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Organ chip, epithelial/endothelial barrier model device, and manufacturing method of organ chip and epithelial/endothelial barrier model device

An organ chip and device technology, applied in the epithelial/endothelial barrier model device and its production, in the field of organ chips, can solve the problems of microfluidic channel blockage, cell survival rate, organ chip cell seeding density uncontrollable, etc., and achieve a controllable cell seeding density control, not easy to block the flow channel, and evenly distribute the cells

Inactive Publication Date: 2020-12-15
SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The present invention aims to solve the technical problems of uncontrollable seeding density of organ chip cells, blockage of microfluidic channels and low cell survival rate in the prior art

Method used

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  • Organ chip, epithelial/endothelial barrier model device, and manufacturing method of organ chip and epithelial/endothelial barrier model device
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  • Organ chip, epithelial/endothelial barrier model device, and manufacturing method of organ chip and epithelial/endothelial barrier model device

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Embodiment Construction

[0071] The technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Apparently, the described embodiments are only some of the embodiments of this application, not all of them. Based on the embodiments in this application, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of this application.

[0072] Reference herein to "one embodiment" or "an embodiment" refers to a specific feature, structure or characteristic that may be included in at least one implementation of the present application. In the description of the present application, it should be understood that the orientation or positional relationship indicated by the terms "upper", "lower", "top", "bottom" etc. is based on the orientation or positional relationship shown in the drawings, and is only for It ...

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Abstract

The invention relates to the technical field of organ chips, in particular to an organ chip, an epithelial / endothelial barrier model device, and a manufacturing method of the organ chip and epithelial / endothelial barrier model device. The organ chip comprises a first flexible layer, a porous cell culture membrane and a second flexible layer, wherein the first flexible layer is arranged at the bottom of the porous cell culture membrane, and comprises a first culture hole, the second flexible layer is arranged at the top of the porous cell culture membrane, and comprises a second culture hole and first flow guide holes, the first culture hole and the second culture hole are used for storing a nutrient solution, and provide spaces for the growth of cells on the porous cell culture membrane, and the first flow guide holes are used for guiding the nutrient solution into the first culture hole. The organ chip provided by the invention is of an open design, and has the characteristics of controllable cell inoculation density, difficulty in flow channel blockage, and high cell survival rate.

Description

technical field [0001] The invention relates to the technical field of organ chips, in particular to an organ chip, an epithelial / endothelial barrier model device and a manufacturing method thereof. Background technique [0002] Organ chips are in vitro physiological microsystem models of human organs or tissues. Through the bionic construction of organs or tissues and the precise control of the microenvironment of cells, organ chips can better restore the real physiological functions of organs or tissues in the body. Applications such as tissue culture, pathology research, and drug screening provide a novel technology platform. [0003] Epithelial and endothelial cells play an important role in the barrier function of many organs. Arranged in successive layers, these cells control the diffusion and transport of chemicals. In drug development, it is necessary to study how to allow therapeutic agents to cross the endothelial barrier to target organs. Therefore, the constru...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M3/00C12M3/06C12M1/34
CPCC12M23/12C12M23/20C12M25/04C12M27/22C12M29/10C12M35/08C12M41/46
Inventor 毛红菊杨盼慧吴蕾关一民赵建龙
Owner SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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