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A kind of antibacterial composition, mouthwash and preparation method thereof

A technology for mouthwash and composition, applied in the field of oral care, can solve problems such as poor bactericidal effect, and achieve the effects of improving bacteriostatic effect, improving hydrolysis resistance and strong activity

Active Publication Date: 2021-06-22
苏州承芃和医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to improve the problem of poor bactericidal effect caused by the solubility of glyceryl monocaprylate, the application provides an antibacterial composition, mouthwash and its preparation method

Method used

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  • A kind of antibacterial composition, mouthwash and preparation method thereof
  • A kind of antibacterial composition, mouthwash and preparation method thereof
  • A kind of antibacterial composition, mouthwash and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1-6

[0040] The following will be described by taking Example 1 as an example, wherein the glyceryl monocaprylate is food grade and purchased from Jiangsu Caiwei Biotechnology Co., Ltd.; the cationic polymer polypeptide is YR-CP1, and the sequence of YR-CP1 is :

[0041]

[0042] The cyclodextrin is gamma-cyclodextrin, the CAS number is 17465-86-0; the menthol is L-menthol, the CAS number is 2216-51-5; the xanthan gum is food grade, purchased From Jinan Yuncheng Biotechnology Co., Ltd.

[0043] The preparation method of a kind of mouthwash provided in Example 1 is: according to the mass percentage of Table 1, take glyceryl monocaprylate, cyclodextrin, deionized water whose quality is 100 times of glyceryl monocaprylate (heat to 60 ℃) , Dissolve monocaprylic glyceride and cyclodextrin, stir and mix continuously in a water bath at 60°C for 30 minutes, then add cationic polymer polypeptide, menthol, glycerin, xanthan gum and the remaining deionized water, and mix to obtain mouthwa...

Embodiment 7-8

[0048] Embodiment 7-8 is the same as embodiment 6, and the difference only lies in:

Embodiment 7

[0049] Example 7, the difference is: the cationic polymer polypeptide is YR-CP2, and the sequence of YR-CP2 is:

[0050]

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Abstract

The application relates to the field of oral care, in particular to an antibacterial composition, mouthwash and a preparation method thereof. The bacteriostatic composition comprises glyceryl monocaprylate, cationic polymer polypeptide and cyclodextrin; the mass ratio of glyceryl monocaprylate, cationic polymer polypeptide and cyclodextrin is (5-6): (8-10): (40‑48). The bacteriostatic composition provided by the application not only improves the solubility and dissolution rate of the monocaprylic glyceride in water, but also significantly improves the bactericidal effect, and can also cover up the pungent smell of the monocaprylic glyceride itself. The mouthwash prepared by the present application uses glycerin and xanthan gum as a moisturizing agent, which can not only improve the moisturizing effect, but also effectively reduce the volatility of menthol, and the mouthwash has no stratification and crystallization. The preparation method of the mouthwash provided by the application can promote better inclusion of monocaprylic glyceride by cyclodextrin, and has good stability.

Description

technical field [0001] The application relates to the field of oral care, in particular to an antibacterial composition, mouthwash and a preparation method thereof. Background technique [0002] The oral cavity, which comes into contact with food every day, is a breeding ground for bacteria. Bacteria in the oral cavity can easily lead to common oral diseases such as tooth decay and periodontal disease. There are more than 600 kinds of bacteria in the oral cavity, and the common ones are sputum-producing capnocytobacter, brevis staphylococcus aureus, streptococcus mutans, oral streptococcus, Escherichia coli, Pseudomonas aeruginosa and streptococcus thermophilus. Mouthwash can go deep into all parts of the mouth, reduce the bacteria and plaque that cause bad breath, and improve the health of the gums. [0003] Most of the mouthwash products with antibacterial function on the market have added chemical bactericides, such as dichlorophenoxychlorophene, etc., but they have stro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/64A61K8/34A61K8/37A61K8/73A61K8/88A61Q11/00A61Q17/00
CPCA61K8/345A61K8/375A61K8/64A61K8/73A61K8/738A61K8/88A61K2800/56A61Q11/00A61Q17/005
Inventor 张翠平
Owner 苏州承芃和医药科技有限公司
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