Oral care product for resisting helicobacter pylori

An anti-Helicobacter pylori and oral care technology, applied in the field of daily chemicals, can solve problems such as repeated infection, incurable disease, repeated Hp infection, etc., and achieve a significant therapeutic effect

Inactive Publication Date: 2020-12-04

福州比格艾普科技有限公司

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AI-Extracted Technical Summary

Problems solved by technology

[0005] Hp in the oral cavity can be transmitted through saliva, and can also repeatedly infect the stomach. Therefore, oral transmission can be carried out when the amount of Hp in the oral cavi...

Method used

In summary, the oral care solution made by Radix Astragali, Forsythia, Radix Scutellariae Radix, Radix Glycyrrhizae, Peppermint and lysozyme composition has synergistic effect on suppressing oral cavit...

Abstract

The invention discloses a composition for resisting helicobacter pylori, and belongs to the technical field of daily chemical products. The composition comprises astragalus membranaceus, forsythia suspensa, scutellaria baicalensis, licorice roots, mint and lysozyme. The invention further discloses a method for making the composition into an oral care product. By using the oral care product prepared by the invention, 95% of oral Hp detection results of helicobacter pylori patients can be converted from positive to negative within 14 days, and the oral care product has a remarkable treatment effect.

Application Domain

Cosmetic preparationsToilet preparations +5

Technology Topic

LysozymeScutellaria baicalensis +9

Image

Examples

Experimental program(3)
Comparison scheme(7)
Effect test(1)

Example Embodiment

[0036]Example 1

[0037](1) Extraction: Mix 15g of Astragalus, 5g of Forsythia, 10g of Scutellaria, 4g of licorice, powdered to 20 mesh, mix with 1g of mint, add 175g of water with total mass, cook for 2h at 80℃, filter to obtain filtrate;

[0038](2) Concentration: Concentrate the filtrate under reduced pressure to a relative density of 1.2 and a water content of 10% to obtain a concentrated solution;

[0039](3) Drying: spray drying the concentrated liquid with an inlet temperature of 120°C and an outlet temperature of 50°C to form a dry powder by spraying;

[0040](4) Mixing: mix the dry powder with 1g of lysozyme to obtain the oral care water-soluble powder for use;

[0041]Add 105g of water to dissolve the oral care water-soluble powder to prepare an oral care liquid for use;

[0042]50 volunteers: patients with chronic gastritis or peptic ulcer confirmed by gastroscopy, no history of antibiotic treatment in the past six months, no oral cleansing treatment in the past year, and the urease test of dental bacteria was positive.

[0043]After getting up, rinse the mouth with the above oral care liquid every 4 hours. The oral care liquid needs to be fully infiltrated in the oral cavity, and the oral care solution stays in the oral cavity for more than 30s. Check the user's oral cavity with urease test paper every 7 days Helicobacter pylori status; select different parts of the oral cavity for 3 times of dental plaque detection, if one is positive, the result is recorded as positive, otherwise it is negative. The results are shown in Table 1.

Example Embodiment

[0044]Example 2

[0045](1) Extraction: mix 25g of Astragalus, 15g of Forsythia, 20g of Scutellaria, 8g of licorice, powdered to 60 mesh, mix with 5g of mint, add 1095g of water with total mass, cook at 100°C for 4h, filter to obtain filtrate;

[0046](2) Concentration: Concentrate the filtrate under reduced pressure to a relative density of 1.5 and a water content of 20% to obtain a concentrated solution;

[0047](3) Drying: spray drying the concentrated liquid with an inlet temperature of 140°C and an outlet temperature of 80°C to form a dry powder by spraying;

[0048](4) Mixing: Mix the dry powder with 2g of lysozyme to obtain oral care water-soluble powder for use;

[0049]Add the oral care water-soluble powder to 219g of water to dissolve it to prepare an oral care liquid for use;

[0050]50 volunteers: patients with chronic gastritis or peptic ulcer confirmed by gastroscopy, no history of antibiotic treatment in the past six months, no oral cleaning treatment in the past one year, and the test of dental bacteria urease was positive.

[0051]After getting up, rinse the mouth with the above oral care liquid every 8 hours. The oral care liquid needs to be fully infiltrated in the oral cavity, and the oral care solution stays in the oral cavity for more than 30 seconds, and the user’s oral cavity is tested with a urease test paper every 7 days Helicobacter pylori status; select different parts of the oral cavity for three times of dental plaque detection, if one is positive, the result is recorded as positive, otherwise it is negative. The results are shown in Table 1.

Example Embodiment

[0052]Example 3

[0053](1) Extraction: Mix 20g of Astragalus, 10g of Forsythia, 15g of Astragalus, 6g of licorice, powdered to 30 mesh, mix with 3g of mint, add 540g of water, cook at 90°C for 3h, filter to obtain filtrate;

[0054](2) Concentration: Concentrate the filtrate under reduced pressure to a relative density of 1.3 and a water content of 15% to obtain a concentrated solution;

[0055](3) Drying: spray drying the concentrated liquid with an inlet temperature of 130°C and an outlet temperature of 65°C, spray to form a dry powder;

[0056](4) Mixing: the dry powder is mixed with 1.5 g of lysozyme to obtain a mixed powder to obtain an oral care water-soluble powder.

[0057]Add the oral care water-soluble powder to 162g of water to dissolve it to prepare an oral care liquid for use;

[0058]50 volunteers: patients with chronic gastritis or peptic ulcer confirmed by gastroscopy, no history of antibiotic treatment in the past six months, no oral cleaning treatment in the past one year, and the test of dental bacteria urease was positive.

[0059]After getting up, rinse the mouth with the above oral care liquid every 6 hours. The oral care liquid needs to be fully infiltrated in the oral cavity, and the oral care solution stays in the oral cavity for more than 30 seconds. Check the user's oral cavity with urease test paper every 7 days Helicobacter pylori status; select different parts of the oral cavity for 3 times of dental plaque detection, if one is positive, the result is recorded as positive, otherwise it is negative. The results are shown in Table 1.

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Description & Claims & Application Information

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Classification and recommendation of technical efficacy words

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Oral care product for resisting helicobacter pylori

An anti-Helicobacter pylori and oral care technology, applied in the field of daily chemicals, can solve problems such as repeated infection, incurable disease, repeated Hp infection, etc., and achieve a significant therapeutic effect

AI-Extracted Technical Summary

Problems solved by technology

Method used

Abstract

Image

Examples

Example Embodiment

Example Embodiment

Example Embodiment

PUM

Description & Claims & Application Information

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