Treatment of sepsis and septic shock

A technology for septic shock and sepsis, applied in the field of septic shock, sepsis, acute respiratory distress syndrome and severe sepsis, can solve neurological and cognitive sequelae and other problems, and achieve improvement of clinical signs and symptoms, Reasonable efficacy and improved hemodynamic parameters

Pending Publication Date: 2020-11-20
COMBIOXIN SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, chronic tissue hypoperfusion may lead to long-term neurological and cognitive sequelae

Method used

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  • Treatment of sepsis and septic shock
  • Treatment of sepsis and septic shock
  • Treatment of sepsis and septic shock

Examples

Experimental program
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Effect test

example 1

[0141] Treatment of sepsis and septic shock in severely infected patients

[0142] In a subsequently reported study, a highly preferred mixture of empty liposomes of the present invention (designated CAL02) was administered intravenously (IV) as an adjunct to standard antibiotic therapy in severe Patients admitted to the intensive care unit (ICU) with community-acquired pneumonia (CAP). Said highly preferred inventive mixture of empty liposomes (CAL02) consists of a 1:1 (weight / weight-w / w) mixture of said first empty liposomes and said second liposomes, wherein The first empty liposome was composed of sphingomyelin and cholesterol in a 1:1 weight ratio (1:1 w / w; molar ratio 35:65), and the second empty liposome was composed of sphingomyelin only.

[0143] In addition to standard-of-care antibiotic therapy (Mandel et al., CID 2007:44(Suppl 2), S27-S72), each patient received two infusions of CAL02 or placebo (physiological 0.9% NaCl solution) with intervals of 24 hours or 48 ...

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Abstract

The present invention relates to a composition comprising a mixture of empty liposomes, wherein said mixture of empty liposomes comprises (a) a first empty liposome comprising cholesterol, wherein theamount of cholesterol is at least 30% (weight per weight); and (b) a second empty liposome comprising sphingomyelin, for use in the treatment of sepsis, severe sepsis, septic shock, or prolonged andsevere hypotension, preferably persistent hypotension, for use in the treatment of hypotension, preferably said persistent hypotension, in septic shock, sepsis, severe sepsis, acute respiratory distress syndrome or acute lung injury, or for use in the treatment of toxic shock syndrome in an animal, preferably in a human.

Description

[0001] The present invention relates to a composition comprising a mixture of empty liposomes, wherein the mixture of empty liposomes comprises: (a) a first empty liposome comprising cholesterol, wherein the amount of cholesterol is at least 30% (weight / weight); and (b) a second empty liposome comprising sphingomyelin, said composition being used to treat sepsis, severe sepsis, septic shock or chronic and severe hypotension in an animal, preferably a human , preferably persistent hypotension, for the treatment of hypotension, preferably persistent hypotension, in animals, preferably humans, in septic shock, sepsis, severe sepsis, acute respiratory distress syndrome or acute lung injury, or for Toxic shock syndrome in animals, preferably humans, is treated. In particular, the present invention relates to compositions for use in the treatment of sepsis or septic shock in animals, preferably humans. Background technique [0002] Sepsis is a potentially life-threatening organ dys...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/28A61K9/127A61K31/575A61K31/688A61P31/00
CPCA61K9/127A61K31/575A61K31/688A61K47/28A61P31/00A61K9/0019Y02A50/30A61K2300/00
Inventor S·阿泽雷多·达·西尔维拉·拉雅尤尼亚斯F·拉雅尤尼亚斯
Owner COMBIOXIN SA
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