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Diagnostics of mild or advanced periodontitis

A periodontitis, severe technology, applied in the field of oral care, can solve problems such as impossible implementation of consumers

Pending Publication Date: 2021-02-02
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, existing methods of performing this assessment involve a labor-intensive process that is not routinely performed by dentists on each patient and / or visit, and that is impossible for consumers to perform (self-diagnosis)

Method used

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  • Diagnostics of mild or advanced periodontitis
  • Diagnostics of mild or advanced periodontitis
  • Diagnostics of mild or advanced periodontitis

Examples

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Embodiment Construction

[0048] In summary, the present invention is based on the sensible insight that in saliva samples of human patients with periodontitis, only two proteins can be used as biomarkers for classifying periodontitis is either of two categories, one of severe periodontitis and the other of mild or moderate (i.e., non-severe, unless otherwise specified, the term "mild periodontitis" above and below ” would include moderate periodontitis). The latter category is hereinafter collectively referred to as mild periodontitis.

[0049] The protein biomarkers identified were pyruvate kinase (PK), matrix metalloproteinase-9 (MMP9), S100 calcium binding protein A8 (S100A8), hemoglobin subunit beta (Hb-β), and S100 calcium binding protein A9 (S100A9 ). According to the invention, the following combinations of these proteins are used for the diagnosis of gingivitis:

[0050] Pyruvate kinase (PK) and at least one of matrix metalloproteinase-9 (MMP9), S100 calcium binding protein A8 (S100A8), and...

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Abstract

Disclosed is an in vitro method for assessing whether a human patient suffering from periodontitis has mild periodontitis or advanced periodontitis. The method is based on the insight to determine a selection of two biomarker proteins. Accordingly, in a sample of saliva a patient suffering from periodontitis, the concentrations are measured of the proteins Pyruvate Kinase (PK) and at least one ofMatrix metalloproteinase-9 (MMP9), S100 calcium-binding protein A8 (S100A8), and Hemoglobin subunit beta (Hb-beta); or of the proteins Matrix metalloproteinase-9 (MMP9) and at least one of S 100 calcium-binding protein A8 (S100A8) and S100 calcium-binding protein A9 (S100A9). Based on the concentrations as measured, a value is determined reflecting the joint concentrations for said proteins. Thisvalue is compared with a threshold value reflecting in the same manner the joint concentrations associated with advanced periodontitis. The comparison allows assessing whether the testing value is indicative of the presence of advanced periodontitis or of mild periodontitis in said patient. Thereby, typically, a testing value reflecting a joint concentration below the joint concentration reflectedby the threshold value is indicative for mild periodontitis in said patient, and a testing value reflecting a joint concentration at or above the joint concentration reflected by the threshold value,is indicative for advanced periodontitis in said patient.

Description

technical field [0001] The present invention is in the field of oral care and relates to saliva-based diagnosis of periodontal disease. In particular, the present invention relates to a kit and method for distinguishing mild periodontitis from severe periodontitis. Background technique [0002] Gingivitis or gingivitis is a non-destructive periodontal disease mainly caused by dental bacterial biofilm, or plaque, attached to the tooth surface, which triggers an inflammatory response in the surrounding tissue. Gingivitis is a reversible infection and inflammation of the gum tissue that can be resolved with proper oral hygiene measures and dental professional intervention. If not detected or addressed, gingivitis typically results in inflammation of the tissues surrounding the teeth, known as the periodontium, a condition defined as periodontitis leading to tissue destruction and loss of alveolar bone, and ultimately tooth loss. As gum disease develops, there are often clinic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2333/912G01N2800/18G01N2333/96494
Inventor G·库伊杰曼A·H·里迈勒C·格拉斯M·K·J·德加格I·L·C·察柏尔M·M·格兰特P·普雷肖J·泰勒M·A·范哈特斯坎普
Owner KONINKLJIJKE PHILIPS NV
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