Black ginseng extract and black ginseng quick release mini-pill for treating renal interstitial fibrosis, and application of black ginseng extract and black ginseng quick release mini-pill

Abstract

The invention provides a black ginseng extract and a black ginseng quick release mini-pill for treating renal interstitial fibrosis, and application of the black ginseng extract and the black ginsengquick release mini-pill, and belongs to the technical field of medicines. The black ginseng extract efficiently extracts ginseng saponin Rg3, Rg5 and Rk1 from the black ginseng by an ultrasonic extraction method. The invention also provides a black ginseng quick release mini-pill, which comprises the following ingredients in parts by weight: 15-35% of black ginseng extract, 25-47% of microcrystalline cellulose, 23-26% of lactose, 5-8% of crosslinked carboxymethyl starch sodium, 5-8% of low-substituted hydroxypropyl cellulose and the balance of ethyl alcohol aqueous solution of which the volumefraction is 50-65%. In vivo and vitro experiment investigates a medicine efficacy function and a pharmacology mechanism of the black ginseng extract and the black ginseng quick release mini-pill forintervening in the renal interstitial fibrosis so as to indicate that the black ginseng extract or the black ginseng quick release mini-pill has potential for preparing a medicine for treating the renal interstitial fibrosis.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a black ginseng extract for treating renal interstitial fibrosis, black ginseng quick-release pellets and applications thereof. Background technique [0002] Chronic kidney disease (CKD) is a serious clinical problem. Currently, renal fibrosis, especially renal interstitial fibrosis (Renal interstitial fibrosis, RIF) is recognized as a common disease in end-stage renal disease (ESRD). Pathway, in which the development of renal fibrosis is significantly related to the occurrence of CKD. RIF is a progressive process of constant changes, characterized by the continuous generation of activated myofibroblasts (myofibroblast) and excess extracellular matrix (Extracellular matrix, ECM) in the renal tubules, and activated myofibroblasts are considered to be the pathogenesis of RIF main factor. The origin of activated myofibroblasts is still unclear, and there is evidence ...

AI Technical Summary

Problems solved by technology

The extraction method of black ginseng is in the local standard black ginseng of Jilin Province (DB 22 / T 2758-2017), and the preparation method of the test solution under the determination method of ginseng content in the Chinese Pharmacopoeia is adopted. This method takes a long time for extraction and separation. There are many steps and the concentration gradient of the target components inside and outside the matrix is ​​relatively large, so the extraction of saponins is not thorough enough

The reflux extraction method commonly used in traditional Chinese medicine uses the solution to be in a boiling state to strengthen the disturbance between the solution and the matrix and reduce the diffusion resistance of the fluid film on the surface of the matrix. However, this method is not conducive to the further dissolution of components due to the lack of a concentration gradient in the solution at a certain stage of extraction. , when using this method to extract black ginseng, the total content of rare ginsenosides Rg3, Rg5 and Rk1 is low

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