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Application of dronedarone hydrochloride in preparation of anti-digestive tract tumor drug

A technology for dronedarone hydrochloride and digestive tract tumors, applied in the field of biomedicine, can solve the problems of low early diagnosis rate, poor prognosis of patients, and side effects

Inactive Publication Date: 2020-12-29
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although surgical resection and effective adjuvant treatment at the early stage of the disease have good therapeutic effects, gastric cancer is still a threat to patients due to poor prognosis and low early diagnosis rate, and radiotherapy and chemotherapy have serious side effects on the body. A major cancer of life and health

Method used

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  • Application of dronedarone hydrochloride in preparation of anti-digestive tract tumor drug
  • Application of dronedarone hydrochloride in preparation of anti-digestive tract tumor drug
  • Application of dronedarone hydrochloride in preparation of anti-digestive tract tumor drug

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Embodiment Construction

[0019] The technical solution of the present invention will be further described in detail below in conjunction with the examples, but the following examples are only used to illustrate the present invention, and should not limit the scope of the present invention.

[0020] 1. Materials

[0021] 1.1 Main reagents:

[0022] Dronedarone hydrochloride was purchased from Nantong Feiyu Biotechnology Co., Ltd., with a purity of 97%; cell culture medium was purchased from Thermo Fisher Scientific in the United States; fetal bovine serum was purchased from BD in the United States

[0023] 1.2 Main instruments and equipment:

[0024] Dry CO 2 Incubator, Shanghai Yiheng Scientific Instrument Co., Ltd.;

[0025] High-speed low-temperature centrifuge, Eppendorf, Germany;

[0026] High-content analysis imaging system In Cell Analyzer 6000, GE, USA

[0027] Inverted microscope, Carl Zeiss Jena, Germany

[0028] 96-well cell culture plate, Wuxi Nice Biotechnology Co., Ltd.

[0029] 2....

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Abstract

The invention discloses application of dronedarone hydrochloride in preparation of an anti-digestive tract tumor drug. The chemical name of dronedarone hydrochloride is N [2-butyl-3[4-[3- (dibutylamino) propoxy]phenyl]-5-benzofuran] methanesulfonamide. The application comprises the following steps: firstly, through the action of dronedarone hydrochloride on an esophageal cancer cell line, specifically evaluating the effect of dronedarone hydrochloride in an esophageal cancer in-vitro experiment. Secondly, through the action of dronedarone hydrochloride on the gastric cancer cell line, specifically evaluating the in-vitro inhibition effect of dronedarone hydrochloride on the gastric cancer cell line, and comprehensively evaluating the effect of dronedarone hydrochloride in digestive tract tumors. Results show that dronedarone hydrochloride with a proper concentration has a good inhibition effect in a digestive tract tumor cell line, and a new thought and a new basis are provided for treatment and prevention of tumors.

Description

technical field [0001] The application belongs to the field of biomedicine, and in particular relates to the application of dronedarone hydrochloride in the preparation of anti-digestive tract tumor drugs. Background technique [0002] Esophageal cancer (EC) is one of the eight most common malignant tumors in the world. According to the survey data of the World Health Organization and the International Agency for Research on Cancer (WHO / IARC), there were about 456,000 new cases of esophageal cancer in the world in 2012, accounting for all 3.2% of cancer incidence; about 400,000 deaths, accounting for 4.9% of all cancer deaths. China is a country with a high incidence of esophageal cancer and the country with the highest mortality rate of esophageal cancer. Its incidence rate ranks fifth among all types of tumors in mainland China, and its case fatality rate ranks fourth. The incidence of esophageal cancer in China shows obvious regional differences. The absolute high incide...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/343A61P1/00A61P35/00
CPCA61K31/343A61P1/00A61P35/00
Inventor 刘康栋董子钢李博赵继敏江亚南张静董子明
Owner ZHENGZHOU UNIV
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