The invention relates to an external preparation on the skin, which has obvious effects of inflammation reduction, itching relief and sanitization; active The components contain: rhubarb, turmeric root tuber, sublimed sulfur, baical skullcap root, radix glycyrrhizae, borneol, menthol and adrenal cortex hormone; calculated as pharmacological raw materials, the weight proportion of the active components rhubarb, turmeric root tuber, sublimed sulfur, baical skullcap root, radix glycyrrhizae, borneol and menthol are: 1 to 99 portion of rhubarb, 1 to 80 portion of turmeric root tuber, 1 to 70 portion of sublimed sulfur, 1 to 20 portion of baical skullcap root, 0.1 to 18 portion of radix glycyrrhizae, 0.1 to 10 portion of borneol, 0.1 to 10 portion of menthol and 0.1 to 10 portion adrenal cortex hormone. After smeared on the illness, the preparation has strong and quick disinfectant effect, can clean and care the skin, with good safety, little adverse reaction and low recurrence rate. In particular, when the skin is injured and a chronic disease is led, the preparation can still be used repeatedly for a long time, with obvious effect, convenience in us, and without side effect of hormones medicine.