Application of phosphatidylserine in preparation of medicines for treating inflammatory bowel diseases

A technology of phosphatidylserine and inflammatory bowel disease, applied in the field of application of phosphatidylserine in the preparation of drugs for treating inflammatory bowel disease, achieving significant curative effect, inhibiting adhesion and infiltration

Pending Publication Date: 2020-12-11
JIANGSU TARGET BIOMEDICINE RES INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is a lack of application of phosphatidylserine i

Method used

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  • Application of phosphatidylserine in preparation of medicines for treating inflammatory bowel diseases
  • Application of phosphatidylserine in preparation of medicines for treating inflammatory bowel diseases
  • Application of phosphatidylserine in preparation of medicines for treating inflammatory bowel diseases

Examples

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Embodiment 1

[0048] The application of a kind of phosphatidylserine of the present invention in the preparation of medicine for treating inflammatory bowel disease is the medicine targeting the effect of phosphatidylserine in inflammatory bowel disease.

[0049] In inflammatory bowel disease, the phosphatidylserine of vascular endothelial cells is turned from the inner membrane to the outer membrane, and the everted phosphatidylserine can be used as a marker of inflammatory bowel disease.

[0050] Labeled annexin A5 can trace and display the lesion location and extent of inflammatory bowel disease through phosphatidylserine in the outer membrane of cells.

[0051] Targeting the role of phosphatidylserine in inflammatory bowel disease for drug screening, screening for proteins or compounds with high affinity to phosphatidylserine.

[0052] Plays anti-inflammatory effects by binding to phosphatidylserine, inhibiting inflammatory cell infiltration, and blocking immune cell recruitment in the ...

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Abstract

The invention discloses an application of phosphatidylserine in preparation of medicines for treating inflammatory bowel diseases, and the medicines taking effect of the phosphatidylserine in inflammatory bowel diseases as a target. In the inflammatory bowel diseases, the phosphatidylserine of vascular endothelial cells is exposed to an extracellular membrane from an intracellular membrane. The exposed phosphatidylserine can be used as a marker for the inflammatory bowel diseases and can be used for screening medicines for treating the inflammatory bowel diseases. According to the invention, Annexin A5 is determined to have a remarkable curative effect in treatment of the inflammatory bowel diseases. The Annexin A5 is found to be specifically combined with capillaries enriched in intestinal mucosa through PS and to inhibit adhesion and infiltration of inflammatory cells to achieve the anti-inflammatory effect for the first time.

Description

technical field [0001] The invention relates to the technical field of biochemistry, in particular to the application of phosphatidylserine in the preparation of medicines for treating inflammatory bowel disease. Background technique [0002] Annexin A5 has multiple functions in vivo, such as anti-tumor and anti-coagulation. Anti-inflammation is also an important function. Annexin A5 can interfere with the recruitment and activation of monocytes in inflammatory lesions to reduce plaque inflammation in lesions; Annexin A5 can prevent it from interacting with inflammatory cells by binding to phosphatidylserine (PS). Contact, reduces the recruitment of inflammatory cells and reduces the inflammatory response. [0003] Inflammatory bowel disease (IBD) is a chronic, easily relapsing disease, including Crohn's disease (CD) and ulcerative colitis (UC), clinically often manifested as abdominal pain, diarrhea, blood in the stool, anemia, and weight loss, etc. Greatly affect the qua...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K38/17A61P1/00A61P29/00A61P1/04
CPCA61K45/00A61K38/1709A61P1/00A61P29/00A61P1/04A61K31/685
Inventor 华子春王欣然宋露露霍利娜张学瑞
Owner JIANGSU TARGET BIOMEDICINE RES INST
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