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Alcohol-free guanidine no-clean disinfectant and preparation method thereof

A disinfectant and guanidine technology, applied in the field of disinfectant and its preparation, can solve the problems of hand skin allergy, skin damage, redness, etc., and achieve the effect of long antibacterial time, low production cost and high skin affinity

Inactive Publication Date: 2021-01-05
JIANGSU LOPALTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ethanol in alcohol is a commonly used solvent and disinfectant, which has good bactericidal properties, but the sequelae of frequent use of alcohol-containing hand sanitizers is that the skin of the hands may appear allergic, red, rough and other symptoms. Some damage to the skin

Method used

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  • Alcohol-free guanidine no-clean disinfectant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024]In this embodiment, the guanidine disinfectant is 20wt% chlorhexidine gluconate solution, the ammonium salt disinfectant is 44wt benzalkonium chloride solution, the preservative is phenoxyethanol, the emollient is glycerin, and the softener is hard Ester alcohol ether, cleaning agent is alkyl alcohol polyoxyethylene ether, solubilizer is polyethylene glycol 400.

[0025]Take 1 part of glycerin and 2 parts of stearyl alcohol ether, sequentially add 83 parts of deionized water, stir to dissolve completely, then add 10 parts of polyethylene glycol to the system, stir to dissolve completely, and then add 2.5 parts of glucose to the system Chlorhexidine acid solution and 0.4 parts of benzalkonium chloride solution, stir to dissolve completely and adjust the pH to 7.0, finally add 0.1 part of phenoxyethanol and 1 part of alkyl alcohol polyoxyethylene ether to the system, stir to completely dissolve Get the final product.

Embodiment 2

[0027]In this embodiment, the guanidine disinfectant is 20wt% polyhexamethylene biguanide solution, the ammonium salt disinfectant is 44wt benzalkonium bromide solution, the preservative is sodium benzoate, the emollient is glycerol polyoxyethylene ether, The softening agent is stearyl ether, the cleaning agent is cocamidopropyl amine oxide, and the solubilizing agent is 1,2-propylene glycol.

[0028]Take 1 part of glycerol polyoxyethylene ether and 2 parts of stearyl alcohol ether, sequentially add 81.75 parts of deionized water, stir to dissolve completely, then add 10 parts of 1,2-propylene glycol to the system, stir to dissolve completely, and then add to the system Add 3 parts of polyhexamethylene biguanide solution and 0.2 parts of benzalkonium bromide solution, stir to dissolve completely and adjust the pH to 6.5, and finally add 0.05 parts of phenoxyethanol and 2 parts of cocamidopropyl to the system The amine oxide is completely dissolved by stirring to obtain the final produc...

Embodiment 3

[0030]In this embodiment, the guanidine disinfectant is 20wt% chlorhexidine acetate solution, the ammonium salt disinfectant is 90wt laurylamine dipropylene diamine solution, the preservative is phenoxyethanol, and the emollient is glycerol polyoxyethylene. Vinyl ether and softener are stearyl alcohol ether, cleaning agent is cocamidopropyl betaine, and solubilizer is 1,2-pentanediol.

[0031]Take 3 parts of glycerol polyoxyethylene ether and 2 parts of stearyl alcohol ether, sequentially add 65.32 parts of deionized water, stir to dissolve completely, then add 22 parts of 1,2-pentanediol to the system, stir to dissolve completely, and then Add 5 parts of chlorhexidine acetate solution and 0.6 parts of laurylamine dipropylene diamine solution to the system, stir to dissolve completely and adjust the pH to 7.5, and finally add 0.08 parts of phenoxyethanol and 2 parts of coconut to the system The oleamidopropyl betaine is completely dissolved by stirring to obtain the final product.

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Abstract

The invention discloses an alcohol-free guanidine no-clean disinfectant. The alcohol-free guanidine no-clean disinfectant is prepared from a guanidine disinfectant, an ammonium salt disinfectant, a preservative, an emollient, a softener, a solubilizer, a cleaning agent and water, and the guanidine disinfectant comprises one or more of chlorhexidine acetate, chlorhexidine gluconate and polyhexamethylene biguanide; the ammonium salt disinfectant is prepared from one or more of benzalkonium chloride, benzalkonium bromide and lauryl amine dipropylene diamine; and the water comprises deionized water. The guanidine disinfectant and the ammonium salt disinfectant are selected to replace traditional disinfectant ethyl alcohol, no pungent smell exists, the skin-friendly performance is high, the problems that an alcohol disinfectant is heavy in smell, poor in skin-friendly performance and inconvenient to carry are solved while the sterilization effect is guaranteed, meanwhile, the guanidine disinfectant is high in solubility in water, wide in application range and long in antibacterial time, and the effective sterilization time of guanidine no-clean disinfection spray can be prolonged. The preparation method is simple, easy to operate and low in production cost.

Description

Technical field[0001]The invention relates to a disinfectant and a preparation method thereof, in particular to a non-alcohol guanidine no-wash disinfectant and a preparation method thereof.Background technique[0002]Since the outbreak of the novel coronavirus pneumonia, people have increasingly used disinfectant in their opponents. The use of disinfectant can effectively reduce virus transmission. The use of disinfectant includes liquid, spray, foam, etc. The disinfectant used in the spray state is called spray-type hand disinfectant. The spray type hand sanitizer is stored and transported in a liquid state, and the spray is produced by pressing when in use. The disinfectant spray has the advantages of small dosage, large area of ​​action and cost saving.[0003]Spray-type hand disinfectants are mainly composed of alcohols, disinfectants, softeners, preservatives and the like. Ethanol in alcohols is a commonly used solvent and disinfectant, which has good bactericidal properties, but ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/43A61K8/41A61K8/34A61K8/86A61Q17/00A61Q17/02A61Q19/10
CPCA61K8/416A61K8/43A61K8/345A61K8/86A61Q19/10A61Q17/005A61Q17/02
Inventor 唐泳贤石俊峰史莹飞曲婉莹
Owner JIANGSU LOPALTECH
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