein A8 (S100A8) and S100 calcium binding protein A9 (S100A9) is pyruvate kinase (PK).

[0028] Optionally, the subject's age can be included as an additional marker.

[0029] Pyruvate kinase (PK) catalyzes the last step in glycolysis. There are four tissue-specific isozymes of pyruvate k...

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Abstract

Disclosed is an in vitro method for assessing whether a human patient suffering from periodontitis has mild periodontitis or advanced periodontitis. The method is based on the insight to determine a selection of three bio marker proteins. Accordingly, in a sample of saliva a patient suffering from periodontitis, the concentrations are measured of the proteins Pyruvate Kinase (PK) and at least twoof Haemoglobin-beta (Hb-beta), Haemoglobin-delta (Hb-delta), S100 calcium-binding protein A8 (S100A8) and S100 calcium-binding protein A9 (S100A9). Based on the concentrations as measured, a value reflecting the joint concentrations for said proteins is determined. The value is compared with a threshold value reflecting in the same manner the joint concentrations associated with advanced periodontitis. The comparison allows assessing whether the testing value is indicative of the presence of advanced periodontitis or of mild periodontitis in the patient. Thereby, typically, a testing value reflecting a joint concentration below the joint concentration reflected by the threshold value is indicative for mild periodontitis in the patient, and a testing value reflecting a joint concentration at or above the joint concentration reflected by the threshold value, is indicative for advanced periodontitis in the patient.

Description

technical field [0001] The present invention belongs to the field of oral care and relates to saliva-based diagnosis of periodontal disease. In particular, the present invention relates to kits and methods for distinguishing mild from severe periodontitis. Background technique [0002] Inflammation of the gums, or gingivitis, is a non-destructive periodontal disease primarily caused by the adhesion of dental plaque, or plaque, to the tooth surface, which triggers an inflammatory response in the surrounding tissues. Gingivitis is a reversible infection and inflammation of the gum tissue and can be resolved with proper oral hygiene measures and dental professional intervention. If not detected or addressed, gingivitis often results in inflammation of the tissue surrounding the tooth (i.e., the periodontium), a condition defined as periodontitis, which leads to tissue destruction and loss of alveolar bone and eventually tooth loss . During the development of gum disease, the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/6803G01N33/6893G01N2333/47G01N2800/18B01L3/502707B01L3/502715C12N9/1205C12Y207/0104G01N2333/4701
Inventor G·库伊杰曼A·H·里迈勒C·格拉斯M·K·J·德加格I·L·C·察柏尔M·M·格兰特P·普雷肖J·J·泰勒M·A·范哈特斯坎普
Owner KONINKLJIJKE PHILIPS NV
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